Preface

R. R. Ernst

Introduction

High pressure effects on biological macromolecules: from structural changes to alteration of cellular processes

C. Balny

P. Masson

K. Heremans

Revisiting some basic concepts

Pressure-temperature phase diagrams of biomolecules

L. Smeller

The effects of osmotic and hydrostatic pressures on macromolecular systems

J. A. Kornblatt

M.J. Kornblatt

Compressibility of protein transitions

N. Taulier

T.V. Chalikian

Effects of high pressure on enzymatic activity

D. B. Northrop

Major developments in experimental methodology

UV-visible derivative spectroscopy under high pressure

R. Lange

C. Balny

High pressure static fluorescence to study macromolecular structure-function

K. Ruan

C. Balny

Investigation of the effect of high hydrostatic pressure on proteins and lipidic membranes by dynamic fluorescence spectroscopy

P. Tauc

C. R. Mateo

J.-C. Brochon

Tryptophan phosphorescence and pressure effects on protein structure

P. Cioni

G. B. Strambini

Fourier transform infrared spectroscopy in high-pressure studies on proteins

W. Dzwolak

M. Kato

Y. Taniguchi

High-resolution nuclear magnetic resonance studies of proteins

J. Jonas

Synchrotron X-ray and neutron small-angle scattering of lyotropic lipid mesophases, model biomembranes and proteins in solution at high pressure

R. Winter

High pressure simulations of biomolecules

E. Paci

Folding, unfolding and molecular interactions: the high pressure approach

Revisiting volume changes in pressure-induced protein unfolding

C. A. Royer

Expanding the pressure technique: insights into protein folding from combined use of pressure and chemical denaturants

S. Perrett

J.-M. Zhou

High hydrostatic pressure as a tool to study protein aggregation and amyloidosis

T. W. Randolph

M. Seefeldt

J.F. Carpenter

Pressure effects on intra- and intermolecular interactions within proteins

B. B. Boonyaratanakornkit

C. B. Park

D.S. Clark

Pressure induces folding intermediates that are crucial for protein--DNA recognition and virus assembly

J. L. Silva

A. C. Oliveira

A. M. O. Gomes

L. M. T. R. Lima

R. Mohana-Borges

A. B. F. Pacheco

D. Foguel

The interactions of nucleic acids at elevated hydrostatic pressure

R. B. Macgregor Jr.

Experimental and theoretical high pressure strategies for investigating protein--nucleic acid assemblies

T. W. Lynch

S.G. Sligar

Functionality of biosystems under high pressure

Effect of pressure on electron transfer reactions in inorganic and bioinorganic chemistry

J. Macyk

R. van Eldik

High pressure, a tool for exploring heme protein active sites

G. Hui Bon Hoa

M.A. McLean

S.G. Sligar

Cytochrome P-450-CO and substrates: lessons from ligand binding under high pressure

C. Jung

The use of high pressure for applied biochemistry

Cold denaturation of proteins under high pressure

S. Kunugi

N. Tanaka

Protein crystallization under high pressure

Y. Suzuki

G. Sazaki

S. Miyashita

T. Sawada

K. Tamura

H. Komatsu

The use of high pressure for separation and production of bioactive molecules

P. Lemay

Pressure effects on in vivo microbial processes

D. H. Bartlett

Some snapshots for future prospects in basic and applied sciences

Compressibility gives new insight into protein dynamics and enzyme function

K. Gekko

Experiments on ion channels at high pressure

A. G. Macdonald

Cell biology and high pressure: applications and risks

H. Ludwig

Exploring hyperthermophilic proteins under pressure: theoretical aspects and experimental findings

E. Mombelli

E. Shehi

P. Fusi

P. Tortora

High pressure in bioscience and biotechnology: pure science encompassed in pursuit of value

R. Hayashi

Author Index

Subject Index