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Tables of Contents for From Cell to Brain
Chapter/Section Title
Page #
Page Count
Lecturers
ix
 
Seminar Speakers
xi
 
Participants
xiii
 
Preface (French)
xvii
 
Preface (English)
xxiii
 
SECTION I. CYTOSKELETON AND CELL CYCLE
Microtubule Dynamics in vitro and their Relationship with Cellular Function
3
16
D. Job
Introduction
7
1
Basic microtubule dynamics
8
2
Tubulin and microtubules
8
1
Steady state microtubules
9
1
Microtubules and the generation of movement: the polymer biased diffusion model
10
2
Anaphase chromosome movement
10
2
Biased diffusion in the real world
12
1
Microtubules and self organization
12
5
Self organization of rapidly growing microtubules: a diffusion based model
12
2
Microtubule oscillations
14
1
Pattern formation in microtubular solutions
15
2
Conclusion
17
2
References
18
1
Structure and Function of Two Molecular Motors and their Pathways
19
28
R.H. Wade
Introduction
23
1
General properties of muscle and its proteins
24
3
Actin
24
1
Myosin
25
2
Microtubule structure and organisation
27
3
Tubulin
27
1
Microtubule structure
28
2
The kinesin family of motor proteins
30
1
Structure of actin
30
2
The structure of myosin and kinesin
32
4
Low resolution structures
32
1
Structure of myosin
32
1
Structure of kinesin
33
3
Structure of microtubule-kinesin and actin-myosin complexes
36
1
Assaying molecular movement and forces
37
4
How do motor molecules move?
41
6
References
43
4
The Cellular Machinery for Chromosome Movement
47
24
J.R. McIntosh
Background ideas and facts
51
2
The events of mitosis
53
10
Chromosomes become attached to cytoplasmic microtubules
53
5
Chromosomes become arranged so that each chromatid is attached to one centrosome
58
2
Chromosomes become arranged at the equator of the spindle
60
1
Each chromosome separates into two identical parts and these move apart
61
2
The mechanisms for chromosome movement
63
5
Motor enzymes, as well as microtubules, are important for chromosome movement
63
4
Spindle motor enzymes can transduce the energy in assembled MTs into mechanical work to move chromosomes
67
1
Summary and conclusion
68
3
References
69
2
The Role of Microtubules in the Creation of Order in the Cell
71
24
R.L. Margolis
The cytoskeleton and its dynamics
75
3
Origins of microtubule cytoskeletal organization
78
17
Centrosomes/centrioles/basal bodies
78
1
The centrosome and microtubule dynamics
78
2
The centriole-basal body
80
1
The centrosome constituents and their function in microtubule organization
81
2
Centromeres
83
1
Microtubule dynamics and the centromere
83
1
Composition of the centromere
84
2
Independent and highly ordered microtubule arrays
86
1
Microtubule based communication and ordering of cell space
87
2
References
89
6
SECTION II. INTRACELLULAR COMMUNICATION Membranes -- Synapses -- Time
Intracellular Membrane Traffic
95
10
M. McCaffrey
B. Goud
Introduction
99
1
Coated vesicles
99
3
Clathrin coated vesicles
100
1
COP vesicles
101
1
The SNARE hypothesis
102
1
The Rab family of GTPases
103
1
Conclusion
103
2
References
104
1
I: Signaling in Sensory Cells II: Molecular Structure and Function of Ion Channels
105
12
U.B. Kaupp
Signaling in sensory cells
109
4
References
113
1
Molecular structure and function of ion channels
113
4
References
115
2
Theoretical Models for Oscillations in Biochemical and Cellular Systems
117
18
A. Goldbeter
Introduction
121
1
Rhythmic phenomena in biological systems
121
2
Cellular regulation and oscillatory behavior
123
6
Enzymatic regulation: glycolytic oscillations
123
2
Receptor regulation: oscillations of cyclic AMP in Dictyostelium amoebae
125
2
Transport regulation: oscillations of intracellular calcium
127
1
Genetic regulation: circadian rhythms in Drosophila
128
1
Conclusions
129
6
References
130
5
SECTION III. DEVELOPMENT OF THE CENTRAL NERVOUS SYSTEM
An Overview of Nervous System Development
135
24
O. Pourquie
F. Bourrat
