This proposal for a platform of education reform needed to prepare students for a 21st-century workplace and society draws on information and ideas from two current areas in neuroscience: brain research (physiology and applications to learning) and systems thinking (mental models). Analyzing the history of education methodology over the past two centuries, this book shows how the 19th-century factory model prevalent in schools today fails to produce the kinds of flexible thinkers and problem solvers needed in the 21st century. A comprehensive tour of the brain and details of the most recent neuroscience findings inform a plan to arm today’s students with an education lacking in traditional classrooms. Also included are dozens of ideas for brain-compatible activities that can be adapted for use in the classroom.