Product Description: That chemicals (although not always called by this name) affect the brain and its functions, such as behavior, has been known for thousands of years. It is therefore surprising that the concept that chemical mechanisms are at least partially responsible for the complex functions of the brain is so recent...read more

Product Description: When the projected volumes of the Handbook are completed, most of our current knowledge of the biochemistry of nervous systems will have been touched upon. A number of the chapters will have dealt with the correlations of the biochemical findings with morphological and physio­ logical parameters as well...read more

Product Description: It has been recognized for more than a thousand years that the function of the brain, like the function of the other organs of the body, is determined by its physical, chemical, and biological properties. Evidence that even its highest functions could be explained by these properties was gathered only in recent years, however; these findings, which clearly have to be confirmed by a great deal of further experimental evidence, indicate that most, if not all, of the functions of the brain are based on its bio­ chemical and biophysical mechanisms...read more

Product Description: Life, either as we think of it in the abstract in its highest sense, or life, as we think of it in terms of a compact living organism, is obviously the result of complex interaction of all of the components of the organism. One could therefore question the advisability of separating out the nervous system for a special detailed study in our age of overspecialization...read more

Product Description: After the completion of the first edition of this series, this editor thought that a new edition would not be warranted in less than IS, perhaps 20, years, but it seems that we live in a time in which rapid changes are the norm and findings in a field such as neurochemistry develop exponentially...read more

Product Description: In neurosciences one may say, '"All roads lead to Rome. " It seems as though wherever one starts, the course of investigation leads to the same major ques­ tions about nervous system function and dysfunction. In thinking about what to write in this preface, it occurred to me that it might be best to deal with that with which I am most familiar and to trace to some extent my own '"road to Rome...read more

Product Description: A major advance in the biological sciences in the past decade has been the biochemical identification of cell membrane receptors. The existence of re­ ceptor substances on the surface of cells that recognize and bind to extracellular molecules was proposed at the beginning of the century by the pharmacologist and immunologist Paul Ehrlich and the physiologist J...read more

Product Description: This volume is concerned with the enzymes of the nervous system. Cerebral enzymes form the basis of the functional brain. They are needed for the control of the energetics of the nervous system, whether it be their release or their direction; for the elaboration of transmitters and for their destruction; for the synthesis, transport, and breakdown of all metabolites of the nervous system...read more

Product Description: The content of Volume 8 of the Handbook of Neurochemistry is a perfect example and sample of what occupies neurochemists in the late 1980s. What occupies them are questions, concepts, and technology that either did not start with the nervous system, or rapidly moved out of its exclusivity (see, for in stance, chapters on neurotensin, beta-lipotropin, behavioral and neurochemical effects of ACTH, cholecystokinin, etc...read more

Product Description: Few can deny the paramount importance of the neurosciences, undoubtedly one of the most challenging fields in contemporary science. Recent years have witnessed the awakening of interest in brain research by many dis­ tinguished investigators from other branches of science, which has made possible the multidisciplinary approach needed for the complex problems of this field...read more

Product Description: Neurochemistry, having the objective of elucidating biochemical processes subserving nervous activity, emerged as an application of chemistry to the of neurobiological problems as a post-World War II phenomenon. investigation However, only in the last 40 years has the chemical community recognized neurochemistry as a distinct, if hybrid, discipline...read more

Product Description: This volume is concerned with metabolic reactions occurring in the nervous system. Some time ago, it was thought that since most of the intermediary metabolism that can be observed in the brain is not specific to this organ, there is little justification in studying neural metabolism as such...read more

Product Description: Anyone who has any contact with mental patients, old or young, or their families, or just visits a mental hospital or school for the retarded, is aware of the tremendous suffering caused by malfunctioning of the brain. The func­ tion of no other organ is so crucial for our everyday life, our proper func­ tioning, indeed our happiness, and no other illness causes as much anguish to patients or their families as mental illness...read more

Product Description: The Second Edition of the Handbook of Neurochemistry, which was published about 24 years ago, consisted of 10 volumes. The present, Third Edition, The Handbook of Neurochemistry and Molecular Biology, is over twice as large; indicating a great expansion of neuroscience in the past two decades...read more

Product Description: This volume of the Handbook of Neurochemistry and Molecular Neurobiology focuses on neurochemical aspects of schizophrenia. Chapters cover the full range of schizophrenia symptoms and anatomical pathologies from neurochemical and molecular biology perspectives...read more

Product Description: The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline...read more

Product Description: Over the last decade, the considerable progress made in biochemistry, molecular biology, genetics and neuropharmacology has revealed some ofthe intimate mechanisms ofthe neurodegenerative disorders. There is increasing evidence linking genetic defects affecting mitochondria to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and some other neurological disorders...read more

Product Description: Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved...read more (view table of contents, read Amazon.com's description)