Product Description: This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction...read more

Product Description: The concept of mitochondrial diseases originated in 1962 with the description by Luft and coworkers of a patient with nonthyroidal hypermetabolism due to loose coupling of oxidation and phosphorylation in muscle mitochondria. Over the following quarter of century, thanks to W...read more (view table of contents, read Amazon.com's description)

Product Description: This brand-new text provides you with an easy-to-use, comprehensive reference that features a clinical perspective balanced with relevant basic science. Inside, you'll find discussions of the latest research and how it has led to a greater understanding of the cause of disease, as well as burgeoning tests and the latest therapeutic agents available...read more

The United States Congress has designated the 1990's as the "Decade of the Brain" in recognition of the major importance of neurology and the other neurosciences in the health and well-being of Americans. It has been suggested that as many as 20% of all patients seeking medical treatment have neurologic problems, either as the presenting complaint or as an associated condition complicating the primary illness. Thus, it is fitting that Springer-Verlag should acknowledge the prominence of this medical specialty area by devoting an entire volume of the Oklahoma Notes series to neurology and clinical neuroscience. Of course, this text is an outline overview and does not attempt to provide ency­ clopedic coverage of neurology. (The student desiring a comprehensive review of the field may wish to seek in the library the 50+ volumes in the series Handbook of Clinical Neurology edited by Pierre J. Vinken and George W. Bruyn.) However, the information selected for inclusion in this volume of the Oklahoma Notes series remains true to the goal of the whole series-only materials vital in both the general clinical practice of medicine and to answer questions on the all-important United States Medical Licensing Examination have been incorporated in the text. (view table of contents)

Product Description: This volume examines the genetics, molecular biology, and clinical features of diseases resulting from defects of mitochondrial DNA (mtDNA) and describes current strategies for diagnosing and treating mitochondrial diseases. Coverage includes chapters on diseases associated with spontaneous deletions and duplications, maternally inherited defects, inherited Mendelian defects, and quantitative defects of mtDNA...read more

Product Description: This volume presents molecular and genetic studies that shed new light on the pathogenesis of these diseases. The contributors show how molecular and genetic analyses of mitochondria can explain the variable clinical features of mitochondrial encephalomyopathies and provide a basis for classifying these diseases...read more