O(2) in Vascular Disease

1. Leukocyte Activation and Toxic Oxygen Metabolites/Free Radicals

Jill J.F. Belch

Paul Hickman

2. Impaired Hemorheology in the Aged Associated with Oxidative Stress

Joseph M. Rifkind

Ranjeet S. Ajmani

Jane Heim

3. Measurements of Oxygen Saturation in Normal Human Sural Nerve by Microlightguide Spectrophotometry and Endoscopy

N.D. Harris

S. Ibrahim

M. Radatz

J.D. Ward

4. Microvascular Blood Flow and Oxygen Supply in Ulcerated Skin of the Lower Limb

D.J. Newton

D.K. Harrison

G.B. Hanna

C.J.A. Thompson

J.J.F. Belch

P.T. McCollum

5. Skin Oxygenation Following Groin Incision for Femoro-Popliteal Bypass Surgery

Z. Raza

D.J. Newton

D.K. Harrison

P.T. McCollum

P.A. Stonebridge

6. Near Infrared Time Resolved Spectroscopy for the Detection of Deep Vein Thrombosis within the Human Leg

Jamie T. Barnett

Mark W. Hemelt

Duane F. Bruley

Kyung A. Kang

7. Incidence of Asymptomatic Peripheral Arterial Occlusive Disease in Diabetic Patients Attending a Hospital Clinic

T.A. Elhadd

R.T. Jung

R.W. Newton

P.A. Stonebridge

J.J.F. Belch

8. Cutaneous Microvascular Responses Are Improved after Cholesterol-Lowering in Patients with Peripheral Vascular Disease and Hypercholesterolaemia

Faisel Khan

Sturat J. Litchfield

Jill J.F. Belch

O(2) Transport in Tumours

9. Oxygen Tension in Primary Tumours of the Uterine Cervix and Lymph Node Metastases of the Head and Neck

Heidi Lyng

Kolbein Sundfor

Gunnar Tanum

Einar K. Rofstad

10. Measurement of Hypoxia in Vivo Using a 2-Nitromidazole (NITP)

R.J. Hodgkiss

L. Webster

G.D. Wilson

11. NIR Reflection Measurements of Hemoglobin and Cytochrome aa(3) in Healthy Tissue and Tumors: Correlations to Oxygen Consumption: Preclinical and Clinical Data

F. Steinberg

H.J. Rohrborn

T. Otto

K.M. Scheufler

C. Streffer

12. Tumor Oxygenation under Normobaric and Hyperbaric Hyperoxia: Impact of Various Inspiratory CO(2) Concentrations

O. Thews

D.K. Kelleher

P. Vaupel

13. Blood Flow and Oxygenation Status of Head and Neck Carcinomas

Peter Vaupel

14. Intratumoral pO(2) Measured Using a New Oxygen Sensitive Paramagnetic Material, Gloxy

Philip E. James

Julia A. O'Hara

Oleg Y. Grinberg

Tomasz Panz

Harold M. Swartz

15. Determining the Anatomic Position and Histological Effects in Murine Tumors of Gloxy, an Oxygen-Sensitive Paramagnetic Material

Julia A. O'Hara

Philip E. James

Youssef Zaim Wadghiri

Tomasz Panz

Oleg Y. Grinberg

Neelu Jain

Jeffrey F. Dunn

Harold M. Swartz

16. In Vivo Investigations of Vascular Density and Local Mitochondrial Metabolism after Irradiation

Ludwig Plasswilm

Jens Hoper

17. Effect of Cell Line and Differentiation on the Oxygenation Status of Experimental Sarcomas

O. Thews

D.K. Kelleher

B. Lecher

P. Vaupel

Hyperoxia and Hypoxia

18. New Horizons in Hyperbaric Oxygenation

Philip B. James

19. Clinical Hyperbaric Medicine and the WWW Question

A.J. van der Kleij

20. Gas Exchange and Gas Transport in a Water Breather of Millimetre Size

Ralph Pirow

Frank Wollinger

Rudiger J. Paul

21. Response of Purine Metabolism and Cortical Oxygen Pressure to Hypoxia and Reoxygenation in Newborn Piglets

Peter Pastuszko

Peter Marro

Maria Delivoria-Papadopoulos

David F. Wilson

22. Rapid Ischemic Preconditioning Protects Rats from Cerebral Anoxia/Ischemia

Miguel A. Perez-Pinzon

Guang-Ping Xu

Patricia L. Mumford

W. Dalton Dietrich

Myron Rosenthal

Thomas J. Sick

23. Brain Metabolic and Vascular Adaptations to Hypoxia in the Rat: Review and Update

Joseph C. LaManna

Sami I. Harik

24. Influence of Environmental Oxygen Concentration on Enlargement and Vascular Density of the Area vasculosa in Chick Embryos

