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Tables of Contents for Drug Delivery and Targeting
Chapter/Section Title
Page #
Page Count
Preface
ix
Acknowledgements
xi
Corresponding Authors
xiii
Section 1: Introduction to Advanced Drug Delivery and Targeting
Drug Delivery: The Basic Concepts
Anya M. Hillery
1
48
Introduction
2
1
The concept of bioavailability
3
3
The process of drug absorption
6
24
Pharmacokinetic processes
30
3
Timing for optimal therapy
33
4
Drug delivery considerations for the 'new biotherapeutics'
37
9
Conclusions
46
1
Further reading
47
1
Self-assessment questions
48
1
Drug Delivery: Market Perspectives
Paul Evers
49
14
Introduction
50
1
Commercial importance of advanced drug delivery technologies
50
4
Market analysis
54
6
Industry evolution and structure
60
1
Further reading
61
1
Self-assessment questions
62
1
Advanced Drug Delivery and Targeting: An Introduction
Anya M. Hillery
63
20
Terminology of drug delivery and targeting
64
1
Rate-controlled release in drug delivery and targeting
65
4
Drug targeting systems
69
1
Dosage forms for advanced drug delivery and targeting systems
70
2
Routes of administration
72
6
Strategies to increase drug absorption
78
3
Conclusions
81
1
Further reading
81
1
Self-assessment questions
81
2
Rate control in Drug Delivery and Targeting: Fundamentals and Applications to Implantable Systems
Hongkee Sah and Yie W. Chien
83
34
Introduction
84
1
Advantages and disadvantages of implantation therapy
85
2
Biocompatibility issues
87
1
Non-degradable polymeric implants
88
11
Biodegradable polymeric implants
99
8
Implantable pumps
107
6
Conclusions
113
1
Further reading
114
1
Self-assessment questions
114
3
Drug Targeting Systems: Fundamentals and Applications to Parenteral Drug Delivery
Daan J. A. Crommelin Wim E. Hennink and Gert Storm
117
28
Introduction
118
9
Soluble carriers for targeted drug delivery
127
4
Particulate carriers for drug targeting
131
8
Pharmaceutical aspects of carrier systems
139
3
Conclusions and prospects
142
1
Further reading
142
1
Self-assessment questions
143
2
Section 2: Routes of Drug Delivery
Oral Drug Delivery
Vincent H. L. Lee and Johnny J. Yang
145
40
Introduction
146
1
Structure and physiology of the GI tract
146
4
Physiological factors affecting oral bioavailability
150
8
Formulation factors affecting oral bioavailability
158
5
Advantages and disadvantages of oral drug delivery
163
3
Current technologies in oral drug delivery
166
4
New and emerging technologies in oral drug delivery
170
12
Conclusion
182
1
Further reading
182
1
Self-assessment questions
183
2
Oral Trans-Mucosal Drug Delivery
Janet Hoogstraate Luce Benes Sophie Burgaud Francoise Horriere and Isabelle Seyler
185
22
Introduction
186
1
Structure and physiology of the oral mucosa
186
3
Physiological factors affecting oral transmucosal bioavailability
189
3
Formulation factors affecting oral transmucosal bioavailability
192
1
Advantages and disadvantages of oral transmucosal drug delivery
193
3
Current technologies for oral transmucosal drug delivery
196
2
New and emerging technologies for oral transmucosal drug delivery
198
7
Conclusions
205
1
Further reading
205
1
Self-assessment questions
206
1
Transdermal Drug Delivery
M. Begona Delgado-Charro and Richard H. Guy
207
30
Introduction
208
1
Structure and physiology of the skin
208
3
Factors affecting transdermal bioavailability
211
5
Advantages and disadvantages of transdermal drug delivery
216
1
Current technologies for transdermal drug delivery
217
12
New and emerging technologies for transdermal drug delivery
229
4
Conclusions
233
1
Further reading
234
1
Self-assessment questions
235
2
Nasal Drug Delivery
Alison B. Lansley and Gary P. Martin
237
32
Introduction
238
1
Structure and physiology of the nasal cavity
238
10
Physiological factors affecting nasal bioavailability
248
5
Formulation factors affecting nasal bioavailability
253
3
Advantages and disadvantages of nasal drug delivery
256
2
Current technologies for nasal drug delivery
258
3
New technologies in nasal delivery
261
6
Conclusions
267
1
Further reading
267
1
Self-assessment questions
268
1
Pulmonary Drug Delivery
Glyn Taylor and Ian Kellaway
269
32
Introduction
270
1
Structure and physiology of the lungs
270
5
Barriers to pulmonary drug delivery
275
11
Advantages and disadvantages of pulmonary drug delivery
286
2
Current technologies for pulmonary drug delivery
288
9
New technologies for pulmonary drug delivery
297
2
Conclusions
299
1
Further reading
300
1
Self-assessment questions
300
1
Vaginal Drug Delivery
Hiroaki Okada and Anya M. Hillery
301
28
Introduction
302
1
Structure and physiology of the vagina
303
1
Physiological factors affecting vaginal drug delivery
304
6
Formulation factors affecting vaginal drug delivery
310
2
Advantages and disadvantages of vaginal delivery
312
3
Current technologies in vaginal drug delivery
315
3
New technologies in vaginal drug delivery
318
9
Conclusions
327
1
Further reading
327
1
Self-assessment questions
328
1
Ophthalmic Drug Delivery
Clive G. Wilson Y. P. Zhu P. Kurmala L. S. Rao and B. Dhillon
329
26
Introduction
330
2
Structure and physiology of the eye
332
2
Topical drug delivery
334
12
Intraocular drug delivery
346
6
Conclusions
352
1
Further reading
352
1
Self-assessment questions
353
2
Drug Delivery to the Central Nervous System
William M. Pardridge and Pamela L. Golden
355
16
Introduction
356
1
Structure and function of the blood-brain barrier
356
2
Physiological factors affecting drug delivery to the CNS
358
2
Physicochemical factors affecting drug delivery to the CNS
360
3
Current technologies in CNS drug delivery
363
4
New technologies in CNS drug delivery
367
2
Conclusions
369
1
Further reading
369
1
Self-assessment questions
370
1
Section 3: Future Directions of Drug Delivery and Targeting
Plasmid-based Gene Therapy
Ram I. Mahato and Eric Tomlinson
371
28
Introduction
372
2
Gene expression systems
374
3
Gene delivery systems
377
6
Biodistribution and pharmacokinetics
383
6
Clinical applications of gene therapy
389
6
Conclusion
395
1
Further reading
396
1
Self-assessment questions
396
3
Integrating Drug Discovery and Delivery
David Bailey and Andrew W. Lloyd
399
22
Introduction
400
1
Combinatorial chemistry
400
4
High-throughput screening
404
1
Genomics
405
8
Proteomics
413
2
Pharmacogenomics and pharmacoproteomics
415
1
Exploiting proteomics and genomics in drug targeting
416
1
Bioinformatics
417
1
Conclusions
418
1
Further reading
418
1
Self-assessment questions
419
2
New Generation Technologies
Hongkee Sah Yie W. Chien Haesun Park Sun-Joo Hwang Kinam Park and Andrew W. Lloyd
421
22
Introduction
422
1
Rationalising drug design, discovery and delivery
422
5
The challenge of chronopharmacology
427
13
Epilogue
440
1
Further reading
441
1
Self-assessment questions
441
2
Appendix
443
2
Index
445
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