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Tables of Contents for Surgical Pathology of the Gi Tract, Liver, Biliary Tract, and Pancreas
Chapter/Section Title
Page #
Page Count
PART ONE Gastrointestinal Tract
SECTION I GENERAL PATHOLOGY OF THE GI TRACT
3
118
Gastrointestinal Tract Endoscopic and Tissue Processing Techniques
3
16
Brian C. Jacobson
James M. Crawford
Francis A. Farraye
Introduction
3
1
Bowel Preparation
3
1
Methods for Obtaining Tissue Specimens
4
3
Pathologic Features of a Healing Biopsy Site
7
2
Processing of Tissue Specimens for Histologic Analysis
9
1
Methods for Obtaining Cytology Specimens
10
3
Screening and Surveillance Guidelines in Gastroenterology
13
6
Diagnostic Cytology of the GI Tract
19
12
Helen H. Wang
Introduction
19
1
Normal Morphology
20
1
Infections
20
3
Inflammatory/Reactive/Metaplastic Changes
23
1
Neoplastic Lesions
24
7
Infectious Diseases of the GI Tract
31
26
Laura W. Lamps
Introduction
31
1
Viral Infections of the Gastrointestinal Tract
31
3
Bacterial Infections of the Gastrointestinal Tract
34
11
Fungal Infections of the Gastrointestinal Tract
45
2
Parasitic Infections of the Gastrointestinal Tract
47
5
Helminthic Infections of the Gastrointestinal Tract
52
5
Immunodeficiency Disorders of the GI Tract
57
16
Kay Washington
Primary Disorders of Immunodeficiency
57
9
Graft-Versus-Host Disease
66
2
Neutropenic Enterocolitis
68
1
The GI Tract in HIV Infection
69
4
Systemic Illnesses Involving the GI Tract
73
32
David N. B. Lewin
Introduction
73
1
Cardiovascular Disorders
73
4
Dermatologic Disorders
77
2
Endocrine Disorders
79
1
Hematologic Disorders
80
2
Metabolic Disorders
82
10
Pulmonary Disorders
92
1
Reproductive Disorders
92
1
Rheumatologic Disorders
93
2
Urologic Disorders
95
1
Miscellaneous Disorders
96
9
Neuromuscular Disorders of the GI Tract
105
16
Dhanpat Jain
Introduction
105
1
Neural Network of the Bowel
105
2
Esophagus
107
2
Stomach
109
1
Small and Large Intestine
110
11
SECTION II INFLAMMATORY DISORDERS OF THE GI TRACT
121
136
Inflammatory Disorders of the Esophagus
121
22
Mary P. Bronner
Reflux Esophagitis (Gastroesophageal Reflux Disease)
121
3
Reactive Hyperplasia and Dysplasia
124
1
Infectious Esophagitis
125
2
Pill- and Drug-Induced Esophagitis
127
1
Corrosive or Caustic Esophageal Injuries
127
1
Chemoradiation-Induced Esophagitis
128
1
Barrett's Esophagus
128
10
Eosinophilic Esophagitis
138
1
Esophageal Involvement in Collagen Vascular Disorders
139
1
Esophageal Manifestations of Dermatologic Diseases
139
1
Graft-Versus-Host Disease
139
1
Achalasia
139
1
Esophageal Involvement in Crohn's Disease
139
1
Esophageal Amyloidosis
139
1
Mallory-Weiss Tears and Other Traumatic Esophageal Diseases
139
4
Inflammatory Disorders of the Stomach
143
34
Robert M. Genta
Introduction
143
1
Classification and Grading of Gastritis: The Updated Sydney System
144
1
Histopathologic Features of Gastritis
145
7
Helicobacter pylori Gastritis
152
4
Autoimmune Gastritis
156
2
Lymphocytic Gastritis
158
1
Granulomatous Gastritis
159
2
Chemical (or Reactive) Gastropathy
161
1
Hemorrhagic Gastritis and Vascular Gastropathies
162
3
Special Problems in the Diagnosis of Gastric Biopsies
