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Tables of Contents for Platinum-Based Drugs in Cancer Therapy
Chapter/Section Title
Page #
Page Count
Preface
v
Contributors
xi
Part I: Platinum Chemistry
The Chemistry of Cisplatin in Aqueous Solution
3
34
Susan J. Berners-Price
Trevor G. Appleton
Chemistry and Structural Biology of 1,2-Interstrand Adducts of Cisplatin
37
26
Viktor Brabec
Transplatin-Modified Oligonucleotides as Potential Antitumor Drugs
63
26
Marc Leng
Annie Schwartz
Marie-Josephe Giraud-Panis
Part II: Platinum Biochemistry
Cisplatin Accumulation
89
26
Paul A. Andrews
Cisplatin Resistance in Ovarian Cancer: Mismatch Repair and Engagement of Apoptosis
115
14
Robert Brown
DNA Adduct Tolerance and Bypass
129
20
Stephen G. Chaney
Alexandra Vaisman
How Does Cisplatin Kill Cells?
149
22
Daniel Fink
Stephen B. Howell
Part III: Clinical Antitumor Activity and Toxicology of Platinum Drugs
Clinical Experience with Cisplatin and Carboplatin
171
24
Martin S. Highley
A. Hilary Calvert
Clinical Experience: Platinum and Taxanes
195
36
Michelle Vaughan
Francisco Sapunar
Martin Gore
Clinical Experience: DACH-Based Platinum Drugs
231
20
Peter J. O'Dwyer
James P. Stevenson
Steven W. Johnson
Clinical Toxicology of Platinum-Based Cancer Chemotherapeutic Agents
251
26
Mark J. McKeage
Toxicology and Regulatory Aspects of Platinum Drugs
277
22
Diana L. Clark
Paul A. Andrews
D. D. Smith
Joseph J. DeGeorge
Robert L. Justice
Julie G. Beitz
Part IV: New Platinum Drugs of the Future
New Platinum Drugs: The Pathway to Oral Therapy
299
22
Lloyd R. Kelland
Polynuclear Charged Platinum Compounds as a New Class of Anticancer Agents: Toward a New Paradigm
321
18
Nicholas Farrell
Index
339