Reflecting more than a decade’s worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism and relevance used in toxicology. Individual chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory “course” along with guidance to the literature for more detailed understanding. The book goes on to make the case for a range of species not commonly used for safety assessment studies but which may provide useful alternative models for some specific endpoints. The chapter authors discuss special considerations regarding the evaluation and interpretation of the clinical pathology of the eight major model species as well as how to select a model species and how to extrapolate the results to humans. They detail potential pitfalls and situations that cause either human or model to be significantly more sensitive than the other or totally irrelevant to each other. The book concludes with an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized, and an appendix that provides a quick guide to commercial sources of laboratory animals.

Product Description: This multi-volume set comprises all the handbooks in Shayne Gad's comprehensive and authoritative Pharmaceutical Development Series. A unique resource for researchers, toxicologists, and clinicians, this collection includes: Drug Discovery Handbook, Handbook of Pharmaceutical Biotechnology, Preclinical Development Handbook: ADME and Biopharmaceutical Properties, Preclinical Development Handbook: Toxicology, Pharmaceutical Manufacturing Handbook: Production and Processes, Pharmaceutical Manufacturing Handbook: Regulations and Quality, Clinical Trials Handbook, and Development of Therapeutic Agents Handbook...read more

Product Description: Pharmaceutical Manufacturing Handbook covers a range of topics to help professionals better understand the methods used in the pharmaceutical manufacturing, pharmaceutical engineering, and process engineering fields. It covers many aspects, such as the building of a facility, to the various dosage and delivery forms available, and finally to the principles of validation...read more

Product Description: Preclinical Development Handbook, 2-Volume Set

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