Presents the results of a meeting of neurologists and pediatricians held in Goslar, West Germany in November 1986 in order to discuss the state of the art in the treatment of epilepsy. Contributors discuss the basic mechanisms and classification of epilepsy, diagnosis, drug treatment, new antiepileptic drugs under development, and a review of the comprehensive care of patients with epilepsy. Specific topics covered include synaptic transmission and its relation to epilepsy, seizure types and epileptic syndromes in children, EEG in epilepsy, neuroimaging in epilepsy, differential diagnosis of epilepsy, monitoring drug treatment, side effects, and comprehensive epilepsy service.

The pharmacological fight against epilepsy began many centuries ago when Hippocrates discovered that the cause of epilepsy is natural, as opposed to supernatural and, as a consequence, must be treated with a natural remedy. Even though science has significantly progressed since that era, the challenge to find remedies for epilepsy is ever present. The aim of this particular volume is to offer an up-to-date review of the most recent advances in antiepileptic drug development, considered from various viewpoints: (i) general, by taking into account the size of refractory epilepsy and its related problems; (ii) experimental, by exploring the mechanisms of epileptogenesis and the possiblility of influencing it through drugs, and (iii) clinical, by describing the results obtained with compounds currently at an advanced stage of testing.

Product Description: This book explores, for the first time, the clinical relevance of kindling. A number of conditions including epilepsy, and manic depressive psychosis and additional states in which a process similar to kindling may be of importance are highlighted...read more

Product Description: Drug-resistant epilepsy with negative MRI is frequently seen in patients considered for epilepsy surgery; however, clinical evaluation and surgical treatment is very complex and challenging. Advanced imaging techniques are needed to detect the location of the epileptogenic zone...read more

Product Description: Have you ever made a wish? Well imagine meeting a very special creature who tells you that he can help you get that wish? That is exactly what happens to a young girl named Sarah in Sarah's Special Wish.

Product Description: Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks builds on earlier works focusing on the clinical problem of sudden unexpected death in epilepsy (SUDEP). This book presents a methodology for identifying and classifying clusters of risks that lead to SUDEP...read more

Product Description: Patients with brain tumor-related epilepsy (BTRE) suffer from two serious pathologies simultaneously – a brain tumor and a secondary form of epilepsy.  Although there has been remarkable progress in BTRE research in recent years, it remains an on-going challenge for clinicians and continues to stimulate much debate in the scientific community...read more

Product Description: Epilepsy care traditionally focuses on seizures, yet for most epilepsy sufferers, other interictal factors such as mood, cognitive abilities, and treatment adverse effects most influence how they feel and function day to day.Epilepsy and the Interictal State is a practical and comprehensive text that covers quality of life issues, cognition and therapy, adverse effects of epilepsy treatments, mood state and psychiatric co-morbidity and general health aspects of epilepsy...read more

The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7‐9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.

Product Description: While tonic-clonic seizures are the most commonly recognized, approximately 60% of patients with epilepsy actually have partial-onset seizures, with one side of the brain being affected. While clinicians regularly see patients with partial-onset seizures, in both the community or office setting, it is often challenging to determine what the type of epilepsy is being experienced and which treatment should be administered...read more

Product Description: Epilepsy is a complicated neurological condition with variable manifestations, numerous etiologies, and a diverse range of treatments. It is a chronic disease that, in many cases, can be controlled. However, treatment requires accurate clinical evaluation to allow intelligent treatment choices...read more

Product Description: The idea for this book has evolved from our desire to present a conceptual approach to the study of neurotransmitters in epilepsy. Such an approach requires an understanding of the function of neurotransmitter systems in various experimental models of epilep­ sy...read more