Series Introduction

Preface

Contributors

Introduction: The Graft-Versus-Leukemia Effect

Paul M. Sondel

Part I: Biological Basis of the GVL Effect

The Immune Response to Alloantigens

Graham M. Lord

Robert I. Lechler

Experimental Animal Models in the Study of GVL Reactions

Robert L. Truitt

Robert Korngold

Bryon D. Johnson

Robert Townsend

Bruce R. Blazar

Effector Cells and Mechanisms of the GVL Effect

Yin-Zheng Jiang

Minor Histocompatibility Antigens in GVL

Tuna Mutis

Els Goulmy

Tissue-Specific Antigens in GVL

Jeffrey J. Molldrem

Oncoproteins as Tumor-Specific Antigens

Carlo Gambacorti-Passerini

Part II: The GVL Effect in Clinical Practice

GVL Effects in Human Marrow Stem-Cell Transplants

John Barrett

The GVL Effect in Donor Lymphocyte Transfusion

Frits van Rhee

Hans-Jochem Kolb

The Graft-Versus-Myeloma Effect

Jayesh Mehta

The Graft-Versus-Tumor Effect

Richard W. Childs

John Barrett

Adoptive Allogeneic Cell-Mediated Immunotherapy and Nonmyeloablative Stem-Cell Transplantation

Shimon Slavin

Shoshana Morecki

Elizabeth Naparstek

Arnon Nagler

Gabor Varadi

Rami Ben-Yosef

Reuven Or

Clinical and Basic Science Studies of Human Umbilical Cord Blood: Implications for the GVL Effect Following Cord Blood Transplantation

Jay Gaddy

Pierluigi Porcu

Hal E. Broxmeyer

Part III: Modulation and Application of GVL Effects

Separating GVHD and GVL Reactions

Dimitrios Mavroudis

John Barrett

T-Cell Subsets and Separation of GVL from GVHD

Sergio A. Giralt

Richard E. Champlin

Molecular Immunological Modulation of Target Cells to Enhance the GVL Effect

Joachim L. Schultze

John G. Gribben

Genetic Modulation of Effector Cells to Enhance GVL Effects

Helen E. Heslop

Koichi Moriwaki

Leukemia-Reactive T Cells in Adoptive Immunotherapy for Relapsed Leukemia After Allogeneic Transplantation

J. H. Frederick Falkenburg

Roelof Willemze

The BCR-ABL Oncoprotein and Immunological Targeting: Vaccination for Tumor Prevention and Therapy

George J. A. ten Bosch

Onno C. Leeksma

Cornelius J. M. Melief

Index