Product Description: Studies on the elucidation of structure-function relationships in biochemistry and molecular biology started a few decades ago and represent an area of continuing interest. The celebration of the 75th birthday of Alessandro Rossi Fanelli, who has made signi- cant contributions in this field, prompted the organization of a Symposium on 'Structure-Function Relationships in Biochemical Systems' with the aim of bringing together Rossi Fanelli's students and many of the scientists who have been connected with the Institute of Biological Chemistry in Rome...read more

Product Description: This handbook, now in a new, second edition, is an essential resource for scientists with an interest in the role of glycosyltransferases and related genes involved in the biosynthesis of glycoproteins, glycolipids, and proteoglycans...read more

Proceedings of the summer 1996 workshop, presenting research in interpretations of three-dimensional structure and regulatory elements of genes controlling for tissue-specific expression of particular enzymes. Subjects include human corneal and lens aldehyde dehydrogenases, regulation of rat ALDH-3

Product Description: Proceedings of the NATO Advanced Research Workshop, Reisensburg/Ulm, Donau, Germany, June 16-22, 1985

Product Description: The Fifth International Meeting on Cholinesterases convened in Madras, India, in September of 1994. The long and rich history and culture of India provided an excellent setting for the meeting. More than 120 delegates from Asia, Australia, Europe and North America heard 54 oral presentations and viewed 54 posters on current research on enzymes of the cholinesterase family...read more

Product Description: Since the inception of these meetings in 1982, they have always been a satellite of the International Society for Biomedical Research on Alcoholism meeting. At our 1992 meeting in Dublin we learned that the next ISBRA meeting would be held in Brisbane, of all our previous meetings, I was very concerned Australia...read more

Product Description: The increased interest in multiple forms of enzymes that began with the application of new methods of fractionation to preparations of enzymes and other proteins some 25 years ago led quickly to an appreciation that the existence of enzymes in multiple forms, or isoenzymes, is a general phenomenon...read more

Product Description: The Sixth International Meeting on Cholinesterases and Related Proteins, Choli­ nesterases '98, was organized by Palmer Taylor and his associates at the University of California-San Diego and convened in La Jolla, California, USA, in March of 1998...read more

Product Description: In September 1998 experts from 19 countries came together for an interdisciplinary discussion of the function of animal peroxidases, a family of enzymes embracing myeloperoxidase, eosinophil peroxidase, thyroid peroxidase and lactoperoxidase...read more

Product Description: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of two volumes covering protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles...read more

Product Description: Proceedings of the First International Workshop held in Mar de Plata, Argentina, August 26-30, 1996

The VIIth International Conference on Aspartic Proteinases was held in Banff, Alberta, Canada, from October 22 to 27, 1996. The venue was the Banff Centre in the Canadian Rockies, a setting well known worldwide for the scenic beauty and mountain grandeur. It was perhaps presumptuous of the organizers to call this the seventh Aspartic Proteinase Conference but it was felt that the meeting in 1982, organized by Tom Blundell and John Kay, was of an international stature and covered topics sufficiently broad to constitute a conference. Thus, there is a discontinuity in that the Gifu Conference organized by Prof. Kenji Takahashi was the fifth International Conference on Aspartic Proteinases. Officially, there has not been a sixth Conference and if there is confusion, it is the result of my desire to recognize the importance of the London meeting. Banffhosted 106 scientists from 14 different countries. There were 26 invited speak­ ers among the 44 oral presentations of the 7 main sessions. In addition, there were 53 con­ tributed poster presentations that spanned the whole range of interest in aspartic proteinases.

Product Description: Enzymes are bio-catalysts which effect transformation of substrates to products with high specificity. The usage of enzymes in domestic and industrial applications is well known and has been well documented since the early history of civilization...read more

This volume contains up-to-date information on aldehyde dehydrogenase, alcohol dehydrogenase, short- and medium-chain dehydrogenase, and reductases. Sixty-nine contributions provide a wide variety of information on enzymology, molecular biology, and metabolic aspects of these carbonyl metabolizing oxido-reductases. Much new information is provided, including previously unreported three-dimensional structures of enzymes and new aspects of gene regulation, along with sequence alignments, metabolism and enzyme mechanisms.

Product Description: The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific organophosphorus (OP) insecticides...read more (view table of contents, read Amazon.com's description)

Product Description: The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific organophosphorus (OP) insecticides...read more

Product Description: Proceedings of the First International Workshop held in Mar de Plata, Argentina, August 26-30, 1996

Product Description: The Sixth International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism was held outside of Dublin, Ireland at the end of June, 1992. Prof. Keith Tipton, Chairman of the Biochemistry Department at Trinity College, kindly agreed to host the meeting...read more

This book is concerned with a quantitative analysis of dynamic behavior of various enzymatic reaction systems by computer simulation. The authors and coworkers have been engaged in cooperative research since 1975, seeking to clarify the catalytic and regulatory characteristics of enzymatic reactions in vivo and control mechanisms suitable for enzyme technology. Rather than "enzyme kinetics" generally known in enzymol· ogy, this research has employed an approach called "enzyme dynamics" which concentrates on the exact schematic representation of an actual reac­ tion mechanism, derivation of rate equation on the basis of the scheme, and computer simulation of its dynamic behavior (numerical solution of the rate equation and explanation of kinetic and regulatory properties of the enzymatic reaction). A rate equation representing the behavior of enzymatic reactions is gen­ erally expressed by a set of nonlinear differential equations. The analytic solution of rate equations is therefore impossible in general, making it necessary to introduce some approximations in order to analyze the exper· imental data in enzyme kinetics. For example, under an assumption of excess substrate against enzyme in a closed system, we commonly use the linear approximation for the early period of reaction, the quasi-steady­ state approximation based on putative maintenance of steady state in en­ zyme species, and the rapid-equilibrium approximation assuming instantane­ ous equilibration in complex formation and between complexes. The kinetic characteristics obtained by these approximations do not always reflect the dynamic behavior of actual enzymatic reactions.