search for books and compare prices
Tables of Contents for Ribosomal Rna and Group I Introns
Chapter/Section Title
Page #
Page Count
1. The Structural Domains of Group I Introns
1
14
Eric Westhof
Francois Michel
1.1. Of Sequences and Catalysis
1
1
1.2. Structural Domains
2
1
1.3. The Catalytic Domain
3
2
1.4. Interactions Between the Domains
5
5
1.5. Conclusions
10
5
2. Comparative Sequence Analysis of Experiments Performed During Evolution
15
20
Robin R. Gutell
Simon H. Damberger
I. Introduction
15
1
II. Comparative Methods
16
4
III. Databases
20
2
IV. Comparatively Inferred Structures: Principles of RNA Structure
22
6
V. Summary and Perspective
28
7
3. The Elusive Peptidyl Transferase-RNA or Protein?
35
20
Andrea Barta
Isabella Halama
A Simplified Assay for Peptidyl Transferase
35
1
The Search for a Protein Enzyme
36
2
The "Coming Out" of RNA
38
7
Catalyzing Peptide Bond Formation
45
10
4. Ribosomal RNA, Decoding and Ribozymes
55
14
Seth Stern
The Decoding Region as a Fossilized Functional RNA
58
4
Ribosomal Implications
62
5
Closing Comments
67
2
5. Translocation on Ribosomes
69
14
Knud H. Nierhaus
First Possibility: tRNAs in toto Simultaneously Change Sites During the Translocation Reaction
70
3
Second Possibility: tRNAs Can Partially Occupy the Ribosomal Binding Sites--the Hybrid-Site Model
73
4
Third Possibility: The Ribosomal Binding Sites Move the (tRNA)2-mRNA Complex: The a-e Model
77
6
6. Activities of Group I Introns
83
20
Renee Schroeder
Reactions in cis: Self-Splicing
83
6
Reactions in trans
89
5
Using SELEX to Obtain Group I Introns with Modified Activities
94
2
The Group I Intron Can Accelerate the Cleavage of an Aminoacyl Ester
96
1
A Group I Intron Can Function as an RNA Repairing Enzyme In Vivo
96
7
7. Metal Ions as the Key to the Functioning of Both the Group I Intron and the Ribosome
103
26
Barbara Streicher
Mary G. Wallis
Properties of Metals Ions Pertinent to Roles Played in Biological Systems
104
1
Metal Ion Binding Sites in Nucleic Acids
105
1
Group I Introns, Structure and Function
106
5
The Role of Metal Ions in the Attainment and Stabilization of the Folded Catalytically Active Structure
111
1
How are Metal Ions Involved in the Chemical Reactions they Promote?
112
3
Ribosomes
115
1
Metal Ions Influence Structure and Function of Ribosomes, Ribosomal Subunits and Ribosomal RNAs
115
3
Specific Functions of Metal Ions During Translation
118
3
Discussion
121
8
8. Antibiotics that Interfere with RNA/RNA Interactions
129
24
Herbert Wank
Renee Schroeder
1. Aminoglycosides Which Interfere with the Ribosomal A-Site Function
130
1
2. Streptomycin as a Modulator of Translation Accuracy
131
2
3. Competitive Inhibitors of Group I Intron Self-Splicing
133
3
4. Aminoglycosides are Potent Inhibitors of Group I Intron Splicing
136
4
5. Why are the Decoding Site and the Group I Intron Core Targets for the Same Antibiotics?
140
3
6. Inhibitors of Peptidyl Transferase Activity
143
2
7. Viomycin as a "Bridging Agent"
145
1
Perspectives
146
7
9. Extraribosomal Functions of Ribosomal Proteins
153
26
Ira G. Wool
Rat Ribosomal Proteins
154
1
DNA Binding Motifs in Ribosomal Proteins
154
3
On the Origin of the Ribosomal Proteins
157
2
Extraribosomal Functions of Ribosomal Proteins
159
20
10. Aminoacyl tRNA Synthetases Involved in Group I Intron Splicing
179
20
Genevieve Dujardin
Christopher J. Herbert
The N. Crassa Mitochondrial Tyrosyl-tRNA Synthetase
182
4
The S. Cerevisiae Mitochondrial Leucyl-tRNA Synthetase
186
5
Conclusion
191
8
11. Splicing and Evolution of Introns in Ribosomal RNA
199
22
Sarah Woodson
Splicing of rRNA Introns
200
6
Intron Origins and Evolution
206
3
Mechanisms of Intron Transposition
209
3
Summary and Future Prospects
212
9
12. Mobility of Group I Introns
221
22
Mary Bryk
John E. Mueller
The Discovery of Group I Intron Homing
221
3
The Mechanism of Group I Intron Homing
224
6
The Origins of Mobile Group I Introns
230
3
Concluding Remarks
233
10
Index
243