List of Contributors

Preface by the editors

Lipoproteins and Oxidation: Clinical Aspects of Lipoprotein Metabolism and Oxidation

H. Robert Superko

Pathogenesis of Artherosclerosis

Robert Gallo

Valentin Fuster

The Antioxidant Hypothesis

Marc Forgione

Joseph Loscalzo

Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease

Jun-ichi Abe

Bradford C. Berk

Pharmaceutical Compounds with Antioxidant Activity

Aalt Bast

Guido R.M.M. Haenen

Nutrition and Antioxidants

Paolo Rubba

Mario Mancini

Antioxidants and Vascular Disease: Animal Studies

John F. Keaney, Jr.

Antioxidants and Endothelial Function-Human Studies

Christian Bingelli

Isabella Sudano

Georg Noll

Thomas F. Luscher

Antioxidant Vitamins and Cardiovascular Disease: Evidence from Observational Epidemiologic Studies and Randomized Trials

William G. Christen

Charles H. Hennekens

A Rationale for Antioxidant Use in Cardiovascular Disease

R. Preston Mason

Antioxidants and Restenosis-Animal Studies

Antoine Lafont

Francois Vinchon

Faouzi Addad

Eric Durand

Antioxidants and Restenosis-Human Studies

Jean-Claude Tardif

Jean Gregoire

Martial G. Bourassa

Role of Oxidative Stress, Cytokines and Apoptosis in Myocardial Dysfunction

Douglas B. Sawyer

Wilson S. Colucci

Oxidative Stress and Use of Antioxidants in Patients with Congestive Heart Failure

Michel White

Jean-Claude Tardif

Martial G. Bourassa

Use of Antioxidants in Cardiovascular Medicine

Jawahar L. Mehta

Dayuan Li

Jason Mehta

Appendix

Update on Recently Completed Clinical Trials on Antioxidants and Cardiovascular Diseases

Jean-Claude Tardif

Martial G. Bourassa

Index