Preface

List of abbrevations

Part 1. New immunoregulatory bone marrow peptides, myelopeptides

Discovery of bone marrow factor(s)

Cell cooperation at the level of mature antibody producers

Stimulator of antibody producers, SAP

SAP structural heterogeneity

Myelopeptides: A group of bone marrow bioregulatory mediators

Peptide nature of bone marrow mediators

Biological activities of myelopeptides

Immunostimulating effects of myelopeptides

Myelopeptides and immunocorrection

Differentiating activity of myelopeptides

Neurotropic effects of myelopeptides

Myelopeptides and human immune reactions

Influence of myelopeptides on the functional activity of human peripheral blood cells from healthy donors and immunodeficient patients

Influence of myelopeptides on bone marrow and peripheral blood cells obtained from healthy donors and patients with some hemopoietic disorders

Myelopid: A medicinal preparation developed on the basis of native myelopeptide mixture

Part 2. Individual myelopeptides: Structure, function, mechanism of action

Isolation, identification and synthesis of myelopeptides

MP-1 is a myelopeptide with immunocorrective activity

MP-1 stimulates antibody formation at the peak of immune response

MP-1 ability of immunocorrection

MP-1 specific binding with target cell

MP-2 is a myelopeptide with antitumor effect

MP-2 recovers T lymphocyte functional activity inhibited by tumor cells

Antitumor action of MP-2 in vivo

MP-2 antitumor effect in vivo is mediated by T system of immunity

Conformational study of MP-1 and MP-2

MP-3 is a myelopeptide stimulating macrophage phagocytosis

MP-4 is a cell differentiation factor

Myelopeptides: A new class of endogenous bioregulatory peptides

Conclusion

References