165
4
Diagnosis of Gastritis: Approach to Pathologic Evaluation of Gastric Biopsy Specimens
169
1
Using the Updated Sydney System
169
8
Inflammatory Disorders of the Small Intestine
177
36
Marie E. Robert
Congenital Anomalies Associated With Inflammation
177
2
Ischemic Disorders of the Small Intestine
179
2
Disorders of Malabsorption
181
6
Autoimmune Enteropathy
187
1
Tropical Sprue
188
1
Bacterial Overgrowth Syndrome (Blind Loop Syndrome, Stasis Syndrome)
189
1
Microvillous Inclusion Disease
189
1
Abetalipoproteinemia
190
1
Eosinophilic Gastroenteritis
191
1
Nutritional Deficiencies
192
1
Intestinal Lymphangiectasia
193
2
Waldenstrom's Macroglobulinemia
195
1
Inflammatory Bowel Disease
195
6
Radiation- and Drug-Induced Enteritis
201
2
Graft-Versus-Host Disease
203
1
Nonsteroidal Anti-inflammatory Drug-Induced Enteropathy
203
2
Ileal-Anal Pouch Inflammation (Pouchitis)
205
8
Inflammatory Diseases of the Large Intestine
213
34
Joel K. Greenson
Robert D. Odze
Introduction
213
1
Ulcerative Colitis
214
5
Crohn's Colitis
219
4
Chronic Inflammatory Bowel Disease, Type Unknown (Indeterminate Colitis)
223
2
Differential Diagnostic Considerations
225
1
Dysplasia in Inflammatory Bowel Disease
226
4
Other Colitides
230
10
Preparation Artifacts
240
1
Solitary Rectal Ulcer/Mucosal Prolapse Syndrome
241
1
Behcet's Syndrome
242
5
Inflammatory Disorders of the Appendix
247
10
Elizabeth Montgomery
Michael Torbenson
Normal Histology
247
1
Fibrous Obliteration of the Appendiceal Lumen (Neuroma, Neural Hyperplasia)
247
1
Anatomic Abnormalities of the Appendix
247
1
General Pathologic Features of Acute and Chronic Appendicitis
248
1
Periappendicitis
249
1
Infectious Causes of Acute Appendicitis
249
2
Chronic Inflammatory Diseases of the Appendix
251
1
Noninflammatory Abnormalities of the Appendix
252
5
SECTION III POLYPS OF THE GI TRACT
257
124
Polyps of the Esophagus
257
10
Audrey Lazenby
Introduction
257
1
Benign Epithelial Polyps
257
2
Malignant Epithelial Polyps
259
1
Benign Mesenchymal Polyps
260
3
Malignant Mesenchymal Tumors
263
4
Polyps of the Stomach
267
28
Jerrold R. Turner
Robert D. Odze
Introduction
267
1
Hyperplastic Polyps
267
5
Menetrier's Disease
272
2
Inflammatory Polyps
274
3
Hamartomatous Polyps
277
4
Embryonic Rests and Heterotopia
281
2
Epithelial Polyps
283
3
Nonepithelial Polyps
286
2
Lymphoid Polyps
288
2
Miscellaneous Polyps and Polyp-like Lesions
290
5
Polyps of the Small Intestine
295
32
Rhonda K. Yantiss
Donald A. Antonioli
Introduction
295
1
Hyperplasia and Heterotopia
295
6
Inflammatory Lesions
301
1
Hamartomas
301
3
Benign Epithelial Neoplasms
304
2
Malignant Epithelial Tumors
306
3
Polyposis Syndromes
309
1
Endocrine Tumors
310
7
Mesenchymal Tumors
317
1
Lymphoid Lesions
318
2
Summary
320
7
Polyps of the Large Intestine
327
54
Susan C. Abraham
Lawrence J. Burgart
Robert D. Odze
Introduction
327
1
Epithelial Polyps
327
32
Lymphoid Polyps
359
1
Mesenchymal Polyps
359
7
Miscellaneous Polypoid Lesions
366
15
SECTION IV EPITHELIAL NEOPLASMS OF THE GI TRACT
381
124
Epithelial Neoplasms of the Esophagus
381
28
Jonathan N. Glickman
Robert D. Odze
