Product Description: Genetics of Complex Disease examines how the identification of genetic variations that increase or reduce the risk of common, genetically complex, diseases can be used to improve our understanding of the pathology of many common diseases; enable better patient management and care; and help with differential diagnosis...read more

Product Description: This book shows how the mitochondrial genome is transmitted, segregated and inherited. Opens by describing mtDNA mutations and deletions and showing how these impact the offspring’s well-being, covers mtDNA transmission and discusses transmittal and adaptation.

Product Description: The sequencing of the human genome has brought human genetics into a new era of study resulting in the generation of an explosive amount of information. Application of genomic, proteomic, and bioinformatics technologies to the study of human genetics has made it possible for human genetic diseases to be studied on an unprecedented scale, both in silico and in the wet lab...read more

Second Edition features the latest tools for uncovering the genetic basis of human disease The "Second Edition" of this landmark publication brings together a team of leading experts in the field to thoroughly update the publication. Readers will discover the tremendous advances made in human genetics in the seven years that have elapsed since the "First Edition." Once again, the editors have assembled a comprehensive introduction to the strategies, designs, and methods of analysis for the discovery of genes in common and genetically complex traits. The growing social, legal, and ethical issues surrounding the field are thoroughly examined as well. Rather than focusing on technical details or particular methodologies, the editors take a broader approach that emphasizes concepts and experimental design. Readers familiar with the "First Edition" will find new and cutting-edge material incorporated into the text: Updated presentations of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environment interactions A completely rewritten and updated chapter on determining genetic components of disease New chapters covering molecular genomic approaches such as microarray and SAGE analyses using single nucleotide polymorphism (SNP) and cDNA expression data, as well as quantitative trait loci (QTL) mapping The editors, two of the world's leading genetic epidemiologists, have ensured that each chapter adheres to a consistent and high standard. Each one includes all-new discussion questions and practical examples. Chapter summaries highlight key points, and a list of references for each chapter opens the door to further investigation of specific topics. Molecular biologists, human geneticists, genetic epidemiologists, and clinical and pharmaceutical researchers will find the "Second Edition" a helpful guide to understanding the genetic basis of human disease, with its new tools for detecting risk factors and discovering treatment strategies.

With the explosion of new information from the Human Genome Project and new disease genes being identified at an extraordinary rate by laboratories around the world, the need for a scientifically sound a pedagogically refined text in Human Molecular Genetics has grown. This new text offers students and readers an extensive, up-to-date treatment of the genetic principles and fundamental molecular mechanisms that govern human inherited diseases. More than a catalogue of disease-related genes, this new text explains the interaction of genes and their products; the consequences of these mechanisms on disease states in major organ systems such as muscle, the nervous system, and the eye; and cancer and mitochondrial disorders. Praised by numerous reviewers for its timeliness and accuracy, An Introduction to Human Molecular Genetics is an ideal text for advanced undergraduate, early graduate and basic medical school courses in human genetics. The book's lucked style and compelling coverage make it essential reading for all those who seek a better understanding of the fast moving field of Human Molecular Genetics. Engaging writing style and numerous illustrations making complex concepts accessible to all students. Chapter outlines, lists of key terms, extensive summaries of key concepts and review questions are provided for each chapter. Up-to-the-minute research and numerous references cited throughout. From the Human Genetics Files' sections in each chapter present historical and innovative applications and contributions of Human Molecular Genetics (like the use of DNA analysis to identify the remains of the Russian Imperial family). Full-colour insert illustrates the latest cytogenetic imaging techniques (FISH, SKY). The text will be complemented with a web site (starting 1/1/2000) that will provide new material divided into 'Updates' and 'Breakthroughs'.

This accurate, concise, and clearly written text has been revised to include the numerous genes and relationships that have been identified since its first printing in 1994.

Product Description: Medical Genetics is the clearest and most concise text on the subject, providing state-of-the-art coverage of clinically relevant molecular genetics. Lynn B. Jorde, PhD; John C. Carey, MD; and Michael J. Bamshad, MD integrate recent developments with clinical practice and emphasize the central principles of genetics and their clinical applications...read more

Product Description: A fast moving research area where there is an ever-expanding interest, and which impacts upon a wide variety of genetic diseases. Important introductory section which considers the merits of methods employed in these studies, and examines factors which influence study design...read more (view table of contents, read Amazon.com's description)

Product Description: Analysis of Multifactorial Diseases examines the evidence of genetic factors that increase susceptibility to a range of complex diseases and describes the approaches taken to identify these genes. It reviews the successes and failures and examines whether there are any general conclusions to be drawn from this current range of approaches...read more