Amazon.com description: Product Description: This book reviews our current level of understanding of the role of genetic instability in human tumorigenesis. In this most rapidly moving field, discoveries in recent years have elucidated a number of important gene products which control cellular responses to DNA damaging agents, e.g., DNA repair and cell cycle perturbations. Mutations in these genes appear to be important contributors to the development of a significant percentage of human tumors. The reviews cover the gamut from scientific insights into genetic instability learned from simple model systems, e.g., yeast, to the genes which control these processes in human cells and contribute to human tumor development. Such information is being used to develop approaches to reduce cancer development and to provide more specific targets to improve cancer therapies.