Series Introduction

Michael A. Kaliner

Preface

Contributors

I. Basic Aspects of Immunopharmacology

Biochemical and Pharmacological Basis of Receptor-Response Coupling and the Role of G-Proteins in the Action of Immune-Reacting Substances

Devendra K. Agrawal

Lymphokine-Induced Signal Transduction

Hallgeir Rui

Robert A. Kirken

Roy J. Duhe

O. M. Zack Howard

Gerald A. Evans

William L. Farrar

Fc&epsis;RI, &epsis;-BP, and Fc&epsis;RII: Structure and Involvement in Allergic Disease

Daniel H. Conrad

Cell Adhesion Molecules in Allergic Diseases

Devendra K. Agrawal

Arthur F. Kavanaugh

Immunological Basis for the Action of Immune-Reacting Substances

Mary E. Paul

Eric T. Sandberg

William T. Shearer

II. Inflammatory Cells in Allergic Diseases

Inflammatory Cell Differentiation and Maturation in Allergic Reactions

Judah A. Denburg

Brian F. Leber

Innervation of Inflammatory Cells

Andrzej M. Stanisz

Ruth M. Williams

Ron H. Stead

Mast Cell and Basophil Development and Function

John J. Costa

Stephen J. Galli

Lymphocytes

E. Maggi

S. Romagnani

Eosinophils

Julie B. Sedgwick

William W. Busse

Monocytes and Macrophages in Asthma

Jean Bousquet

Pascal Chanez

Bernard Arnoux

A. Maurizio Vignola

Marcelle Damon

Francois-Bernard Michel

Philippe Godard

Roles of Epithelial Cells and Fibroblasts in Allergic Diseases

John R. Spurzem

Debra J. Romberger

Stephen I. Rennard

III. Inflammatory Mediators in Allergic Diseases

Interleukin-1 and Tumor Necrosis Factor in Allergic Reactions

Edouard Vannier

Charles A. Dinarello

Neuropeptides and Their Receptors in Allergic Airway Diseases

David A. Ingram

Sunil P. Sreedharan

Edward J. Goetzl

Jeffrey L. Kishiyama

Histamine-Releasing Factors and Inhibitors: Relationship to the Chemokines

Rafeul Alam

J. Andrew Grant

IL-2, IL-4, IL-6, IL-10, IFN-γ, Their Receptors, Modulation of Their Actions, and Role in Allergic Responses

Toshio Tanaka

Yoshinori Katada

Hiroshi Ochi

Masaki Suemura

Tadamitsu Kishimoto

Interleukin-3, Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-5, and Their Receptors

Joshua A. Boyce

William F. Owen, Jr.

Nitric Oxide

Richard A. Robbins

Joseph H. Sisson

Leukotrienes: Their Receptors, Antagonists, and Synthesis Inhibitors

I. Caroline Crocker

Robert G. Townley

Platelet-Activating Factor and Its Antagonists in Allergic and Inflammatory Disorders

Matyas Koltai

David Hosford

Pierre G. Braquet

IV. Clinical Aspects of Immunopharmacology in Allergy

Adrenergic Receptors, Mechanisms, and the Late Allergic Reaction: Therapeutic Role of the New Long-Acting β-Agonists

Robert G. Townley

Phosphodiesterase IV Inhibitors as Potential Therapeutic Agents in Allergic Disease

Mark A. Giembycz

John E. Souness

Ion Channels and Airway Disease

Peter J. Barnes

Neuropeptides

James N. Baraniuk

Histamine Receptors and Antihistamines

Anoop J. Chauhan

Stephen T. Holgate

Pharmacological Modulation of Bronchial Challenges: Direct, Indirect, and Antigen

Russell J. Hopp

Robert G. Townley

Mast Cells and Antidegranulating Agents

Frederick L. Pearce

Corticosteroids: Mechanisms of Action and Treatment of Allergic Disease

John H. Toogood

Frederick A. White

Index