Product Description: The methodology of drug development has been the subject of extensive dis­ cussion by a relatively small group of individuals in industry and government who have been intimately concerned with the identification and study of new anticancer drugs...read more

Product Description: The decade of the 1990s will see an increasing emphasis on the modulation of chemotherapeutic drug selectivity and in the 'lock and key' approach to new targets to control malignant proliferation. The contents of this volume appropriately reflect these scientific undercurrents...read more

Concepts, Mechanisms, and New Targets for Chemotherapy describes new interconnections between rationally designed and empirically discovered compounds. One route that has not been travelled previously is that of protein kinase C inhibition. This pathway may be exploited to give potent inhibitors, such as the bryostatins, now in clinical trial. A summary is given of the current status of topoisomerase, focusing on recent clinical advances with camptothecin analogs based on connecting empiricism with concepts of drug selectivity. Modification of existing therapies based on the pursuit of leads arising from mechanistic studies is also being applied clinically on a wide scale. Greater understanding should follow from the studies of reversal of the multidrug resistant phenotype, on the use of hydroxyurea to reverse resistance mediated by extrachromosomal DNA, and on various aspects of the fluoropyrimidine pathways. Successful applications of chemotherapy to the treatment of specific diseases include the growing applications of systemic therapy using various skin malignancies. In prostate cancer, estramustine phosphate will likely play an expanding role. Taxanes are restructuring treatment regimens in breast cancer, and high-dose strategies are described with peripheral blood progenitor autografting in the treatment of ovarian and breast cancers.

Product Description: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients...read more

Product Description: Where do you begin to look for a recent, authoritative article on the diagnosis or management ofa particular malignancy? The few general onco­ logy textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often prelimi­ nary reports on a very limited number of patients...read more

Product Description: Experimental chemotherapy continues to be at the forefront of cancer thera peutics. Topics covered in the preceding volume on cancer chemotherapy in this series such as study of drugs by alkaline elution, the development of the antimetabolite tiazofurin, and the treatment of germ cell tumors have become informative references to current experimentalists and practitioners...read more

Product Description: As in CANCER CHEMOTHERAPY 1, this volume brings to the reader highlights in three different areas of cancer therapeutics: new concepts and models; drug classes; and clinical settings. Topics were chosen because of their timeliness or probable current impact in cancer treatment...read more

Product Description: For the Editors, the task of writing a Preface is most satisfying. It represents the completion of the book and a moment of reflection on whether the whole is more than the sum of all the parts. And also, one must reflect on how this book is likely to be utilized in this era of rapid communications...read more

A balanced, broad-based, up-to-date presentation of the occurrence, availability, and usage of Earth's mineral resources. Completely updated and expanded, this edition includes greater emphasis on the environment. *Does not require extensive scientific background. *Coverage of all important types of resources (energy, metallic, nonmetallic, water, soil). *Discusses the environmental impact of resource exploitation and usage. *Provides historical perspectives in an overview chapter as well as in the discussions of all resources - so students can understand not only what is used, but how usage has changed over time. *New - "Focal points" - chapter objectives listed at the beginning of each chapter to help guide students as they read. *New - special interest boxes added on acid rain, the dust bowl, synthetic diamonds, etc.

Product Description: Assembly of this large body of knowledge into one book provides a valuable reference source for lab investigators, clinical oncologists, and general practitioners, medical or surgical. The authors assess the role of cancer therapy in cardiotoxicity, beginning with a discussion of myocardial disease induced by chemotherapy, radiation, and biological agents...read more

Product Description: Neoplastic disease confined to the liver is an important worldwide problem. In the industrialized nations, metastatic disease of the most common cancers involves the liver in upwards of 50% of cases. Primary hepatic tumors are virtually epidemic in most third world countries and certainly constitute one of the ten most common causes of cancer deaths on a worldwide scale...read more

Product Description: Where do you begin to look for a recent, authoritative article on the diagnosis or management ofa particular malignancy? The few general onco­ logy textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often prelimi­ nary reports on a very limited number of patients...read more