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Tables of Contents for Principles of Molecular Virology
Chapter/Section Title
Page #
Page Count
Preface to the second edition
ix
Preface to the first edition
xi
Introduction
1
21
Viruses are distinct from `living' organisms
1
2
The origins of virology
3
1
Living host systems
4
2
Cell culture methods
6
2
Serological/immunological methods
8
3
Ultrastructural studies
11
5
`Molecular biology'
16
4
Further reading
20
1
Self-assessment questions
21
1
Particles
22
28
The function and formation of virus particles
22
1
Capsid symmetry and virus architecture
23
10
Enveloped viruses
33
4
Complex structures
37
5
Protein--nucleic acid interactions and genome packaging
42
4
Virus receptors -- recognition and binding
46
1
Other interactions of the virus capsid with the host cell
46
1
Summary
47
1
Further reading
47
1
Self-assessment questions
47
3
Genomes
50
47
The structure and complexity of virus genomes
50
2
Molecular genetics
52
4
Virus genetics
56
9
`Large' DNA genomes
65
3
`Small' DNA genomes
68
4
Positive-strand RNA viruses
72
3
Negative-strand RNA viruses
75
2
Segmented and multipartite virus genomes
77
4
Reverse transcription and transposition
81
10
Evolution and epidemiology
91
2
Summary
93
1
Further reading
94
1
Self-assessment questions
94
3
Replication
97
31
Overview of virus replication
97
1
Investigation of virus replication
98
4
The replication cycle
102
23
Summary
125
1
Further reading
125
1
Self-assessment questions
125
3
Expression
128
35
Expression of genetic information
128
1
Control of prokaryote gene expression
129
1
Control of expression in bacteriophage λ
130
4
Control of eukaryote gene expression
134
2
Genome coding strategies
136
10
Transcriptional control of expression
146
5
Post-transcriptional control of expression
151
8
Summary
159
1
Further reading
160
1
Self-assessment questions
160
3
Infection
163
37
Virus infections of plants
163
3
Immune responses to virus infections in animals
166
9
Virus--host interactions
175
9
The course of virus infections
184
3
Prevention and therapy of virus infection
187
3
Virus vectors and gene therapy
190
2
Chemotherapy of virus infections
192
4
Summary
196
1
Further reading
196
1
Self-assessment questions
197
3
Pathogenesis
200
39
Mechanisms of cellular injury
201
4
Viruses and immunodeficiency
205
7
Virus-related diseases
212
2
Cellular transformation by viruses
214
11
Viruses and cancer
225
3
New and emergent viruses
228
7
Summary
235
1
Further reading
235
1
Self-assessment questions
236
3
Novel infectious agents: genomes without viruses, viruses without genomes
239
20
Satellites and viroids
239
4
Prions
243
13
Summary
256
1
Further reading
256
1
Self-assessment questions
256
3
Appendix 1 Classification of subcellular infectious agents
259
9
Appendix 2 Glossary and abbreviations
268
12
Appendix 3 Answers to self-assessment questions
280
18
Index
298