Benign Neoplasms and Tumor-like Lesions
381
5
Malignant Neoplasms
386
23
Epithelial Neoplasms of the Stomach
409
20
Gregory Y. Lauwers
Introduction
409
1
Gastric Epithelial Dysplasia
410
3
Gastric Adenocarcinoma
413
16
Epithelial Neoplasms of the Small Intestine
429
12
Amy Noffsinger
Adenomatous Polyps
429
2
Adenomas in Polyposis Syndromes
431
1
Adenocarcinoma
431
2
Crohn's Disease-Associated Adenocarcinoma
433
2
Gluten-Sensitive Enteropathy--Associated Adenocarcinoma
435
1
Other Types of Carcinoma
436
1
Gangliocytic Paraganglioma
437
4
Epithelial Neoplasms of the Large Intestine
441
32
Mark Redston
Clinical Features
441
2
Essential Pathogenetic Issues
443
1
Specimen Handling and Gross Features
444
1
Microscopic Features
445
10
Special Studies
455
1
Differential Diagnosis
455
1
Natural History
456
1
Treatment
456
1
Prognostic Factors
456
8
Hereditary Nonpolyposis Colorectal Cancer
464
2
Colitis-Associated Neoplasia
466
1
Sign-out Checklist
467
6
Epithelial Neoplasms of the Appendix
473
10
Norman J. Carr
Theresa S. Emory
Leslie H. Sobin
Hyperplastic Polyps and Mucosal Hyperplasia
473
1
Adenomas
473
2
Adenocarcinoma
475
2
Pseudomyxoma Peritonei
477
1
Goblet Cell Carcinoid
478
2
Tubular Carcinoid
480
3
Neuroendocrine Tumors of the GI Tract and Appendix
483
22
Fiona Graeme-Cook
Introduction
483
1
Morphology of Neuroendocrine Cells
483
1
Neuroendocrine Tumor Nomenclature
484
7
Esophageal Neuroendocrine Tumors
491
1
Gastric Neuroendocrine Tumors
491
5
Duodenal Neuroendocrine Tumors
496
1
Jejunal/Ileal Neuroendocrine Tumors
497
1
Colonic Neuroendocrine Tumors
498
1
Rectal Neuroendocrine Tumors
499
1
Appendiceal Neuroendocrine Tumors
499
6
SECTION V NONEPITHELIAL NEOPLASMS OF THE GI TRACT
505
48
Mesenchymal Tumors of the GI Tract
505
18
John R. Goldblum
Introduction
505
1
Gastrointestinal Stromal Tumors
506
10
Gastrointestinal Autonomic Nerve Tumors
516
1
Smooth Muscle Tumors
516
1
Neural Tumors
516
3
Lipomatous Tumors
519
1
Vascular Tumors
519
4
Lymphoid Tumors of the GI Tract
523
30
Judith A. Ferry
Introduction
523
1
Gastric Marginal Zone B-Cell Lymphoma
524
3
Intestinal Extranodal Marginal Zone B-Cell Lymphoma
527
1
Immunoproliferative Small Intestinal Disease
528
2
Gastric Diffuse Large B-Cell Lymphoma
530
1
Intestinal Diffuse Large B-Cell Lymphoma
531
1
Mantle Cell Lymphoma
531
1
Follicular Lymphoma
532
1
Burkitt's Lymphoma
533
1
Enteropathy-type Intestinal T-Cell Lymphoma
534
4
Complicated Celiac Disease: Refractory Sprue and Ulcerative Jejunitis
538
2
Appendiceal Lymphoma
540
1
Hodgkin's Disease of the Gastrointestinal Tract
540
1
Gastrointestinal Lymphoma in Abnormal Immune States
541
3
Miscellaneous Rare Gastrointestinal Lymphomas
544
1
Hepatic Lymphoma
544
3
Lymphoma of the Gallbladder
547
1
Lymphoma of the Extrahepatic Biliary Tract
547
1
Pancreatic Lymphoma
547
6
SECTION VI ANAL PATHOLOGY
553
474
Inflammatory and Neoplastic Disorders of the Anal Canal
553
16
Christine A. Iacobuzio-Donahue
Embryology and Anatomy of the Anal Canal
553
1
Tumor-like Lesions of the Anus and Anal Canal
554
3
Benign Tumors of the Anus and Anal Canal
557
2
Malignant Neoplasms of the Anal Canal
559
10
PART TWO Gallbladder, Extrahepatic Biliary Tract, and Pancreas
