Product Description: Nullius in verba. . . Truth will be tested not by words. Horace (Epistles) Few read introductions except for book reviewers, who want to take a shortcut and avoid reading the book itself. However, tradition requires that the preface make public why the book was written at all (this is not supposed to include powerful reasons such as augmenting the ego of the editor and authors)...read more

Product Description: Covers the synthesis of promising new analogues. Studies structure-activity relationships of anthracycline antibiotics. Investigates new approaches to improving properties for anthracyclines by using different drug-delivery and tumor-targeting systems...read more

Product Description: The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons :o/hy such an initiative was considered necessary...read more

Product Description: Describes cutting edge approaches in the development of anticancer agents for chemotherapy. These new and interdisciplinary approaches are aimed at the development of tumor specific anticancer agents while increasing the potency against drug-resistant tumors...read more

Product Description: Book by Ottenbrite, Raphael M., Butler, George

Product Description: Experienced cancer researchers from pharmaceutical companies, government laboratories, and academia comprehensively review and describe the arduous process of cancer drug discovery and approval. They focus on using preclinical in vivo and in vitro methods to identify molecules of interest, detailing the targets and criteria for success in each type of testing and defining the value of the information obtained from the various tests...read more

Product Description: With the publication of these proceedings from the Second Drug Discovery and Development Symposium, this forum has become the main mechanism for bringing together the principal groups involved in both discovering and developing new approaches to the treatment of cancer...read more

Product Description: Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer-related deaths per year...read more

Product Description: Affords researchers ready access to a vast body of information on identifying and isolating natural anticancer agents… The authors open this valuable text/reference with an in-depth exploration of the vast potential of plant, animal, microorganism constituents as sources for new and effective anticancer, antiviral drugs...read more (view table of contents, read Amazon.com's description)

Product Description: Much progress has been made in the treatment of emesis caused by antineoplastic therapy, and particularly chemotherapy. However, some aspects remain controversial and the subject of continued research. This completely updated comprehensive manual on antiemetics covers a wide range of clinically relevant topics, providing the reader with a good source of easy consultation, and giving an overall picture of the state of the art and some clues for future development...read more

Antifolates are an important class of anticancer drugs originally developed as anti leu kemic agents, but now used, usually in combination with other drugs, for the treatment of a wide range of tumors, notably carcinomas of the head and neck, breast, germ cell tumors, non-Hodgkin's lymphoma, acute lymphoblastic leukemia, and osteogenic sar comas. 5-Fluorouracil and its prodrugs also target, in part, the folate-dependent enzyme, thymidylate synthase. Furthermore, folate supplementation in the form of leucovorin, modulates 5-fluororuacil activity. 5-Fluorouracil is widely used in the treatment of colorectal and gastric cancer and in combination for other solid tumors such as breast and head and neck cancers. Ongoing clinical trials with the newer antifolates suggest that the range of solid tumors where these agents will be of use may broaden further. Half a century ago, interesting scientific and clinical discoveries suggested that folie acid was a vitamin involved in vital cellular metabolic processes. The folate analogs, aminopterin and methotrexate, were synthesized by the American Cyanamid Company in an attempt to interfere with these processes and were shown to have anticancer activity by Farber and his colleagues. Hence, the principle of antimetabolite therapy for the treatment of cancer was established. Biomedical research over the following years led to a deeper understanding of the complex biochemical pharmacology of folates and antifolates. Selective antimicrobial agents were discovered, but more tumor-selective anticancer agents did not immediately emerge.

Product Description: A multidisciplinary approach for understanding the status of antitumor drug research and the future development of improved drugs. Provides a broad set of perspectives on the problem of antitumor drug development from tumor cell biology and drug screening to drug design and chemistry...read more

Product Description: 1983, hardcover edition, volume 419 in a series, New York Academy of Sciences, NY, 273 pages. Very technical. Figures / graphs / b&w photos. Presents a series of technical essays written by informed scholars in the field.

Discusses the use of antioxidants to reduce the risk of cancer, help prevent recurrences, and decrease the side effects of conventional treatments, and details which food supplements are essential for an antioxidant program.

Product Description: Hardback book titled ANTITUMOR COMPOUNDS OF NATURAL ORIGIN.

Product Description: Book by Aszalos, Adorjan

Product Description: This volume reviews the experimental data on drug-radiation interactions. Special emphasis is placed on clinically-useful antitumor drugs. Particular reference is made to appropriate timing, concentration and sequencing of drug-radiation combinations...read more