This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.

Product Description: The introduction of chlorpromazine in 1953, and haloperidol in 1958, into clinical practice dramatically altered the therapy of schizophrenic patients. Although representing by no means a cure for this severe psychiatric ill­ ness, it allowed, for the first time, to adequately control the severe hallu­ cinations and delusional beliefs which prevent these patients from leading a more or less independent life...read more

Product Description: New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease...read more

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Product Description: This text presents a broad-based review of the contemporary field of drugs for schizophrenia and is intended for graduate and postgraduate students and mental health professionals. It consists of 34 chapters by well-known experts in the field addressing basic mechanisms in the pathophysiology of schizophrenia, neuropharmacology, experimental strategies, atypical antipsychotics, and other clinical issue...read more (view table of contents, read Amazon.com's description)

Discusses research findings, clinical procedures, and theoretical bases for the application of orthomolecular principles to cases of schizophrenia, alcoholism, and drug addiction where perceptual dysfunction and chemical-nutritive brain imbalances are indicated. Bibliogs