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Tables of Contents for Viral Infections of the Respiratory Tract
Chapter/Section Title
Page #
Page Count
Introduction
iii
Claude Lenfant
Preface
v
Contributors
vii
Introduction
1
4
Peter F. Wright
Part One VIRAL RESPIRATORY INFECTIONS IN DIFFERENT POPULATIONS
Acute Lower Respiratory Infections in Children
5
20
Floyd W. Denny, Jr.
Introduction
5
1
Classification of Acute Lower Respiratory Infections
6
1
Etiology of Acute Lower Respiratory Tract Infections
6
3
Role of Respiratory Viruses as Causes of Acute Lower Respiratory Infections in Children
9
4
Role of Various Risk Factors in the Occurrence of Acute Respiratory Infections
13
4
Role of Acute Respiratory Infections in Developing Countries
17
3
Summary and Conclusions
20
1
References
21
4
Viral Pneumonia in Adults
25
28
Stephen B. Greenberg
Introduction
25
1
Pathogenesis
26
1
Comparison of Viral Pneumonia in Children and Adults
27
1
Community-Acquired Viral Pneumonia
27
8
Diagnosis
35
1
Treatment and Prevention
35
3
Summary
38
1
References
38
15
Viral Pulmonary Infections in Older Persons
53
30
Ann R. Falsey
Introduction
53
1
Epidemiology
54
1
Influenza Virus
55
8
Respiratory Syncytial Virus
63
4
Parainfluenza Viruses
67
2
Rhinoviruses
69
2
Coronaviruses
71
1
Summary
72
1
References
73
10
Respiratory Viral Infections in Immunocompromised Patients
83
22
Raphael Dolin
Introduction
83
1
Cancer and Leukemia
84
1
Bone Marrow Transplantation
85
3
Solid Organ Transplantation
88
1
Human Immunodeficiency Virus Infection
89
2
Prevention
91
3
Treatment
94
1
Cytomegaloviral and Other Herpes Viral Infections
95
1
Summary
96
1
References
97
8
Part Two VIRUSES CAUSING RESPIRATORY INFECTIONS
Influenza A and B Viruses
105
56
John J. Treanor
Introduction
105
1
Viral Replication
106
3
Pathogenesis and Host Response
109
8
Epidemiology
117
6
Clinical Features
123
1
Complications
124
1
Diagnosis
125
1
Prevention and Therapy
126
11
Summary
137
1
References
138
23
Respiratory Syncytical Viruses
161
44
Edward E. Walsh
Barney S. Graham
Introduction and History
161
1
Viral Structure and Replication
162
2
Epidemiology
164
3
Nonadaptive Immune Response to Infection
167
1
Adaptive Immune Response to Infection
168
3
Disease Pathogenesis
171
4
Clinical Manifestations
175
3
Diagnosis
178
2
Therapy
180
2
Prevention
182
2
References
184
21
Parainfluenza Viruses
205
18
Peter F. Wright
Introduction
205
1
Similarity to Other Respiratory Viruses
206
1
Replicative Strategy
207
1
Pathogenesis of Parainfluenza Virus Infections
208
4
Epidemiology
212
1
Infections in Immunocompromised Hosts
213
1
Viral Diagnosis
214
1
Therapy
214
1
Prevention
215
1
Summary
216
1
References
216
7
Adenoviruses
223
30
Shaw-Guang Lee
William C. Gruber
Introduction
223
1
Classification and Morphology of Adenoviruses
224
2
Life Cycle and Replication
226
3
Unique Role of Specific Viral Proteins
229
3
Viral Pathogenesis
232
4
Epidemiology
236
1
Clinical Manifestations
237
3
Therapy: Antivirals and Passive Immunoglobulin Treatment
240
1
Prevention: Current and Potential Vaccine Strategies
240
2
Adenoviruses as Gene-Delivery Vectors
242
1
Summary
243
1
References
244
9
The Common Cold: Rhinoviruses and Coronaviruses
253
28
Mark R. Denison
Introduction
253
1
Rhinoviruses
254
11
Coronaviruses
265
8
Summary
273
1
References
273
8
Hantaviruses
281
26
Steven Q. Simpson
Howard Levy
Introduction
281
3
Viral Replication
284
2
Epidemiology
286
2
Clinical Manifestations
288
6
Pathology
294
1
Viral Pathogenesis
295
3
Therapy
298
2
Prevention
300
1
References
300
7
Part Three DIAGNOSIS
Laboratory Diagnosis of Infection with Respiratory Viruses
307
20
Marilyn A. Menegus
Introduction
307
1
Specimen Collection
308
1
Isolation of Viruses in Cell Culture
309
1
Antigen Detection
309
1
Immunofluorescent Antibody Staining
310
1
Enzyme-Linked Immunosorbent Assays
310
1
Polymerase Chain Reaction
311
1
Serology
312
1
Rhinoviruses
313
1
Respiratory Syncytial Virus
314
1
Influenza Viruses
314
2
Parainfluenza Viruses
316
1
Adenoviruses
317
1
Coronaviruses
318
1
Cytomegalovirus
319
2
Herpes Simplex
321
1
Conclusion
322
1
References
322
5
Part Four TREATMENT
Therapy of Viral Respiratory Infections
327
28
Arnold S. Monto
Introduction
327
1
Amantadine and Rimantadine
327
11
Ribavirin
338
7
Other Antivirals for Treatment of Infections of the Lung
345
1
Conclusions
345
1
References
346
9
Part Five PREVENTION
Prevention of Viral Respiratory Infections
355
20
Peter A. Gross
Influenza Virus Vaccines
355
10
Measles
365
2
Varicella-Zoster Virus
367
1
Respiratory Syncytial Virus
368
1
Parainfluenza Virus
369
1
Summary
369
1
References
370
5
Author Index
375
54
Subject Index
429