Preface

Acknowledgements

List of Contributors

Abbreviations

Introduction

Organophosphates: History, Chemistry, Pharmacology

Timothy C. Marrs

Socio-Economics, Health Issues and Pesticides

Lakshman Karalliedde

Tim Meredith

Factors Influencing Organophosphate Toxicity in Humans

Philippa Edwards

Organophosphorus Chemical Warfare Agents

Timothy C. Marrs

Robert L. Maynard

The Acute Cholinergic Syndrome

Lakshman Karalliedde

John Henry

The Intermediate Syndrome

Jan L. de Bleecker

Organophosphorous-Induced Delayed Polyneuropathy

Nimal Senanayake

The Effects of Organophosphates on Neuropsychiatric and Psychological Functioning

Malcolm Lader

Effects of Organophosphates on the Neuromuscular Junction and Muscle

Stanley Feldman

Organophosphates and the Cardiovascular System

A.M. Saadeh

Gulf War Syndrome, Idiopathic Environmental Intolerance and Organophosphate Compounds: Diseases in Search of Causal Hypothesis

Jeffrey Brent

Laura Klein

Management of Organophosphorus Compound Poisoning

Lakshman Karalliedde

Ladislaus Szinicz

Carcinogenicity and Mutagenicity of Organophosphates

Michael D. Waters

H. Frank Stack

Marcus A. Jackson

Organophosphorus Agents and the Environment

Elwood F. Hill

Biochemical and Toxicological Investigations Related to OP Compounds

R. Swaminathan

Brian Widdop

Monitoring Occupational Exposures to Organophosphorus Compounds

Angelo Moretto

Marcello Lotti

The Global Picture of Organophosphate Insecticide Poisoning

Lakshman Karalliedde

Michael Eddleston

Virginia Murray

Index