Product Description: Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes...read more

Product Description: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research...read more

Product Description: Molecular Pharmacology of Cell Regulation Series Editor: Miles D. Houslay This important series provides topical, in-depth and authoritative reviews on all aspects of the molecular mechanisms of cell regulatory processes. It attempts to unravel the molecular structures, properties and functions of systems which provide putative targets for the next generation of drugs...read more (view table of contents, read Amazon.com's description)

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Product Description: This is the first book to chart the progress of our understanding of signal transduction in multicellular organisms. The articles, written by an international group of active researchers, relate structure to function and incorporate recent discoveries of changes in signalling molecules in pathological and transformed states...read more