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Tables of Contents for Laboratory Animal Medicine
Chapter/Section Title
Page #
Page Count
Bennett J. Cohen
ix
List of Contributors
xi
Preface
xv
List of Reviewers for Chapters in This Volume
xvii
Laboratory Animal Medicine: Historical Perspectives
Franklin M. Loew
Bennett J. Cohen
Introduction
1
1
Origins of Animal Experimentation
2
1
Early Veterinarians in Laboratory Animal Science and Medicine
3
4
The Organizations of Laboratory Animal Science
7
6
Education and Training in Laboratory Animal Medicine
13
1
Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine
14
1
Regulation of Animal Research in the United Kingdom and Canada
15
1
Commercial and Academic Breeding of Rodents
15
1
Conclusion
15
4
References
16
3
Laws, Regulations, and Policies Affecting the Use of Laboratory Animals
Lynn C. Anderson
Introduction
19
1
Animal Welfare
20
9
Importation and Exportation of Animals and Animal Products
29
2
Hazardous Substances
31
1
Recombinant DNA Research Guidelines
31
4
References
32
3
Biology and Diseases of Mice
Robert O. Jacoby
James G. Fox
Muriel Davisson
Introduction
35
6
Biology
41
12
Diseases
53
68
References
113
8
Biology and Diseases of Rats
Dennis F. Kohn
Charles B. Clifford
Introduction
121
2
Biology
123
11
Diseases
134
34
References
158
10
Biology and Diseases of Hamsters
F. Claire Hankenson
Gerald L. Van Hoosier, Jr.
Syrian Hamster
168
1
Introduction
168
5
Biology
173
7
Diseases
180
10
Chinese Hamster
190
1
Introduction
190
1
Biology
190
1
Diseases
191
2
Armenian Hamster
193
1
Introduction
193
1
Biology
194
1
Diseases
194
1
European Hamster
194
1
Introduction
194
1
Biology
194
1
Diseases
195
1
Djungarian Hamster
196
1
Introduction
196
1
Biology
196
1
Diseases
196
7
References
197
6
Biology and Diseases of Guinea Pigs
John E. Harkness
Kathleen A. Murray
Joseph E. Wagner
Introduction
203
3
Biology
206
6
Diseases
212
36
References
241
7
Biology and Diseases of Other Rodents
Thomas M. Donnelly
Fred W. Quimby
Introduction
248
2
Ground Squirrels or Susliks: Spermophilus
250
4
Prairie Dogs: Cynomys
254
3
Pocket Gophers: Geomyidae
257
2
Kangaroo Rats: Dipodomys
259
2
Wood Rats or Pack Rats: Neotoma
261
2
Grasshopper Mice: Onychomys
263
2
White-Footed Mice or Deer Mice: Peromyscus
265
2
Rice Rats: Oryzomys
267
1
Cane Mice: Zygodontomys
268
2
Cotton Rats: Sigmodon
270
2
White-Tailed Rats: Mysrromys
272
3
Gerbils and Jirds: Meriones
275
4
Voles and Meadow Mice: Microtus
279
2
Multimammate Rats: Mastomys
281
3
Degus or Trumpet-Tailed Rats: Octodon
284
2
Chinchillas: Chinchilla
286
23
References
291
18
Woodchucks as Laboratory Animals
Christine A. Bellezza
Patrick W. Concannon
William E. Hornbuckle
Lois Roth
Bud C. Tennant
Introduction
309
3
Biology
312
7
Diseases
319
10
References
327
2
Biology and Diseases of Rabbits
Mark A. Suckow
David W. Brammer
Howard G. Rush
Clarence E. Chrisp
Introduction
329
2
Biology
331
8
Diseases
339
26
References
358
7
Microbiological Quality Control for Laboratory Rodents and Lagomorphs
William R. Shek
Diane J. Gaertner
Overview
365
1
Introduction
366
1
Biosecurity
366
6
Microbiological (Health) Surveillance
372
23
References
387
8
Biology and Diseases of Dogs
Robert C. Dysko
Jean A. Nemzek
Stephen I. Levin
George J. DeMarco
Maria R. Moalli
Introduction
395
2
Biology
397
8
Diseases
405
55
References
454
6
Domestic Cats as Laboratory Animals
Brenda Griffin
Henry J. Baker
Introduction
460
2
Sources of Cats
462
1
Housing
463
3
Breeding Colony Management
466
8
Nutrition and Feeding
474
1
Infectious Disease Exclusion and Control
475
8
References
480
3
Biology and Diseases of Ferrets
Robert P. Marini
Glen Otto
Susan Erdman
Lori Palley
James G. Fox
Introduction
483
2
Biology
485
5
Diseases
490
29
References
513
6
Biology and Diseases of Ruminants: Sheep, Goats, and Cattle
Margaret L. Delano
Scott A. Mischler
Wendy J. Underwood
Introduction
519
6
Biology
525
12
Diseases
537
78
References
611
4
Biology and Diseases of Swine
Kathy E. Laber
Mark T. Whary
Sarah A. Bingel
James A. Goodrich
Alison C. Smith
M. Michael Swindle
Introduction
615
3
Biology
618
11
Diseases
629
47
References
665
11
Nonhuman Primates
Bruce J. Bernacky
Susan V. Gibson
Michale E. Keeling
Christian R. Abee
Introduction
676
1
Taxonomy
677
3
Biology
680
35
Principles of Colony Management
