Preface

1. Developing Pharmaceutical Protein Formulations: Assumptions and Analytical Tools

Zahra Shahrokh

2. The Pharmaceutical Development of Insulin: Historical Perspectives and Future Directions

Henry R. Costantino

Stanley Liauw

Samir Mitragotri

Robert Langer

Alexander M. Klibanov

Victoria Sluzky

3. Stability of the Dipeptide Aspartame in Solids and Solutions

Leonard N. Bell

4. Mechanisms of Methionine Oxidation in Peptides

Christian Schoneich

Fang Zhao

Jian Yang

Brian L. Miller

5. A Discussion of Limitations on the Use of Polymers for Stabilization of Proteins During the Freezing Portion of Lyophilization

David M. Barbieri

Martin C. Heller

Theodore W. Randolph

John F. Carpenter

6. Phase Separation and Crystallization of Components in Frozen Solutions: Effect of Molecular Compatibility Between Solutes

Ken-ichi Izutsu

Sumie Yoshioka

Shigeo Kojima

7. In Situ Formation of Polymer Matrices for Localized Drug Delivery

Jennifer L. West

8. Transdermal Delivery of Macromolecules: Recent Advances by Modification of Skin's Barrier Properties

Mark R. Prausnitz

9. Amino Acid Derived Polymers for Use in Controlled Delivery Systems of Peptides

S. Brocchini

D.M. Schachter

J. Kohn

10. Analysis of the Solution Behavior of Protein Pharmaceuticals by Laser Light Scattering Photometry

Gay-May Wu

David Hummel

Alan Herman

11. Applications of Ultraviolet Absorption Spectroscopy to the Analysis of Biopharmaceuticals

Henryk Mach

Gautam Sanyal

David B. Volkin

C. Russell Middaugh

12. Surfactant-Stabilized Protein Formulations: A Review of Protein-Surfactant Interactions and Novel Analytical Methodologies

LaToya S. Jones

Narendra B. Bam

Theodore W. Randolph

Author Index

Affiliation Index

Subject Index