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Tables of Contents for Immunomodulation of Pancreatic Islets
Chapter/Section Title
Page #
Page Count
Foreword
xxv
 
Preface
xxvii
 
Approaches to Achieving Tolerance
1
16
Kathryn J. Wood
Strategies to Tolerance Induction
5
5
Mechanisms of Tolerance Induction
10
7
The Role of T Cells in Transplant Rejection
17
14
Lee Anne Tibbles
Andrew I. Lazarovits
The MHC Gene Products as a Target for Allorecognition
17
2
Structure of the TCR
19
1
Thymic Selection of the T Cell Repertoire
20
1
The Biochemistry of Signal Transduction
21
2
Accessory Molecules in T Cell Activation
23
2
Cytotoxic T Cells
25
1
Conclusion
26
1
Acknowledgements
26
5
Allo-and Xeno- Antibody Mediated Events of Pancreatic Islet Grafts
31
10
Leendert C. Paul
Tissue Damage by Antibodies
32
2
Antibodies in Xenogeneic Islet Cell Grafting
34
2
Diabetes-Associated Autoantibodies
36
1
Antibody-Mediated Protection of Allografted Tissues
36
1
Conclusions
37
4
Cytokines in Transplantation
41
10
Margaret J. Dallman
Cytokines Produced as a Result of Surgical Procedures and Inflammation
41
2
Cytokines Produced as a Result of the Antigen-Specific Immune Response
43
1
Cytokines and the Induction of Immunosuppression or Transplantation Tolerance
44
7
Role of Adhesion Molecules in Transplantation
51
12
Carl G. Figdor
Y. van Kooyk
Mechanisms that Regulate Leukocyte Adhesion
51
1
Adhesion Cascades
52
2
Role of Lymphocyte Adhesion Receptors In Vivo
54
3
Conclusions
57
1
Acknowledgements
57
6
Immunosuppression for Islet Transplantation
63
12
Paul F. Gores
David E. R. Sutherland
Nature of the Islet Preparation
63
1
Immunosuppression
64
1
15-Deoxyspergualin
65
1
Pilot Study of 15-Deoxyspergualin in Human Islet Transplantation
66
2
Future Strategies
68
7
Islet Transplantation to Immunoprivileged Sites
75
12
Helena P. Selawry
Anterior Chamber of the Eye: (AC)
75
1
The Check Pouch of the Hamster
76
1
The Brain
76
3
The Testis
79
4
Conclusions
83
4
Intrathymic Islet Transplants and Systemic Tolerance
87
12
George L. Mayo
Andrew M. Posselt
Louis Campos
Barbara C. Deli
Clyde F. Barker
Ali Naji
Intrathymic Islet Transplantation in Chemically Diabetic Recipients
88
4
Untrathymic Islet Transplantation in Spontaneously Diabetic BB Rats
92
1
Intrathymic Islet Xenografts (Rat to Mouse)
93
1
Systemic Tolerance Following Intrathymic Inoculation of Lymphohematopoietic Cells
93
6
Immunomodulation of Pancreatic Islets by Culture
99
12
Pierre Y. Benhamou
Yoko Mullen
Islet Viability Under Different Culture Conditions
99
2
Immunomodulating Effects of Various Culture Conditions
101
2
Mechanisms Involved in Islet Immunomodulation by Various Culture Methods
103
3
Conclusion
106
5
Immunomodulation by Ultra- Violet B Irradiation
111
18
Mark A. Hardy
Eleni S. Athan
Elliot R. Goodman
Soji F. Oluwole
Induction of Unresponsiveness by Direct UV-B Irradiation of Islet Cells
111
2
Induction of Specific Unresponsiveness to Islet Allografts by UV-B Irradiated DST
113
1
Induction of Tolerance to Islet Allografts by Recipient Pretreatment with UV-B Bone Marrow Transplantation
114
1
Induction of the Tolerance to Islet Allografts by Recipient Pretreatment with Intrathymic UV-B Allogenic Spleen Cells, Resting T-Cells or Soluble Peptides
115
1
Underlying Mechanisms of Effect of UV-B Irradiation on the Immune System
116
7
Acknowledgements
123
6
Antibodies Directed to MHC Determinants For Transplantation
129
12
Denise Faustman
Inactivation or Destruction of Host's T Cells with Antibody
130
1
Eliminate Passenger Lymphocytes from the Donor Cells Prior to Transplantation
131
2
Camouflage, Mask or Genetically Eliminate Donor Transplant Antigents Prior to Transplantation
133
3
Summary
136
5
Tolerance and the Costimulatory Pathway
141
12
David M. Harlan
Carl H. June
Definitions and Background
141
1
T Cell Activation
142
1
Identification of CD28 as a Costimulatory Receptor of T Cells
143
1
Effects of CD28 on T Lymphocytes in Vitro
144
1
Identification of B7 as a Stimulatory Ligand for the CD28 Activation Pathway
144
1
Both CD28 and B7 Belong to Families of Related Receptors
144
1
In Vivo Evidence Supporting the Role of the Costimulatory Molecule in Immune Responses
145
1
Blocking the Costimulatory Pathway to Induce Graft Tolerance
146
1
Discordant Xenografts
147
1
Concluding Remarks
148
1
Acknowledgements
148
5
Oral Tolerance
153
8
Mohamed H. Sayegh
Howard L. Weiner
Charles B. Carpenter
Animal Models
153
3
Oral Tolerance in Humans
156
1
Future Directions
157
4
Immunomodulation of Islet Transplantation: Future Prospects
161
12
Francis T. Thomas
Index
173