Gallbladder, Extrahepatic Biliary Tract, and Pancreas Tissue Processing Techniques
569
10
James M. Crawford
Introduction
569
1
Pancreas
569
3
Gallbladder
572
3
Extrahepatic Biliary Tract
575
1
Intraoperative Consultation and Frozen Section Analysis
576
3
Diagnostic Cytology of the Pancreas and Biliary Tract
579
20
Barbara A. Centeno
Cytology of the Pancreas
579
15
Cytology of the Biliary Tract
594
5
Developmental Disorders of the Pancreas, Extrahepatic Biliary Tract, and Gallbladder
599
10
Joseph Willis
Structural Anomalies of the Pancreas
599
5
Extrahepatic Biliary Tract
604
1
Gallbladder
605
4
Infectious and Inflammatory Disorders of the Gallbladder and Extrahepatic Biliary Tract
609
30
Jose Jessurun
Stefan Pambuccian
Normal Gallbladder and Extrahepatic Bile Ducts
609
2
Congenital and Developmental Abnormalities
611
2
Gallstones
613
4
Cholecystitis
617
9
Helminth Infestation
626
1
Polyarteritis Nodosa and Other Forms of Vasculitis
626
1
Cholesterolosis
626
1
Hydrops and Mucocele
627
1
Diverticular Disease
628
1
Ischemic Disease
628
1
Traumatic Conditions and ``Chemical'' Cholecystitis
629
1
Biliary Fistulas
629
1
Metachromatic Leukodystrophy
629
1
Inflammatory Disorders of the Extrahepatic Bile Ducts
629
4
Parasitic Infestations of the Biliary Tract
633
1
AIDS-Related Lesions
634
1
Non-neoplastic Biliary Strictures
634
5
Benign and Malignant Tumors of the Gallbladder and Extrahepatic Biliary Tract
639
34
Linda A. Murakata
Jorge Albores-Saavedra
Normal Gallbladder and Extrahepatic Bile Ducts
639
1
Benign Epithelial Tumors of the Gallbladder
640
3
Premalignant Epithelial Lesions of the Gallbladder
643
2
Malignant Epithelial Tumors of the Gallbladder
645
6
Endocrine Tumors of the Gallbladder and Extrahepatic Biliary Tract
651
2
Benign Nonepithelial Tumors of the Gallbladder
653
1
Malignant Mesenchymal Tumors of the Biliary Tract
654
2
Miscellaneous Tumors
656
1
Secondary Tumors of the Gallbladder and Extrahepatic Biliary Tract
657
1
Tumor-like Lesions of the Gallbladder
658
5
Benign Tumors of the Extrahepatic Bile Ducts
663
2
Malignant Tumors of the Extrahepatic Bile Ducts
665
2
Tumor-like Lesions of the Extrahepatic Bile Ducts
667
6
Inflammatory, Infectious, and Other Non-neoplastic Disorders of the Pancreas
673
26
Bruce M. Wenig
Clara S. Heffess
Introduction
673
1
Inflammatory Disorders of the Pancreas
673
14
Infectious Diseases of the Pancreas
687
1
Non-neoplastic Cystic Lesions of the Pancreas
687
4
Congenital and Hereditary Abnormalities of the Exocrine Pancreas
691
2
Age-Related Alterations of the Pancreas
693
6
Benign and Malignant Tumors of the Pancreas
699
40
David S. Klimstra
N. Volkan Adsay
Introduction
699
2
Ductal Adenocarcinoma and Its Variants
701
8
Cysts and Cystic Tumors
709
5
Intraductal Tumors
714
4
Differential Diagnosis of Cystic and Intraductal Lesions
718
1
Acinar Cell Carcinoma, Pancreatoblastoma, and Related Entities
719
2
Endocrine Tumors
721
5
Solid-Pseudopapillary Tumor
726
2
Differential Diagnosis of Solid Cellular Tumors
728
1
Mesenchymal and Lymphoid Tumors
729
1
Tumor-like Lesions
730
1
Secondary Tumors
730
1
