Foreword

Series Foreword

1. Methodology

In Vitro Carcinogenesis of Human Bronchial Epithelial Cells

CHRISTOPHER H. KENNEDY

JOHN F. LECHNER

Peptide Growth Factors in Fibroproliferative Lung Disease: In Vivo Models and In Vitro Correlates

ARNOLD R. BRODY

Relationship Between DNA and Chromosome Damage and Mesothelial Cell Transformations: Significance for In Vitro Assessment of Carcinogenic Potential

MARIE-CLAUDE JAURAND

SOPHIE ELLOUK-ACHARD

MICHEL YEGLES

HANG YING DONG

VALERIE LEVRESSE

ANNIE RENIER

p53 Tumor Suppressor Gene: Implications for Respiratory Carcinogenesis

MARC S. GREENBLATT

WILLIAM P. BENNETT

CURTIS C. HARRIS

The Lung Slice: An In Vitro Model for the Study of Lung Injury

PAUL SHAPIRO

P. MARLENE ABSHER

WILLIAM S. STIREWALT

KEVIN O. LESLIE

JOHN N. EVANS

In Vitro Ozone Exposure Induces Increased Expression of mRNAs Coding for IL-6 and a chemokines, but Not B Chemokines, in Human Airway Epithelial Cells

ROBERT B. DEVLIN

KAREN P. McKINNON

WILLIAM REED

JACQUELINE D. CARTER

JACQUELINE L. QUAY

Statistical Methods for Comparing In Vitro and In Vivo Investigations

BERTHOLD SCHNEIDER

Possibilities to Check In Vitro/In Vivo Correlations When Validating In Vitro Methods in Toxicology

HORST SPIELMANN

MANFRED LIEBSCH

BEATE DORING

FERDINAND MOLDENHAUER

HERMANN-GEORG HOLZHUTTER

WOLFGANG W. PAPE

ODILE DE SILVA

Do In Vitro Models Improve Our Understanding of In Vivo Phenomena?

HILLEL S. KOREN

SUSANNE BECKER

MARYJANE K. SELGRADE

ROBERT B. DEVLIN

TERRY L. NOAH

Central Issues in Inhalation Toxicology

JOSEPH D. BRAIN

2. Research Findings and Interpretations

In Vivo and In Vitro toxicity of Manmade Vitreous Fibers

T.W. HESTERBERG

G.A. HART

W.C. MIILLER

P. THEVENAZ

Asbestos and Mesothelioma: Tumor Cell Characteristics and Mechanisms in Fiber Carcinogenesis

KAIJA LANNAINMAA

KATARINA PELIN

VUOKKO KINNULA

Regulation of Mesothelial Cell Proliferation In Vitro and In Vivo

AGNES B. KANE

JANICE L. MACDONALD

CHARLES A. VASLET

Molecular Markers of Cell Proliferation and Injury: Correlations Between In Vitro Observations and Rodent Inhalation Studies Using Crocidolite Chrysotile Asbestos

BROOKE T. MOSSMAN

PING TAISHI

TIM QUINLAN

CINDY TIMBLIN

KELLY BERUBE

JOANNE MARSH

L. ALBERT JIMENEZ

PAMELA VACEK

YVONNE M.W. JANSSEN

Application of Surface Science and Microlithography Methods to Make Well-defined Fibers for Biological Evaluation

B. KASEMO

J. GOLD

The Role of Nitric Oxide Radicals in Asbestos-induced Pulmonary Injury

ELLIOTT KAGAN

Interactions Between Oxidant Gases and Airway Epithelium: In Vitro-In Vivo Correlations

DAVID T. WRIGHT

BERNARD M. FISCHER

CHENG MING LI

KEITH A. YAGALOFF

KENNETH B. ADLER

Injury to Pulmonary Surfactant by Reactive Oxygen and Nitrogen Species

SADIS MATALON

SHA ZHU

GYORGY PATAKI

IMAD Y. HADDAD

In Vitro Assessment of Ozone-induced Injury to Alveolar and Tracheobronchial Epithelium

C.G. PLOPPER

J.M. CHEEK

R. WU

S. REDDY

Y. ZHAO

X. DUAN

A.R. BUCKPITT

A Combined In Vitro-In Vivo Approach for the Study of Human Respiratory Tract Carcinogenesis

A.J.P. KLEIN-SZANTO

C.C. HARRIS

S. MOMIKI

T. IIZASA

M. BABA

Mammalian Organism-Cell Cultures-Enzymes: A Comparison of In Vivo and In Vitro Systems

DR. JURGEN JACOB

In Virto and In Vivo Approaches for Extrapolation of 1, 3-Butadiene Metabolism in Laboratory Animals to Humans

JAMES A. BOND

MATTHEW W. HIMMELSTEIN

MAX J. TURNER

MICHELE A. MEDINSKY

Human Lung Carcinogenesis: Approaches to Identify Carcinogenic Risk

AAGE HAUGEN

DAVID RYBERG

Aldehyde Toxicity and Thiol Redox State in Cell Cultures from Human Aerodigestive Tract

ROLAND C. GRAFSTROM

MARGARETA I. JERNELOV

JEANNETTE M. DYPBUKT

KRISTINA SUNDQVIST

LUIGI ATZORI

XI ZHENG

Polyamine Regulatory Mechanisms in Hypertensive Pulmonary Vascular Disease

MARK N. GILLESPIE

JACK W. OLSON

Nonmutagenic Mechanisms of Nickel Carcinogenesis: Inactivation of Critical Genes by Nickel-induced DNA Methylation and Chromatin Condensation

MAX COSTA

Putative Role for Cadmium in the Pathogenesis of Emphysema

RACHEL C. CHAMBERS

GEOFFREY J. LAURENT

Cellular Effects of Cadmium: Interference with DNA Repair and Gene Regulation

DETMAR BEYERSMANN

ANDREA HARTWIG

Biodosimetric Approach for Estimating Alpha Particle Does to Respiratory Tract Epithelial Cells

N.F. JOHNSON

A.W. HICKMAN

T.R. CARPENTER

G.J. NEWTON

3. Relevance for Risk Assessment

The Use of Short-term In Vivo Bioassays: Making Links with Epidemiology and Chronic Animal Studies

JOSEPH D. BRAIN

The Contribution of In Vitro Pharmacodynamic Studies of Volatile Chemicals to Risk Assessment

P.M. HEXT

I.F.H. PURCHASE

Assessments of In Vitro Effects of Dusts on Pulmonary Cells Using Macrophage-Epithelial Cells in Co-culture

D.B. WARHEIT

S. SNAJDR

M.A. HARTSKY

I.S. YUEN

Linkages Between In Vitro Findings and Quantitative Risk Assessment of Mineral Fibers Based on Animal Studies

J. BIGNON

D. BERNSTEIN

C. PAIRON

P. BROCHARD

Integration of In Vitro and In Vivo Findings for Quantitative Risk Assessments for Airborne Particulate Material: A Synthesis

ROGER O. McCLELLAN

Index