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Tables of Contents for Development of Novel Antimicrobial Agents
Chapter/Section Title
Page #
Page Count
List of Contributors
vii
 
Preface
x
 
Section 1 - The Problem of Antimicrobial Resistance
Are We on the Threshold of the Post-Antibiotic Era?
1
16
Karl Lohner
Erich Staudegger
Origins and Evolution of Antibiotic and Multiple Antibiotic Resistance in Bacteria
17
14
Ruth M. Hall
Christina M. Collis
Antimicrobial Peptide Resistance Mechanisms in Bacteria
31
14
Arden Aspedon
Eduardo A. Groisman
Section 2 - Microbial Genomics: Novel Targets and Vaccines
Genetic Engineering of Novel Macrolide Antibiotics
45
16
Robert McDaniel
Leonard Katz
Granulysin, A Novel Mediator of Antimicrobial Activity of Cytolytic T-cells
61
10
Steffen Stenger
Alan M. Krensky
Robert L. Modlin
The Immunostimulatory Properties of Bacterial DNA
71
10
David S. Pisetsky
Bacteria-Mediated DNA Transfer for Gene Therapy and Genetic Vaccination
81
10
Siegfried Weiss
Trinad Chakraborty
Potential Mucosal Adjuvants For Human Use
91
16
Mari Ohmura
Raymond J. Jackson
Yoshifumi Takeda
Jerry R. McGhee
Attenuated Bacteria as Delivery Vehicles for Helicobacter pylori Vaccines
107
16
Thomas G. Blanchard
Steven J. Czinn
Development of an Adhesin Vaccine to Prevent Urinary Tract Infection
123
16
Matthew A. Mulvey
Scott J. Hultgren
Solomon Langermann
Section 3 - Innate Immunity: Antimicrobial Peptides
Antimicrobial Peptides in Innate Immunity
139
10
Tomas Ganz
Robert I. Lehrer
The Role of Membrane Lipid Composition in Cell Targeting of Antimicrobial Peptides
149
18
Karl Lohner
Molecular Mechanisms of Membrane Perturbation by Antimicrobial Peptides
167
16
Katsumi Matsuzaki
Molecular Mechanism of Cell Selectivity by Linear Amphipatic α-helical and Diasteriomeric Antimicrobial Peptides
183
22
Ziv Oren
Yechiel Shai
Molecular Interactions Involved in Bactericidal Activities of Lantibiotics
205
10
Ulrike Pag
Hans-Georg Sahl
Cyclic Cystine-knot β-Stranded Antimicrobial Peptides: Occurrence, Design and Synthesis
215
26
James P. Tam
Yi-An Lu
Jin-Long Yang
Qitao Yu
Synthetic Combinatorial Libraries: An Emerging Approach Toward the Identification of Novel Antibiotics
241
20
Sylvie E. Blondelle
The Commercial Development of the Antimicrobial Peptide Pexiganan
261
10
Michael Zasloff
Appendix
271
2
Index
273