Product Description: Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities...read more

Product Description: A cell cycle is an ordered and highly controlled set of events that leads to cell growth and proliferation. Cell cycle progression is driven by changes in the substrate specificity and subcellular localisation of cyclin-dependent kinases (Cdks), which in turn are modulated by a collection of cyclins, Cdk-activating and Cdk-inhibiting kinases, and Cdk inhibitors (CDKIs)...read more

Product Description: This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field...read more

Product Description: A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners...read more

Product Description: This volume introduces some basic mathematical models for cell cycle, proliferation, cancer, and cancer therapy. Chapter 1 gives an overview of the modeling of the cell division cycle. Chapter 2 describes how tumor secretes growth factors to form new blood vessels in its vicinity, which provide it with nutrients it needs in order to grow...read more

The groups of specialized cells that make up the various human tissues depend on an intricate communication network to regulate gene expression that in turn mediates growth, cell-type specific function, division, and programmed cell death. This network consists of extracellular signals interacting with the receptors of individual cells and determining the fate of each. Since this regulatory system plays a critical role in complex tissue, aberrations or malfunctions often accompany the onset and progression of cancer. Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition provides a solid basis for understanding cell cycle and growth control as it relates to biological regulation, with a special emphasis on examining these processes in the context of cancer. Newly updated with the latest significant advances, this Second Edition features: * Cutting-edge applications in clinical diagnostics and therapeutics * Focus on mechanisms mediating the control of proliferation * Numerous clear illustrations * Extensive bibliography * Well-recognized, expert chapter authors * Video clips on accompanying Web site showing cell cycle control Cell Cycle and Growth Control, Second Edition offers both an introduction to important concepts and detailed discussion of regulatory mechanisms at the cellular, biochemical, genetic, and molecular levels. The only book to comprehensively cover both the foundations and cutting-edge advances in understanding cell cycle and growth control, this text also contains an expert perspective on innovative strategies for cancer treatment, making it a vital companion for researcher and clinician alike.

Product Description: In this contribution, several specialists describe the current knowledge on the molecular networks that regulate cell cycle progression, with an emphasis on the G1 phase of the cell cycle. The first part of Regulation of G1 Phase Progression is concerned with the individual molecules that form the network, including cyclins, cyclin-dependent kinases, inhibitors of these kinases and retinoblastoma and p53...read more (view table of contents, read Amazon.com's description)

Product Description: This volume deals with the most advanced areas of reactivation of the cell cycle in terminally differentiated cells. Terminally differentiated cells have long been regarded as irreversibly unable to proliferate. However, this view is being overturned, with great implications for both biological knowledge and potential therapeutic applications...read more

Product Description: Cell Cycle Checkpoints and Cancer is about mechanisms of normal and cancer cell cycling, checkpoint control, and the link of mitogenic signalling and cell cycle machinery. Checkpoint mechanisms from yeast to man are addressed to allow a comprehensive understanding of the cell cycle...read more

Product Description: The nucleus guides the life processes of the cell by directing cellular reproduction, differentiation during development, and metabolism. The study of the structure and function of the nucleus along with its genetic material serves as the foundation for the science of genetics...read more (view table of contents, read Amazon.com's description)

Product Description: Recent advances in our understanding of the biochemical and molecular mechanisms of cell growth and control have led to sensational breakthroughs in the diagnosis and treatment of proliferative and neoplastic diseases. As a consequence, cell growth and regulation has become a subject of vital interest to basic researchers and clinicians alike...read more (view table of contents, read Amazon.com's description)

Product Description: Addressing the regulation of the eukaryotic cell cycle, this book brings together experts to cover all aspects of the field, clearly and unambiguously, delineating what is commonly accepted in the field from the problems that remain unsolved...read more (view table of contents, read Amazon.com's description)

Product Description: Natl. Research Council, Ottawa, Canada. Summary of current knowledge on calcium. For professionals. (view table of contents, read Amazon.com's description)

Product Description: To understand cancer we must know how Ca2+ drives cell cycles and how and why cells lose Ca2+ control while climbing the steps to cancer. This book presents a much needed and concise, but wide-ranging overview of what we know about the several different roles of Ca2+ in starting, and subsequently driving, the major cell cycle transitions...read more

Product Description: There is growing evidence that the cell nucleus like the cytoplasm is organized into different functional domains. The best-characterized intranuclear domain is the Nucleolus. This review presents and discusses recent progress in the understanding of nucleolar architecture and its relationship to nucleolar functions...read more

Product Description: Research into the cell cycle has progressed rapidly in recent years on many fronts, using many different organisms, and is one of the most exciting areas of contemporary biology. What makes a cell begin the complicated process of cell division? How does it stop? What happens when things go wrong? The use of developing technologies has revealed the extraordinary degree to which cell cycle control mechanisms have been conserved through eukaryotic evolution...read more

Product Description: The second edition of Calcium in Cell Cycles and Cancer presents a unique overview of calcium's roles in the several stages of cell cycles initiated by signals from "velcroceptors" and other kinds of growth-factor receptors. This book integrates the actions of calcium and its partner, cyclic AMP, with those of the growing family of newly discovered, stage-specific, cyclin-dependent protein kinases of the "cell cycle engine...read more (view table of contents, read Amazon.com's description)

How the new vision of normal cellular reproduction emerged. It is a portrayal of the molecular logic of the cell: how the cell engine induces DNA replication and chromosome replication; how the integrity of genetic information is preserved; and how cell size and environmental signals regulate the cycle of growth and division.

Product Description: A mathematician who has taken the romantic decision to devote himself to biology will doubtlessly look upon cell kinetics as the most simple and natural field of application for his knowledge and skills. Indeed, the thesaurus he is to master is not so complicated as, say, in molecular biology, the structural elements of the system, i...read more