Grizzled homicide detective Bernie “Burnout” Farrell heads the hunt for a serial killer who is murdering call girls around Times Square. Hoping to set up a stakeout, Farrell recruits tall, blonde, ambitious rookie cop Gladyss Chronou for the investigation. But Gladyss believes her mystical yoga practice can give her an intuitive edge in solving the crimes and sees mythological patterns in the suspects and events they’re investigating. Bernie thinks she’s nuts, but then, he's a little too grounded. In fact, he's on a steady downward spiral: his wife is divorcing him, his longtime partner just died of AIDS, and he's developed a nagging cough since working down at Ground Zero.

Gladyss of the Hunt oscillates between chilly street realism and new age mysticism. As their investigation takes Bernie and Gladyss from arty society gatherings to shabby hotels and SROs, the narrative offers a suspenseful, often wittily satirical account of a city that is flashy and glamorous one moment, dark and violent the next.