Jens Hoper

Herbert Jahn

Resit Demir

Kirsten Hoper

25. Nitric Oxide and Endothelin in Acute Hypoxic Pulmonary Vasoconstriction and Adaptation to Chronic Hypoxia

W.L. Rumsey

B.M. Abbott

D.L. Bertelsen

M.A. DeSiato

O(2) Transport in Organs: Brain

26. Haemoglobin Oxygenation Changes during Visual Stimulation in the Occipital Cortex

J. Ruben

R. Wenzel

H. Obrig

K. Villringer

J. Bernarding

C. Hirth

H. Heekeren

U. Dirnagl

A. Villringer

27. Mitochondrial Hyperoxidation after Cerebral Anoxia/Ischemia: Epiphenomenon or Precursor to Residual Damage?

Myron Rosenthal

Patricia L. Mumford

Thomas J. Sick

Miguel A. Perez-Pinzon

28. Response of Cortical Oxygen and Striatal Dopamine in Newborn Piglets to Alcohol Infusion under Normoxic and Hypoxic Conditions

Dekun Song

Stephanie J. Murphy

David F. Wilson

Anna Pastuszko

29. Influence of Various Ventilatory Parameters on Nir Reflexion Spectroscopy Based Cerebral Oxygen Measurements: An Experimental Animal Study

K.M. Scheufler

Ch. Thees

F. Steinberg

J. Zentner

30. Continuous Measurement of Cerebral Oxygenation by Nirs during Induction of Anaesthesia

A.T. Lovell

H. Owen-Reece

C.E. Elwell

M. Smith

J.C. Goldstone

31. Measurement of Absolute Cerebral Haemoglobin Concentration in Adults and Neonates

M. Wolf

P. Evans

H.-U. Bucher

V. Dietz

M. Keel

R. Strebel

K. von Siebenthal

32. NIR Reflexion Spectroscopy Based Oxygen Measurements during Intracranial Hypertension in Rabbits: An Experimental Study

K.M. Scheufler

Ch. Thees

F. Steinberg

J. Zentner

33. Human Brain Functional Imaging with Reflectance CWS

S. Nioka

Q. Luo

B. Chance

O(2) Transport in Organs: Heart and Lung

34. Relationship between Regional Myocardial Oxygenation and Function during Acute Ischemia Supported by Selective Suction and Retroinfusion (SSR) in Pigs

G. von Degenfeld

W. Peter, H. Habazettl

M. von Ludinghausen

K. Werdan

P. Boekstegers

35. Post-Ischemic (31)PNMR Determination of Myocardial Intracellular pH in Vivo Using ATP Peak

Ralph J.F. Houston

Arend Heerschap

Stefan H. Skotnicki

Freek W.A. Verheugt

Berend Oeseburg

36. Intramyocardial pO(2) Measured by Epr

Oleg Y. Grinberg

Bruce J. Friedman

Harold M. Swartz

37. Simultaneous Measurement of Oxygen Consumption and (13)C(16)O(2) Production from (13)C-Pyruvate in Diabetic Rat Heart Mitochondria

Nicolai M. Doliba

Ian R. Sweet

Andriy Babsky

Nataliya Doliba

Robert E. Forster

Mary Osbakken

38. Exogenous Surfactant and Nitric Oxide Have a Synergistic Effect in Improving Gas Exchange in Experimental ARDS

A. Hartog

D. Gommers

A. van 't Veen

W. Erdmann

B. Lachmann

39. Partial Liquid Ventilation and Inhaled Nitric Oxide Have a Cumulative Effect in Improving Arterial Oxygenation in Experimental ARDS

