Amazon.com description: Product Description: This volume examines the genetics, molecular biology, and clinical features of diseases resulting from defects of mitochondrial DNA (mtDNA) and describes current strategies for diagnosing and treating mitochondrial diseases. Coverage includes chapters on diseases associated with spontaneous deletions and duplications, maternally inherited defects, inherited Mendelian defects, and quantitative defects of mtDNA. Close attention is given to the role of mtDNA mutation in brain and muscle aging and in Alzheimer's, Parkinson's, and other neurodegenerative diseases. The book also discusses the treatment of mitochondrial diseases with various vitamins and drugs, including thiamine, riboflavin, folates, vitamins C, E, and K, coenzyme Q0, succinic acid, corticosteroids, lazaroids, monoamine oxidase inhibitors, chloramphenicol, L-carnitine, and acetyl-L-carnitine.