Neurogenesis and neural differentiation
139
8
Cell production and cell differentiation in the nervous system
139
1
The proliferative zones: the ventricular neuroepithelia
139
1
The tritiated thymidine method
139
2
Pattern of neuron production
141
1
Neuronal birthdates
141
1
Cell lineage in the CNS
141
1
The general problem of cell lineage
141
1
Cell lineage of Caenorhabditis elegans
142
1
Cell lineage studied by injection of intracellular tracers
143
1
Cell lineage studied with engineered retroviruses
144
1
Other techniques for the study of cell lineage in the CNS
145
1
Neuronal differentiation
145
1
Neuronal phenotype
145
1
Factors determining neuronal phenotypes
145
2
Conclusion
147
1
Neuronal migration and axon growth
147
12
Neuronal migration
148
1
The two main types of neuronal organisation in the vertebrate CNS
148
1
Radial migration and morphogenesis of cortical structures
148
3
Other patterns of neuronal migration
151
1
Axonal migration
152
1
The growth cone, motor of axonal elongation
152
2
Mechanisms of neuritic elongation
154
2
Conclusion
156
1
References
156
3
G-protein Coupled Receptors: Themes and Variations on Membrane Transmission of Extracellular Signals
159
36
P. Vernier
Receptors are essential cell components
163
2
The mechanisms of signal transduction by G-protein coupled receptors
165
10
The activated receptors catalyze the G protein cycle
167
2
Structure--activity relationships in receptor--G protein coupling
169
6
How cells modulate signal transmission by G-protein coupled receptors: from biosynthesis to regulation at the plasma membrane
175
7
Desensitization and down-regulation of G-protein coupled receptors and G proteins
175
4
The biosynthesis and intracellular transport of G-protein coupled receptors
179
3
The molecular diversity of transmission modules at the plasma membrane
182
3
The generation of receptor multiplicity in vertebrates: an evolutionary approach
185
10
Generalities about molecular evolution
186
1
The evolution of bioamine receptors in vertebrates
187
3
References
190
5
SECTION IV. Lectures and Seminars Presented at the Summer School but not Published in the Proceedings
The Endomembrane System
195
6
D.D. Sabatini
Annotated bibliography of the course
199
2
The History of the Two-stage Model for Membrane Protein Folding
201
10
D.M. Engelman
Annotated bibliography relating to the course
205
3
Conclusion
208
3
Post Synaptic Receptors and the Organisation of the Synapse
211
8
R. Kelly
Bibliography relating to the course
215
4
Quantal release
215
1
The SNARE hypothesis
215
1
Calcium regulation
216
1
Synaptic regulation
216
1
Synaptic vesicle biogenesis
217
1
Secretory granule biogenesis
217
1
Synapse adhesion
218
1
Inhibition as Binding Controller at the Level of a Single Neuron (Information Processing in a Pyramidal-type Neuron)
219
8
A.K. Vidybida
Introduction
223
1
Methods
223
1
Results
223
1
Conclusions and discussion
224
3
References
225
2
Isolated Nerve Cell Response to Laser Irradiation and Photodynamic Effect
227
16
A.B. Uzdensky
Introduction
231
1
Object and methods
231
1
Single neuron response to blue laser microirradiation
232
6
Neurophysiological conclusion
238
1
Possible application of stretch receptor neuron for PDT photosensitizers testing
239
4
References
240
3
Short Reports on Ph.D. Student Seminars
243
10
Structure and hydration of bacteriorhodopsin in its M-state studied by neutron diffraction
247
1
Membranes, vesicles and micelles -- a density functional approach
247
1
Elastic properties of the Listeria Moncytogenes tail
248
1
Introduction to indirect detected 13C NMR imaging and spectroscopy
248
1
Crystallographic studies of the small ribosomal 30S subunit from Thermus thermophilus and bovine pancreatic trypsin -- contrast variation and phasing with anomalous dispersion of phosphorus and sulfur
249
4
SECTION V. CONCLUSION
Relations between Physics and Biology
253
4
B. Jacrot
Relations between physics and biology
257
7
References
264