A. Hartog

R.J.M. Houmes

S.J.C. Verbrugge

W. Erdmann

B. Lachmann

O(2) Transport in Organs: Skeletal Muscle

40. Blood Oxygen Desaturation Heterogeneity during Muscle Contraction Recorded by Near Infrared Spectroscopy

P.G. Cooper

G.J. Wilson

D.T.A. Hardman

O. Kawaguchi

Y.-F. Huang

A. Martinez-Coll

R.A. Carrington

E. Puchert

R. Crameri

C. Horamand

S.N. Hunyor

41. Determination of the Diffusion Coefficient of Myoglobin in Muscle Cells: Photo-Oxidation and Microinjection Method

Klaus D. Jurgens

Simon Papadopoulos

Thomas Peters

Gerolf Gros

42. In Vivo Analysis of Capillary Leukocyte Trafficking in Striated Muscle Ischemia/Reperfusion

Martin Rucker

Brigitte Vollmar

Michael D. Menger

43. Association of Capillary Diameter Response and Nutritive Perfusion Failure in Postischemic Striated Muscle

Martin Rucker

Brigitte Vollmar

Michael D. Menger

44. Intramuscular Oxygen Partial Pressure in Patients with Chronic Exertional Compartment Syndrome (CECS)

B. Evers

V. Odemis

H. GerngroXXX

45. Oxygen Partial Pressure in the Anterior Tibial Muscle during and after Knee Surgery with Tourniquet Control

B. Evers

V. Odemis

H. GerngroXXX

46. Detection of Oxygen Consumption in Different Forearm Muscles during Handgrip Exercise by Spatially Resolved NIR Spectroscopy

Sachiko Homma

Atsuko Kagaya

47. Skeletal Muscle Function, Oxygenation and Biochemistry in an Endotoxemic Model of SIRS

Ellen Dailor Iannoli

Thomas E.J. Gayeski

Systemic O(2) Transport

48. Increasing Oxygen Consumption and Survival with Fluid Resuscitation Therapy for Hemorrhagic Shock in Rats

Matthew C. Graham

John L. Gainer

49. Increased Oxygen Dissociation by Nitric Oxide from RBC

Hiroaki Kosaka

Akitoshi Seiyama

50. Behavior of Stimulated Leukocytes in the Pulmonary Microcirculation of Perfused Rat Lungs

Takuya Aoki

Yukio Suzuki

Kazumi Nishio

Kouichi Suzuki

Atsusi Miyata

Masaaki Mori

Tomoaki Takasugi

Hirofumi Fujita

Harukuni Tsumura

Yuzuru Ishimura

Makoto Suematsu

Kazuhiro Yamaguchi

51. Effect of Bicarbonate Haemodialysis on Peripheral Oxygen Availability in Mild Hypertensive Patients

G. Cicco

A.J. van der Kleij

G. Passavanti

G. Baldassare

A. Manicone

P. Vicenti

M. Marra

P. Izzo

P. Coratelli

A. Pirelli

52. Subcutaneous and Splanchnic Tissue Perfusion during Hypovolemia Evaluated by Tissue Gases and pH Measurements

Michael Hartmann

Ake Mellstrom

Kent Jonsson

53. Relationship between Hemoglobin Oxygenation and Anemia

Marcus Gliwitzki

Rainer Gross

Klaus Pietrzik

Imelda Winoto

Soemilah Sastroamidjojo

54. Peripheral Oxygen Supply in Children during Therapy with Human Growth Hormone (hGH)

Kirsten Hoper

H.G. Dorr

J. Hoper

55. Oxygenation of the Intestinal Mucosa in Anaesthetized Dogs Is Attenuated by Intermittent Positive Pressure Ventilation (IPPV) with Positive End-Expiratory Pressure (PEEP)

A. Fournell

T.W.L. Scheeren

L.A. Schwarte

56. Measurement of Cerebral Oxygenation and Haemodynamics during Haemorrhage/Fluid Replacement

M.S. Thorniley

K.S. Khaw

E. Balogun

S. Simpkin

C. Shurey

I.A. Sammut

C.J. Green

57. Monitoring of Microvascular Hemoglobin Oxygenation in Liver and Skeletal Muscle Tissue of Endotoxin-Exposed Rats Using Reflection Spectrophotometry

