List of contributors

Foreword

Preface

Acknowledgements

Part 1: Basic science (physiology, molecular biology and pharmacology)

Physiology of ion channels

Stephen C. Cannon

Molecular biology of ion channels

Kylie A. Scoggan

Dennis E. Bulman

Pharmacology of ion channels

Jeffrey R. Balser

Alfred L. George, Jr

Part 2: Assessment of channel function (in vitro and in vivo)

Techniques for assessing ion channel functions; in vitro

Lawrence J. Hayward

Neurophysiological investigation of channelopathies in vivo

Kerry Mills

Part 3: Channel gene expression, distribution and its relationship to disease and normal development

Plasticity of ion channel gene expression as a substrate for channelopathies

Stephen G. Waxman

The role and consequences of ion channel distribution and dysfunction in pain

Sam Chong

John C. Hunter

The role of ion channel distribution, dysfunction and gene expression in demyelinating disease

Paul A. Felts

Part 4: Neuromuscular channel gene disorders (genetic)

Chloride and sodium channel myotonias

Karin Jurkatt-Rott

Frank Lehmann-Horn

Reinhardt Rudel

The periodic paraylses: hyperkalaemic and hypokalaemic paralysis

Rabi Tawil

Malignant hyperthermia

Terry D. Heiman-Patterson

Acetylcholine receptor channelopathies and other congenital myasthenic syndromes

Andrew G. Engel

Kinji Ohno

Steven M. Sine

Part 5: Neuromuscular channel disorders (acquired)

Myasthenia gravis and the Lambert Eaton syndrome

Angela Vincent

Autoimmune neuromyotonia

I. K. Hart

Part 6: Central nervous system channel disorders

Periodic and progressive ataxias

Robert W. Baloh

Epilepsies

Samuel F. Berkovic

Paroxysmal movement disorders as channelopathies

Kailash P. Bhatia

Enza Maria Valente

Hyperekplexia

Marina A. J. Tijssen

Peter Brown

Migraine: a multifactorial, neurovascular episodic channelopathy?

Peter J. Goadsby

Michael D. Ferrari

Part 7: Toxin-induced channel disorders

Ciguatera (fish poisoning)

Peter Fenner

Richard Lewis

Part 8: Potential channel disorders

Potential channelopathies: selected myotonic disorders - Schwartz Jampel syndrome (SJS), myotonic dystrophy (DM), myotonic dystrophy type-2 (DM-2), proximal myotonic myopathy (PROMM) and proximal myotonic dystrophy (PDM)

Richard Moxley

Andersen's syndrome

Valeria Sansone

Part 9: Conclusion

Conclusions

Michael Rose

Index