Part I. Histological and Immunological Characterization of Thymic Epithelial Tumors and Their Differential Diagnoses

1. Classification of Thymic Epithelial Neoplasms

Nancy Lee Harris

2. Thymic Carcinoma

Yukio Shimosato

3. Thymoma/Thymic Carcinoma: A Distinctive, Unusual Morphologic Entity

Cesar A. Moran

4. A Clinicopathological Study of Thymomas in Singapore

Ivy Sng

Puay Hoon Tan

5. Thymoma: A Clinicopathologic Study of 60 Cases

Alessandra Cancellieri

Alberto Cavazza

Giorgio Gardini

Maurizio Boaron

Nicola Santelmo

Giuseppe Baruzzi

6. p53-Alterations in Thymic Epithelial Tumors

G. Weirich

P. Schneider

C. Fellbaum

H. Brauch

W. Nathrath

M. Scholz

H. Prauer

H. Hofler

7. p53 Protein Expression in Thymic Epithelial Tumors

Naoki Hino

Kazuya Kondo

Takanori Miyoshi

Tadashi Uyama

Yasumasa Monden

8. p53 Overexpression and Thymoma Prognosis

Achille Pich

Roberto Chiarle

Luigi Chiusa

Manuela Motta

Giorgio Palestro

9. Metallothionein Expression in Thymomas: A Tumor Maker for Spindle and Squamoid Thymoma Cells

Tseng-tong Kuo

Sin-Kai Lo

10. Cytokeratin (CK) Profile in Thymomas: CK 10 Is a Marker for Cortical Thymomas and CK 20 a Marker for Medullary Thymomas

J. P. Enoksson

M. Albertsson

A. Cervin

K. Fristrom

L. Johansson

11. Neuroendocrine Differentiation in Thymic Epithelial Tumors: Immunohistochemical Studies

Tsunekazu Hishima

Masashi Fukayama

Yukiko Hayashi

Takeshi Fujii

Katsumi Arai

Yumiko Shiozawa

Nobuaki Funata

Morio Koike

12. Microscopic Thymoma and Myasthenia Gravis: A Clinicopathological and Immunohistochemical Study of Two Cases

F. Puglisi

C. Di Loreto

N. Finato

C. Marchini

C. A. Beltrami

13. Complex and Differential Cytokeratin Profiles in Thymomas and Correlation with Normal Thymus

Kerstin Grommisch

Walter J. Hofmann

Herwart F. Otto

Kirsten Willgeroth

Roland Moll

14. Unusual Recurrence of Mixed Thymoma in Breast

I. C. Kiricuta

Th. Kirchner

15. Histiocytosis - X of the Thymus: Development of Myelomonocytic Leukemia 5 Years after Thymectomy

Wieslaw T. Dura

Malgorzata J. Dura

Part II. Altered T Cell Functions in Thymic Epithelial Tumors

16. T Cell Development in the Human Thymus

Bart Vandekerckhove

Dominique Vanhecke

Jean Plum

17. Intrathymic Autoantigens and Their Role in the Shaping of the Autoimmune T Lymphocyte Repertoire

Hartmut Wekerle

Monika Bradl

Georg Kaab

Kimikazu Kojima

Christopher Linington

Alexander Marx

Scott Peterson

Markus Reindl

18. T Cell Epitopes of the Acetylcholine Receptor and the Pathogenesis of Myasthenia Gravis

Arthur Melms

Robert Weissert

Alexej Schmidt

Claudia Muller

Gunther Jung

Georg Malcherek

19. Thymus in Thymoma-Associated Myasthenia Gravis: Transplantation of Thymoma and Extrathymomal Thymic Tissue into SCID Mice