Brigitte Vollmar

Dominik Ruttinger

Michael D. Menger

58. Assessment of Microvascular Oxygen Supply and Tissue Oxygenation in Hepatic Ischemia/Reperfusion

Brigitte Vollmar

Michael D. Menger

59. Oxygen Saturation of Intracapillary Haemoglobin in Patients with Systemic JCA (Still's Disease)

J.P. Haas

K. Hoper

G. Leipold

H.G. Dorr

J. Hoper

Local Regulation of O(2) Supply

60. Oxygen Dependent Regulation of Capillary Flow: Fact or Fiction?

Jens Hoper

Manfred Kessler

Ronie Abi Raad

Richard Funk

61. Heterogeneity of Brain Oxidative Metabolism and Hypoxia Response: Mammalian Systems and Nature's Solutions

Jeff F. Dunn

Eric S. Rhodes

Tomasz Panz

62. Effectiveness of the Peripheral Chemoreflex Control System in the Adjustment of Arterial O(2) Pressure and O(2)-Hb Saturation

H. Kiwull-Schone

P. Kiwull

63. Effect of XXX-Interferon on Vascular Density, Mitochondrial Metabolism and Alkaline Phosphatase in Normoxia and Hypoxia

Resit Demir

Jens Hoper

Cellular Metabolic State in Vivo

64. The Cytochrome Oxidase Redox State in Vivo

Chris Cooper

Martyn Sharpe

Clare Elwell

Roger Springett

Juliet Penrice

Lidia Tyszczuk

Philip Amess

John Wyatt

Valentina Quaresima

David Delpy

65. Hypoxia/Ischemia Triggers a Light Scattering Event in Rat Brain

Britton Chance

Avraham Mayevsky

Bin Guan

Yutao Zhang

Fluorocarbons

66. Simulation of the Oxygen Distribution in Brain Tissue Perfused with Fluorocarbons

R. Stingele

B. Wagner

D.A. Wilson

R.C. Koehler

D.F. Hanley

R.J. Traystman

67. Synergistic Effects of Haemoglobin and Pluronic(R) F-68 on Mitotic Division of Cultured Plant Protoplasts

P. Anthony

K.C. Lowe

M.R. Davey

J.B. Power

68. Post-Thaw Recovery of Cryopreserved Cells: Enhanced Viability by Oxygenated Perfluorocarbon or Pluronic(R) F-68

P. Anthony

K.C. Lowe

M.R. Davey

J.B. Power

69. Novel Fluorosurfactants for Perfluorochemical Emulsification: Effects on Aggregation of Human Platelets in Vitro and Possible Applications as Anti-Thrombotic Agents

C.M. Edwards

K.C. Lowe

S. Heptinstall

P. Lucas

H. Trabelsi

A. Cambon

70. Perfluorochemical Effects on Neutrophil Chemiluminescence

K.C. Lowe

C.M. Edwards

W. Rohlke

P. Reuter

U. Geister

H. Meinert

71. Cellular Responses of Plant Protoplasts to Culture with Oxygenated Perfluorocarbon

J. Wardrop

C.M. Edwards

K.C. Lowe

M.R. Davey

J.B. Power

72. Perfluorochemical-Facilitated Carbon Dioxide Delivery Enhances Growth of Shoots in Vitro

J. Wardrop

R. Marchant

K.C. Lowe

M.R. Davey

J.B. Power

Functional Imaging

73. Regulation of Oxygen Supply in the Cerebral Circulation

Antal G. Hudetz

74. Optical Imaging and Measuring of Local Hemoglobin Concentration and Oxygenation Changes during Somatosensory Stimulation in Rat Cerebral Cortex

Masahito Nemoto

Yasutomo Nomura

Mamoru Tamura

Chie Sato

Kiyohiro Houkin

Hiroshi Abe

75. Influence of Repeated Ischaemia/Reperfusion Cycles (Ischaemic Preconditioning) on Human Calf Energy Metabolism by Simultaneous Near Infrared Spectroscopy, (31)P-NMR and (23)Na-NMR Measurements

T. Binzoni

V. Quaresima

E. Hiltbrand

L. Gurke

P. Cerretelli

M. Ferrari

Perfusion and Diffusion Imaging and Spectroscopy

76. NMR Studies of Hypoxic-Ischaemic Injury in Neonatal Brain Using Imaging and Spectroscopy

R. Ordidge

J. Thornton

M. Clemence

S. Punwani

E. Cady

J. Penrice

P. Amess

J. Wyatt

77. Magnetic Resonance Spectroscopy in Disorders of O(2) Delivery and Utilisation

David G. Gadian

78. NIR Reflection Spectroscopy Based Oxygen Measurements and Therapy Monitoring in Brain Tissue and Intracranial Neoplasms: Correlation to MRI and Angiography

