Product Description: Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced...read more

Product Description: Typee: A Peep at Polynesian Life is the first book by American writer Herman Melville, published first in London, then New York, in 1846. Considered a classic in travel and adventure literature, the narrative is based on the author's actual experiences as a captive on the island Nuku Hiva in the South Pacific Marquesas Islands in 1842, but is liberally supplemented with imaginative reconstruction and adaptation of material from other books...read more

Product Description: Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation...read more

Product Description: Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing new treatments...read more

Product Description: Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance...read more

Product Description: During endocytosis, extracellular molecules and plasma membrane components are selectively internalized by cells. This fundamental process of "cellular ingestion" is required for diverse activities such as nutrient uptake, cell adhesion and migration, signal transduction, cytokinesis, neurotransmission, and antigen presentation...read more

Product Description: This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.

Product Description: We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses...read more

Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

Product Description: Over the last decades cell biology and biological chemistryhave increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling...read more

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Product Description: Regucalcin is a protein which is highly differentiated due to increased conservation of the regucalcin genes throughout evolution in vertebrates. Regucalcin plays a multifunctional role in cellular regulation, including an inhibitory role in protein kinases, protein phosphatases, NO synthase, nuclear DNA and RNA synthesis...read more

Product Description: Calcium ions play a critical role in signaling in a wide variety of cells and tissues, including muscle, immune cells, neurons, the liver, and oocytes. They can enter the cytoplasm from the extracellular environment or from intracellular stores and control the activity of numerous enzymes, other signaling molecules, transcription factors, and cytoskeletal components...read more

Focussing on the molecular mechanisms that govern mast cell and basophil cell biology and function, this book also provides a comprehensive summary of the field of signal transduction, giving insights into areas that have therapeutic potential. It gives detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide readers with an up-to-date account of a topic whose rapid progress makes conventional information gathering difficult.

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Product Description: Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology.  The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms...read more

Product Description: Understand how the intricacies of multispecies community life are related to human oral health. Explores the immense opportunities presented by readily accessible, genetically tractable, genome-sequenced oral species that naturally form multispecies communities...read more