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Tables of Contents for New Therapeutic Agents for Thrombosis and Thrombolysis
Chapter/Section Title
Page #
Page Count
Series Introduction
iii
Samuel Z. Goldhaber
Preface
v
Contributors
xi
PART I. Overview
Overview of Hemostasis and Fibrinolysis
1
8
Joseph Loscalzo
Andrew I. Schafer
A Survey of Animal Models to Develop Novel Antithrombotic Agents
9
24
Walter P. Jeske
Omer Iqbal
Jawed Fareed
Brigitte Kaiser
Design Issues in Clinical Trials of Thrombolytic and Antithrombotic Agents
33
28
Dina S. Stolman
Marc K. Walton
Dwaine Rieves
Victor F. C. Raczkowski
Jay P. Siegel
PART II. New Heparins, Thrombin Inhibitors, and Other New Agents
Overview of New Anticoagulant Drugs
61
14
Jeffrey I. Weitz
Jack Hirsh
Low-Molecular-Weight Heparins in Acute Coronary Syndromes
75
16
David A. Morrow
Elliott M. Antman
Low-Molecular-Weight Heparin Use in Pregnancy
91
12
Wee Shian Chan
Jeffrey S. Ginsberg
Antithrombotic Therapy and Cancer
103
14
Gloria Petralia
Ajay K. Kakkar
Thrombosis Prophylaxis with Low-Molecular-Weight Heparin in Medical Patients
117
10
Walter Ageno
Alexander G. G. Turpie
Low-Molecular-Weight Heparins in Prevention and Treatment of Venous Thromboembolism
127
28
Richard M. Jay
William H. Geerts
Low-Molecular-Weight Heparin in the Pediatric Population
155
14
Manuela Albisetti
Maureen Andrew
New Indications for Low-Molecular-Weight Heparins
169
16
Omer Iqbal
Debra A. Hoppensteadt
Sarfraz Ahmad
Harry L. Messmore
Jawed Fareed
Clinical Use of Argatroban
185
16
Bruce E. Lewis
Jeanine M. Walenga
Hirudin for Acute Coronary Syndromes
201
16
John W. Eikelboom
Shamir R. Mehta
Salim Yusuf
Clinical Development of Bivalirudin
217
24
Robert A. Harrington
John M. Maraganore
Development of a Synthetic Heparin Pentasaccharide as an Antithrombotic Agent
241
24
Jeanine M. Walenga
Walter P. Jeske
Jawed Fareed
M. Michel Samama
Oral-Direct Thrombin Inhibitors
265
8
Mark A. Crowther
Orally Active Heparin
273
8
Graham F. Pineo
Russell D. Hull
Victor J. Marder
Tissue Factor Pathway Inhibitor: Potential Implications in the Treatment of Cardiovascular Disorders
281
20
Debra A. Hoppensteadt
Jawed Fareed
Brigitte Kaiser
Modulation of the Protein C Pathway as a Therapy for Thrombosis
301
22
Charles T. Esmon
Soluble Thrombomodulin
323
18
Mitsunobu Mohri
PART III. New Antiplatelet Agents
Overview: Antiplatelet Therapy
341
8
Robert P. Giugliano
Shaker A. Mousa
James T. Willerson
Abciximab
349
22
Deepak L. Bhatt
A. Michael Lincoff
Eptifibatide: A Potent Inhibitor of the Platelet Receptor Integrin, Glycoprotein IIb/IIIa
371
18
J. Conor O'Shea
James E. Tcheng
Robert A. Harrington
Robert M. Califf
Tirofiban: A Paradigm for ``Small-Molecule'' Glycoprotein IIb/IIIa Receptor Antagonists?
389
12
John K. French
Harvey D. White
Procoagulant Activities of Glycoprotein IIb/IIIa Receptor Blockers
401
12
Karlheinz Peter
Christoph Bode
Inhibitors of von Willebrand Factor Binding to Platelet Glycoprotein Ib
413
18
Joel L. Moake
James T. Willerson
Thienopyridines: Ticlopidine and Clopidogrel
431
20
Peter J. Sharis
Joseph Loscalzo
Oral Antiplatelet Therapies Beyond Aspirin and Thienopyridines
451
26
Shaker A. Mousa
Konstantinos Konstantopoulos
Robert Giugliano
PART IV. New Thrombolytic Agents
Overview of New Therapeutic Agents
477
2
Marc Verstraete
Clinical and Preclinical Profile of the Novel Recombinant Plasminogen Activator Reteplase
479
22
Michael Waller
Steven Mack
Ulrich Martin
Paul A. Minella
Tenectaplase: Biochemistry, Pharmacology, and Clinical Experience
501
12
Edward R. McCluskey
Canio J. Refino
Thomas F. Zioncheck
Richard Y. Chin
Lanoteplase
513
12
Robert P. Giugliano
Monteplase: Pharmacological and Clinical Experience
525
16
Chuichi Kawai
Suguru Suzuki
Pharmacological Action of and Clinical Experience with Pamiteplase, a Novel, Modified, Tissue-Type Plasminogen Activator
541
16
Tomihisa Kawasaki
Masanori Suzuki
Masao Katoh
Kohki Hayamizu
Recombinant, Glycosylated Prourokinase: Preclinical and Clinical Studies
557
26
Gregory A. Schulz
R. Bruce Credo
Debra A. Schuerr
Sandra E. Burke
Jack Henkin
Bruce A. Wallin
A Mutant Form of Prourokinase That Spares Hemostatic Fibrin
583
10
Victor Gurewich
Jian-ning Liu
Recombinant Staphylokinase for Thrombolytic Therapy
593
12
Peter Sinnaeve
H. Roger Lijnen
Desire Collen
Desmodus rotundus (Vampire Bat) Plasminogen Activator DSPAα1: A Superior Thrombolytic Created by Evolution
605
22
Wolf-Dieter Schleuning
Peter Donner
Alfimeprase
627
24
Christopher F. Toombs
In Vitro and In Vivo Models to Investigate Clot Lysis and Thrombolysis
651
18
Jean Marie Stassen
Thrombolysis and Ultrasound
669
18
Charles W. Francis
Valentina Suchkova
Epilogue: The Management of Thrombotic and Cardiovascular Disorders in the 21st Century
687
8
Jawed Fareed
Debra A. Hoppensteadt
Index
695