Product Description: Nachdruck des Originals von 1921.

Product Description: Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome...read more

Product Description: Severe sepsis and septic shock are the most serious compli­ cations of bacterial infections. Both gram-positive and gram­ negative bacteria can trigger these extreme inflammatory re­ sponses and, by so doing, cause substantial morbidity and mortality...read more

Product Description: The international workshop on "Specificity and Function of Clonally Developing T Cells" was held at SchloG Rei sensburg (near UIm, West Germany) on March 17-20, 1985. The meeting brought together immunologists study ing clonal T-cell development in man and mouse in various in vitro systems at the cellular as well as molecular level...read more

Product Description: Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer's patches (PP), then to lymph and back to blood (GOWANS and KNIGHT 1964). Smaller numbers of lymphocytes migrate from blood to extranodal tissues such as pancreas and then through lymphatic vessels to LN (MACKAY et al...read more

On occasion, the innate immune system is referred to as the "primitive" immune system. Perhaps this has dissuaded immu­ nologists from analyzing it as energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is "of the first type", there is nothing crude, nothing unsophisti­ cated, and nothing "inferior" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due. Any immune system has two cardinal functions. It must destroy a broad range of pathogens, and it must spare the host. The adaptive immune system has applied a modular solution to these problems. Each cell of the adaptive immune system is prescreened to eliminate those that would produce untoward interactions with self; each cell is pre-programmed to recognize a foreign epitope that the host might one day encounter. Hence, the duties of each individual lymphocyte are quite circumscribed.

Product Description: Nachdruck des Originals von 1923.

Product Description: Dieses Buch beschreibt im Detail die gesamte Geschichte der frühen wie der modernen wissenschaftlichen Nautik und verdeutlicht, wie elementar schwierig die Bedingungen früher in der Seefahrt waren. Auch heute noch ein äußerst lesenwertes Buch, das dem Leser die Grundlagen der Nautik im Zeitalter vor der Satellitennavgation nahe bringt...read more

Product Description: Our current understanding of a/~ T cell receptor (TCR) ex­ pressing T cells advanced from function and specificity to the molecular organization ofthe TCR.We now know that the TCR a and ~ chains together express specificity for (antigenic) peptides presented by the "responder" M H C allele, thus explain­ ing the phenomenon of MHC restriction at a molecular level...read more