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Tables of Contents for Tissue Restoration Through Regenerative Biology and Medicine
Chapter/Section Title
Page #
Page Count
1 Introduction
1
46
1.1 The Biology of Regeneration
3
1
1.2 Regeneration of Ectodermal Derivatives
4
17
1.2.1 Uninjured Epidermis
4
1
1.2.2 Injured Epidermis
5
2
1.2.3 Hair
7
1
1.2.4 Nervous System
8
13
1.2.4.1 Axon Regeneration in Mammals
9
4
1.2.4.2 Regeneration of Amphibian and Avian Optic Nerves
13
1
1.2.4.3 Axon Regeneration in the Amphibian Spinal Cord
14
2
1.2.4.4 Neurogenesis in the Regenerating Amphibian Tail
16
2
1.2.4.5 Neurogenesis in the Adult Mammalian Brain
18
2
1.2.4.6 Injury-Induced Neurogenesis
20
1
1.3 Regeneration of Endodermal Derivatives
21
7
1.3.1 Liver
21
6
1.3.1.1 Proliferation Capacity and Kinetics
22
1
1.3.1.2 Gene Activity of Proliferation
23
1
1.3.1.3 Initiation of Liver Regeneration
24
2
1.3.1.4 Stopping Proliferation
26
1
1.3.1.5 Remodeling
26
1
1.3.1.6 Liver Regeneration via Stem Cells
27
1
1.3.2 Pancreas
27
1
1.4 Regeneration of Mesodermal Derivatives
28
9
1.4.1 Skeletal Muscle
29
4
1.4.1.1 Origin of Regenerated Myofibers
29
1
1.4.1.2 Cellular and Molecular Events of Muscle Regeneration
30
2
1.4.1.3 Regulation of Muscle Regeneration by Growth Factors
32
1
1.4.2 Bone
33
3
1.4.2.1 Bone Regenerates via Mesenchymal Stem Cells
33
1
1.4.2.2 Regulation of Bone Regeneration by Growth Factors
34
2
1.4.3 Blood and Lymphoid Cells
36
1
1.5 Developmental Potential of Adult Stem Cells
37
10
1.5.1 Neural Stem Cells
38
1
1.5.2 Hepatic Oval Cells
39
1
1.5.3 Satellite Cells
40
1
1.5.4 Bone Marrow Cells
40
4
1.5.4.1 Unfractionated Bone Marrow
40
1
1.5.4.2 Hematopoietic Stem Cells
41
1
1.5.4.3 Mesenchymal Stem Cells
42
1
1.5.4.4 Multipotential Adult Progenitor Cells of Bone Marrow
43
1
1.5.5 What Is the Basis of Adult Stem Cell Potency?
44
3
2 Regenerative Medicine
47
28
2.1 Cell Transplants
47
10
2.1.1 Central Nervous System
49
2
2.1.1.1 Demyelinating Disorders
49
1
2.1.1.2 Spinal Cord Injury
50
1
2.1.1.3 Parkinson's Disease
50
1
2.1.2 Myocardial Infarction
51
2
2.1.3 Osteogenesis Imperfecta
53
1
2.1.4 Diabetes
53
1
2.1.5 Skin Injuries
54
1
2.1.6 Cartilage and Bone Injuries
55
1
2.1.7 Research Issues in Cell Transplantation
55
2
2.1.7.1 Cell Sources
55
1
2.1.7.2 Biomaterials for Bioartificial Tissues
56
1
2.2 Chemical Induction of Regeneration in Vivo
57
18
2.2.1 Evidence for Latent Regenerative Capacity in Mammals
57
3
2.2.1.1 New Cardiomyocytes Appear After Myocardial Infarction
57
2
2.2.1.2 Stem Cells Reside in Non-regenerating Tissues
59
1
2.2.1.3 Induction of Dedifferentiation of Mouse Myotubes
59
1
2.2.2 Interventions to Promote Regeneration in Vivo
60
7
2.2.2.1 Peripheral Nerve
60
1
2.2.2.2 Spinal Cord Injury
61
4
2.2.2.3 Parkinson's Disease
65
1
2.2.2.4 Bone and Cartilage
65
1
2.2.2.5 Skin Wounds
66
1
2.2.2.6 Use of Pig Small Intestine and Urinary Bladder Submucosa as a Regeneration Template
67
1
2.2.3 Strategies to Define the Molecular Requirements for Chemical Induction of Regeneration
67
8
2.2.3.1 Comparison of Mutant Vs Wild-Type Tissues
68
1
2.2.3.2 Comparison of Regeneration-Competent Vs Regeneration-Deficient Stages of the Life Cycle
69
4
2.2.3.3 Regeneration-Competent Vs Regeneration-Deficient Species
73
2
3 Perspectives
75
2
References
77
26
Subject Index
103