A. Sarropoulos

A. Marx

R. Hohlfeld

H. Wekerle

S. Spuler

20. Thymic Tumor Progression in SV40T Transgenic Mice Model: Suggestion of Thymoma-Thymic Carcinoma Sequence

Seung-Sook Lee

Ja-June Jang

Jeong Wook Seo

Chul Woo Kim

Sung Hoe Park

Jeong-Sun Seo

Je Geun Chi

21. Analysis of a Murine Thymic Carcinogenesis Model Induced by the Expression of Large T of SV40

Thierry Molina

Lucile Miquerol

Geoffroy de Ribbains

Mounir Bouleksibat

Catherine Martinon

Sophie Ezine

Alain Vandewalle

Jacques Diebold

Axel Kahn

22. Inefficient Positive Selection of CD4+T Cells in Epithelial Cell Tumors of the Human Thymus

Yukiyasu Takeuchi

Yoshitaka Fujii

Meinoshin Okumura

Hikaru Matsuda

23. Abnormal T Lymphocyte Development in Myasthenia Gravis-Associated Thymomas

Regina Nenninger

Anja Schultz

Bart Vandekerckhove

Thomas Hunig

Berthold Schalke

Hans Konrad Muller-Hermelink

Alexander Marx

24. Oligoclonal Peripheral T-Cell Lymphocytosis as a Result of Aberrant T-Cell Development in a Cortical Thymoma

Daphne De Jong

Dick Richel

Cees Schenkeveld

Lucie Boerrigter

Laura van 't Veer

25. Estrogens Modulate IL-6 Production by Cultured Normal and Pathological Human Thymic Epithelial Cells

A. P. Riviera

F. Scuderi

C. Provenzano

M. P. Marino

S. Gallucci

E. Bartoccioni

F. O. Ranelletti

G. Tridente

Part III. Paraneoplastic Autoimmunity

26. Thymoma and Autoimmune Neurological Disorders: A Search for Missing Links in Pathogenesis

Angela Vincent

Nick Willcox

Ioannis Roxanis

John Newsom-Davis

Cal McLennan

David Beeson

27. T-Cell Derived Mechanisms in the Pathogenesis of Myasthenia Gravis

Ann Kari Lefvert

28. Thymomas Express Ryanodine Receptor Epitopes

Ase Mygland

Goro Kuwajima

Katsuhiko Mikoshiba

Johan A. Aarli

Nils Erik Gilhus

29. Titin Epitope in Thymoma

A. Wilisch

A. Schultz

A. Jung

T. Kirchner

B. Schalke

K. V. Toyka

V. Pallini

S. Tzartos

H. K. Muller-Hermelink

A. Marx

30. Accessory Molecule Expression in Human Thymomas and Thymus

S. Appiah-Boadu

J. A. Aarli

G. O. Skeie

N. E. Gilhus

31. CD40-Expression in Thymoma

A. Schultz

A. Greiner

R. Nenninger

D. Schomig

A. Wilisch

E. Oswald

R. A. Kroczek

B. Schalke

H. K. Muller-Hermelink

A. Marx

32. Myasthenia Gravis with Thymoma and Fas Antigen

S. Kawanami

S. Mori

S. Yoneda

T. Shirakusa

K. Nishimaru

M. Kikuchi

33. Myasthenia Gravis Patients Have a Cellular Immune Response against Titin

Geir Olve Skeie

Johan A. Aarli

Roald Matre

Alexandra Freiburg

Nils Erik Gilhus

34. Tumor Necrosis Factor Gene Polymorphisms in Thymoma and Non-Thymoma Myasthenia Gravis

M. M. Lino

G. Zelano

A. P. Batocchi

A. Evoli

P. Tonali

Part IV. Diagnosis and Therapy of Thymic Epithelial Tumors

35. Clinical Immunology of Thymic Tumors in Patients with Myasthenia Gravis

Johan A. Aarli

36. Myasthenia Gravis with Thymoma

H. J. G. H. Oosterhuis

J. B. M. Kuks

37. Reproducibility of a Histogenetic Classification of Thymic Epithelial Tumours

Pauline M. Close

Thomas Kirchner

Cornelius J. Uys

Hans Konrad Muller-Hermelink

38. Morphology of Thymic Remnants Removed after Video-Assisted Thoracoscopic Extended Thymectomy in Patients with Thymomatous Myasthenia Gravis

R. Scelsi

M. Paulli

U. Gianelli

M. T. Ferro'

M. Longoni

L. Novellino

G. Pezzuoli

39. Core Needle Biopsy of Anterior Mediastinum Masses

M. Boaron

S. Artuso

N. Lacava

N. Santelmo

M. Sartini

V. Poletti

A. Cancellieri

G. Baruzzi

40. Cyclin-Dependent Kinase 6 (PLSTIRE) Expression in Normal Thymus, Thymomas, and T-Cell Lymphoblastic Lymphoma

Marco Chilosi

Claudio Doglioni

Maurizio Lestani

Fabio Menestrina

Serena S. T. Pedron

Alice Benedetti

Luca Morelli

Vittorio Rucco

Giovanni Pizzolo

41. Our Approach in the Preparation for Thymectomy in Myasthenia Gravis

Jose M. Ponseti

Eloy Espin

Jose M. Fort

Carlos Vicens

Manuel Armengol

42. Onset of Myasthenia Gravis after Thymectomy for Thymoma

F. Tezzon

M. G. Passarin

T. Zanoni

G. Furlan

G. Ferrari

Part V. Management of Thymectomized Patients

43. Aspects of Clinical Preparation of Thymectomy in Myasthenic Cases with or without Thymoma and the Clinico-Biological Follow-up of the Thymectomized Patients

Paolo Confalonieri

Renato Mantegazza

Carlo Antozzi

Lorenzo Novellino

Giuseppe Pezzuoli

Maria Teresa Ferro'

Manlio Sgarzi

Ferdinando Cornelio

44. Long-Term Prognosis of Patients with Thymoma-Associated Myasthenia Gravis

B. C. G. Schalke

I. Schmitt

A. Marx

K. Toyka

H. K. Muller-Hermelink

45. Thymoma and Myasthenia Gravis: Incidence of Tumor Recurrences in 126 Patients

A. Evoli

A. P. Batocchi

M. T. Palmisani

L. Lauriola

G. B. Doglietto

P. Tonali

46. Thymoma--Prognostic Factors and Outcome

K. Fristrom

A. Cervin

J. P. Enoksson

M. Albertsson

L. Johansson

47. Management of Thymectomised Myasthenic Patients

W. A. Nix

H. GroBe-Hootmann

T. Kirchner

A. Marx

48. Management of Thymectomized Myasthenic Patients

L. Fornadi

R. Horvath

A. Szobor

49. Therapeutic Options in Locally Advanced Thymoma

Patrick J. Loehrer

Mauro Antimi

Andrew Turrisi

Giuseppe Giaccone

50. The Role of Radiotherapy in Treatment of Thymoma

U. Oppitz

D. Latz

M. Flentje

Authors and Sponsors

Index