F. Steinberg

H.-J. Rohrborn

K.M. Scheufler

S. Asgari

H.A. Trost

V. Seifert

D. Stolke

C. Streffer

79. An Analytical Method for Determining Cerebrovascular Transit Time Using Near Infrared Spectroscopy

C.E. Elwell

M. Cope

D.T. Delpy

Methods and Instrumentation

80. Measurement of Oxygen Tensions in the Abdominal Cavity and in the Skeletal Muscle Using 19F-MRI of Neat PFC Droplets

J. Lutz

U. Noth

S.P. Morrissey

H. Adolf

R. Deichmann

A. Haase

81. Skin Oxygen Saturation Imager

D.J. Clark

T.J.H. Essex

B. Cater

82. An in-Line Oxygen Gas-Fraction Sensor for Anesthesia and Intensive Care

P.E.M. Huygen

A. Hartog

C. Kolle

E. Oosterbosch

B. Lachmann

83. Imaging Hypoxia and Blood Flow in Normal Tissues

Cameron J. Koch

Edith M. Lord

Irving M. Shapiro

Ronald I. Clyman

Sydney M. Evans

84. Imaging Hypoxia in Diseased Tissues

S.M. Evans

M. Bergeron

D.M. Ferriero

F.R. Sharp

H. Hermeking

R.N. Kitsis

D.L. Geenen

S. Bialik

E.M. Lord

C.J. Koch

85. Fluorescence Lifetime Imaging of the Skin Po(2) Supply: Instrumentation and Results

Paul Hartmann

Werner Ziegler

Dietrich W. Lubbers

86. Effect of Lipopolysaccharide on Intra-Phagosomal Oxygen Concentration as Measured by EPR Oximetry

Simon K. Jackson

Philip E. James

Harold M. Swartz

87. Protein C Detection via Fluorophore Mediated Immuno-Optical Biosensor

James O. Spiker

Kyung A. Kang

William Drohan

Duane F. Bruley

88. Predicting Oscillation in Arterial Saturation from Cardiorespiratory Variables: Implications for the Measurement of Cerebral Blood Flow with NIRS during Anaesthesia

A.T. Lovell

H. Owen-Reece

C.E. Elwell

M. Smith

J.C. Goldstone

89. Separation of Protein C from Fraction IV of the Cohn Process Using Immobilized Metal Affinity Chromatography

Sriram S. Tadepalli

Duane F. Bruley

Kyung A. Kang

William Drohan

90. Blood Oxygenation: Heterogeneity of Hypoxic Tissues Monitored using Bold MR Imaging

Jeff F. Dunn

Harold M. Swartz

91. A New, Water Soluble, Phosphor for Oxygen Measurements in Vivo

Leu-Wei Lo

Sergei A. Vinogradov

Cameron J. Koch

David F. Wilson

92. "Dendritic" Porphyrins: New Protected Phosphors for Oxygen Measurements in Vivo

Sergei A. Vinogradov

David F. Wilson

93. What Does EPR Oximetry with Solid Particles Measure-and How Does This Relate to Other Measures of Po(2)?

Harold M. Swartz

Jeff Dunn

Oleg Grinberg

Julia O'Hara

Ted Walczak

Theoretical Models

94. Mathematical Modelling of Tumour Growth and Angiogenesis

B.D. Sleeman

95. Extraction Pressures Calculated for Rat Heart and Dog Skeletal Muscle and Application in Models of Tissue Oxygenation

L. Hoofd

C. Bos

96. Diameter Control in the Arteriolar Tree by Changes in Post-Capillary Resistance: A Theoretical Study

Karlfried Groebe

97. On the Contribution of Respiratory Gases to Cerebral Autoregulation

D.A. Wilson

98. Temporal Fluctuations in Regional Red Blood Cell Flux in the Rat Brain Cortex Is a Fractal Process

A. Eke

P. Herman

J.B. Bassingthwaighte

G.M. Raymond

I. Balla

C. Ikrenyi

Author Index

Subject Index