Subtilisin is the most extensively studied model system for protein engineering. The primary motivating factor for the interest in subtilisin is the commercial utility of this class of proteases. The subtilisin symposium was the first international meeting to bring together a large number of groups that have focused on the subtilisins and the subtilases-the protein superfamily of subtilisin-like enzymes. The results presented at the symposium are in this way a unique compendium of a broad spectrum of work largely focused on harnessing the potential of site-directed mutagenesis to understand and deliberately alter the function of these enzymes toward a desired end. This sort of protein engineering has been extremely successful in subtilisin, with many such "engineered" enzymes now widely used in commer­ cial enterprises. In this regard the experience derived from subtilisin does represent practical protein engineering. It is becoming clear that subtilisin represents a larger class of enzymes, the subtilases, that include many of the human pro hormone-converting enzymes. As international collabo­ rative efforts to sequence entire genomes continue, we can reasonably expect that additional members of the subtilase class will be encountered. Whenever interest in a member of this class of enzyme arises, the work on subtilisin will serve as a guide to the analysis for what in bacillus, fungi, and industry is an everyday workhorse enzyme.

Based on a symposium held November 1988, in King of Prussia, Penn. Among the topics: structural analysis of proteins, protein folding and stability, receptor design and regulation, guanine nucleotide binding protein family, modeling and structure prediction in macromolecules, protein engineering and

Product Description: One ofthe major drivers in biological research is the establishment ofstructures and functions of the 50,000 or so proteins in our bodies. Each has a characteristic- dimensional structure, highly "ordered" yet "disordered"! This structure is essential for a protein's function and, significantly, it must be sustained in the competitive and complex environment of the living cell...read more (view table of contents, read Amazon.com's description)

Product Description: Highlights the diversity of approaches used in understanding the function of proteins and how this understanding is applied to improving protein design for biotechnology applications. Reports on the status of current research into the interactions underlying protein stability...read more

Product Description: Lipases are of high practical relevance. They exhibit activity only at the water-lipid interphase and can thus be utilized for various industrial applications such as detergents and chiral synthesis. Up to now, however, progress in industrial use has been hampered by the lack of fundamental knowledge about lipase structure and function...read more

Product Description: Host-Guest Molecular Interactions: From Chemistry to Biology Chairman: I.O. Sutherland 1991 Host - guest molecular interactions lead to the formation of molecular assemblies containing two or more species. It has long been recognized that such supramolecular' association is of fundamental importance in biological processes, but it is only recently that chemists have begun to design and synthesize novel host molecules...read more (view table of contents, read Amazon.com's description)

Product Description: Quantitative structure-activity relationships constitute a subject which has seen enormous growth in the past decade. Techniques which have been developed and used widely outside of medicinal chemistry are now used by those working with QSAR...read more

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Product Description: Protein folding, the self-directed transition from disorganized chains to highly ordered and functional biological structures, is of increasing practical concern for the biotechnology industry and for research on DNA sequences. This volume, based on an AAAS Annual Meeting seminar, emphasizes new interactions between theory and experiment and looks closely at the process of tailoring proteins and their fragments for the testing of folding hypotheses...read more

Product Description: There are very few parts of biology that remain free from the influence of Genetic Engineering developed in the early 1970s. Disciplines as wide apart as Brewing, Forensic Science and Population Genetics have all been affected in some way...read more

Product Description: Proceedings of the Tenth Course of the International School of Pure and Applied Biostructure (Erice, Italy, June 1989). Knowledge of protein structure and of design and manufacture methods has made it possible to produce proteins of any desired sequence, but progress is limited by inability to pred...read more

Product Description: Outstanding characteristics Camera ready Marketing arguments 1. Worldwide leading experts present aspects of current research. 2. The contributions deal with methods and theoretical concepts as well as the design of industrial enzymes, antibodies and protease inhibitors.

Product Description: Protein engineering has had considerable impact on basic and applied research in biochemistry and molecular biology. It is already in use as a tool in molecular biology, but it is beginning to strongly influence the planning of experiments in biology everywhere, and, with even fur­ ther-reaching consequences, the appointment politics in research in­ stitutions and industries...read more

Product Description: Methods in Protein Sequence Analysis -1986 brings together reports of the most recent methodology available to protein chemists for studying the molecular detail of proteins. The papers in this volume constitute the proceedings of the Sixth International Conference on Methods in Protein Sequence Analysis, which was held at the University of Washington in Seattle, Washington on August 17-21, 1986...read more