Partial table of contents:

TRISOMY 21: ORIGIN AND PRENATAL SCREENING.

The Origin of Trisomy in Humans (T. Hassold, et al.).

Antenatal Screening for Down Syndrome (N. Wald).

MOLECULAR STRUCTURE OF CHROMOSOME 21.

The Integrated Map of Human Chromosome 21 (D. Patterson).

MENTAL RETARDATION AND ALZHEIMER DISEASE.

Magnetic Resonance Imaging of the Aging Brain in Down Syndrome (J. Emerson, et al.).

PHENOTYPE OF DOWN SYNDROME.

A Hypothesis to Explain the Immune Defects in Down Syndrome (M. Murphy, et al.).

Considerations of Quantitative Data on Organ Sizes and Cell Numbers and Sizes in Down Syndrome (B. Landing & W. Shankle).

MODELS OF DOWN SYNDROME.

Transgenic Models for Chromosome 21 Gene Dosage Effects (Y. Groner).

EPILOGUE.

Epilogue: Toward the Twenty-First Century with Down Syndrome--A Personal View of How Far We Have Come and of How Far We Can Reasonably Expect to Go (C. Epstein).

Index.