Gross Evaluation and the Surgical Pathology Report
731
8
PART THREE Liver
Liver Tissue Processing Techniques
739
18
Lilian B. Antonio
Arief Suriawinata
Swan N. Thung
Liver Biopsy Specimens
739
2
Liver Resection Specimens
741
1
Histochemistry
741
11
Selected Special Procedures
752
5
Diagnostic Cytology of the Liver
757
26
Martha Bishop Pitman
Introduction
757
2
Benign Conditions
759
6
Malignant Neoplasms
765
18
Acute and Chronic Hepatitis
783
28
Laura W. Lamps
Kay Washington
Introduction
783
1
Viral Hepatitis
783
11
Other Viral Infections of the Liver
794
4
Bacterial Infections of the Liver
798
5
Fungal Infections of the Liver
803
1
Parasitic Infections of the Liver
804
7
Autoimmune and Cholestatic Disorders of the Liver
811
22
Kenneth P. Batts
Introduction
811
1
Autoimmune Hepatitis
811
7
Primary Biliary Cirrhosis
818
6
Primary Sclerosing Cholangitis
824
9
Toxic and Drug-Induced Disorders of the Liver
833
30
Paulette Bioulac-Sage
Charles Balabaud
Introduction
833
1
Pertinent Clinical Features
834
2
Categories of Toxic Liver Injury
836
27
Cirrhosis
863
22
Ian R. Wanless
James M. Crawford
Introduction
863
1
Definition
863
1
Pathogenesis
864
5
Morphology
869
6
Histologic Features of Specific Etiologic Subtypes
875
3
Evaluating the Cirrhotic Liver
878
7
Vascular Disorders of the Liver
885
24
Ian R. Wanless
Introduction
885
1
Portal Vein Disease (Portal Vein Obstruction)
886
3
Hepatic Vein Disease (Hepatic Vein Outflow Obstruction)
889
5
Sinusoidal and Microvascular Disease
894
4
Arterial Disease
898
2
Nodular Hyperplasia
900
9
Transplantation Pathology of the Liver
909
58
Anthony J. Demetris
James M. Crawford
Mike Nalesnik
Parmjeet Randhawa
Tong Wu Marida Minervini
Introduction
909
1
Information Helpful in Specimen Evaluation
909
1
Special Considerations for Specific Specimens
910
1
Evaluation of the Donor Liver
911
5
Determination of Causes of Graft Dysfunction After Transplantation
916
27
Recurrent Diseases and Diseases Induced by Transplantation
943
10
Bone Marrow Transplantation: The Hepatic Perspective
953
5
Liver Pathology After Transplantation of Other Solid Organs
958
9
Liver Pathology in Pregnancy
967
12
Kamran Badizadegan
Jacqueline L. Wolf
Introduction
967
1
Clinical and Laboratory Aids in Assessment
967
1
Intrahepatic Cholestasis of Pregnancy
968
2
Acute Fatty Liver of Pregnancy
970
2
Pregnancy-Induced Hypertensive Disorders (Preeclampsia and Eclampsia)
972
1
HELLP Syndrome
972
1
Hepatic Rupture
973
1
Hyperemesis Gravidarum
974
1
Hepatitis E Infection
974
1
Herpesvirus Infections
975
1
Budd-Chiari Syndrome
975
1
Conclusions
975
4
Inherited and Developmental Disorders of the Liver
979
20
A.S. Knisely
James M. Crawford
Introduction
979
1
The Pediatric Liver Biopsy
979
6
Inherited Metabolic Disease in the Adolescent and Adult
985
7
Abnormal Development of the Biliary Tract
992
4
Conclusion
996
3
Benign and Malignant Tumors of the Liver
999
28
Linda D. Ferrell
Introduction
999
1
Tumor Resection Specimens: Reporting
999
1
Hepatocellular Tumors
1000
15
Ductular Lesions
1015
3
Mesenchymal Tumors
1018
6
Hematopoietic Malignancies
1024
1
Other Benign Lesions or Neoplasms
1024
1
Other Malignant Tumors
1024
3
Index
1027