715
9
Medical Management
724
6
Diseases
730
63
References
777
16
Biology and Diseases oi Amphibians
Dorcas P. O'Rourke
Terry Wayne Schultz
Introduction
793
8
Biology
801
13
Diseases
814
13
References
823
4
Biology and Diseases of Reptiles
Dorcas P. O'Rourke
Juergen Schumacher
Introduction
827
10
Biology
837
11
Diseases
848
14
References
857
5
Biology and Management of the Zebrafish
Keith M. Astrofsky
Robert A. Bullis
Charles G. Sagerstrom
Introduction
862
1
Experimental Model in Biomedical Research
863
3
Health Management in the Aquatic Animal Facility
866
1
Environmental Factors Important to Health
866
8
Nutrition and Feeding
874
1
Acquisition
875
1
Infectious Diseases
875
11
References
882
4
Biology and Health of Laboratory Fishes
Michael K. Stoskopf
Introduction
886
1
Facility Design
886
7
Management and Husbandry
893
1
Medical Protocols
894
4
Zoonotic Considerations
898
1
Diseases
899
10
References
907
2
Design and Management of Animal Facilities
Jack R. Hessler
Steven L. Leary
Introduction
909
1
Facility Planning and Design
910
21
Equipment
931
15
Commissioning and Validation
946
1
Management
946
1
Conclusions
947
9
References
948
8
Preanesthesia, Anesthesia, Analgesia, and Euthanasia
M. Michael Swindle
George A. Vogler
Linda K. Fulton
Robert P. Marini
Sulli Popilskis
Introduction
956
1
Rodents
956
10
Rabbits
966
7
Dogs
973
6
Swine
979
7
Small Ruminants
986
4
Nonhuman Primates
990
16
References
997
9
Techniques of Experimentation
Robert J. Adams
Introduction
1006
1
Identification Methods
1006
2
Blood Collection and Intravenous Injection
1008
5
Vascular Cannulation
1013
2
Intraperitoneal Injection
1015
1
Subcutaneous and Intramuscular Injection
1015
1
Digestive System
1015
4
Urinary System Techniques
1019
2
Respiratory System Techniques
1021
2
Reproductive System
1023
4
Cardiovascular Techniques
1027
1
Endocrine System Techniques
1028
1
Orthopedic Procedures for Laboratory Animals
1029
1
Neurosurgical Techniques
1029
3
Tumor Transplantation
1032
1
Imaging Techniques
1033
1
Radiotelemetry
1034
13
References
1034
13
Control of Biohazards Associated with the Use of Experimental Animals
Thomas E. Hamm, Jr.
Introduction
1047
1
Risk Assessment
1048
1
Managing Facilities in Which Biohazards Are Used
1048
5
Other Considerations
1053
3
Responsibility for Reviewing and Approving Protocols Involving Biohazards
1056
1
Summary
1056
4
References
1056
4
Selected Zoonoses
James G. Fox
Christian E. Newcomer
Harry Rozmiarek
Introduction
1060
1
Viral Diseases
1060
14
Rickettsial Diseases
1074
2
Chlamydial Infections
1076
1
Bacterial Diseases
1077
11
Fungal Diseases
1088
1
Protozoal Diseases
1089
4
Helminth Infections
1093
5
Arthropod Infestations
1098
9
References
1098
9
Xenozoonoses: The Risk of Infection after Xenotransplantation
Marian G. Michaels
Introduction
1107
1
Lessons from Allotransplantation
1107
2
Xenotransplantation
1109
8
References
1113
4
Genetic Monitoring
John J. Sharp
Evelyn E. Sargent
Peter A. Schweitzer
Introduction
1117
1
The Need for Genetically Defined Animals
1118
1
Sources and Monitoring of Genetic Variability
1119
2
Colony Management
1121
1
Monitoring Methods
1122
4
Summary
1126
3
References
1127
2
Transgenic and Knockout Mice
Glenn M. Monasrersky
James G. Geistfeld
Introduction
1129
1
Choice of Mouse Strains for Transgenic Programs
1130
1
Production of Transgenic Mice: Animal Requirements
1131
3
Management of the Transgenic Mouse Colony
1134
9
References
1140
3
Factors That May Influence Animal Research
Neil S. Lipman
Scott E. Perkins
Introduction
1143
1
Intrinsic Considerations
1143
4
Extrinsic Considerations
1147
38
References
1165
20
Animal Models in Biomedical Research
Fred W. Quimby
What Is an Animal Model?
1185
15
The Nature of Research
1200
6
History of Animal Use in Biomedical Research
1206
22
References
1214
14
Research in Laboratory Animal and Comparative Medicine
Henry J. Baker
J. Russell Lindsey
Introduction
1228
1
The Research Process
1229
2
Research Training
1231
3
Research Resources
1234
1
Support for Research
1235
2
Summary
1237
3
References
1237
3
Laboratory Animal Behavior
Kathryn A. L. Bayne
Bonnie V. Beaver
Joy A. Mench
David B. Morton
Introduction
1240
1
Rodents
1241
4
Rabbits
1245
1
Laboratory Dogs and Cats
1246
2
Nonhuman Primates
1248
4
Farm Animals
1252
13
References
1256
9
Index
1265