Preface

Acknowledgments

PART I Virology and Viral Disease

Introduction-The Impact of Viruses on Our View of Life

An Outline of Virus Replication and Viral Pathogenesis

Virus Disease in Populations and Individual Animals

Patterns of Some Viral Diseases of Humans

PART II Basic Properties of Viruses and Virus-Cell Interaction

Virus Structure and Classification

The Beginning and End of the Virus Replication Cycle

Host Immune Response to Viral Infection: The Nature of the Vertebrate Immune Response

Strategies to Protect Against and Combat Viral Infection

PART III Working with Virus

Visualization and Enumeration of Virus Particles

Replicating and Measuring Biological Activity of Viruses

Physical and Chemical Manipulation of the Structural Components of Viruses

Characterization of Viral Products Expressed in the Infected Cell

Viruses Use Cellular Processes to Express their Genetic Information

The Molecular Genetics of Viruses

PART IV Replication Patterns of Specific Viruses

Replication of Positive-Sense RNA Viruses

Replication Strategies of RNA Viruses Requiring RNA-Directed mRNA Transcription as the First Step in Viral Gene Expression

Replication Strategies of Small and Medium-Sized DNA Viruses

Replication of Some Nuclear-Replication Eukaryotic DNA Viruses with Large Genomes

Replication of Cytoplasmic DNA Viruses and ``Large'' Bacteriophages

Retroviruses: Converting RNA to DNA

Hepadnaviruses: Variations on the Retrovirus Theme

Viruses and the Future-Promises and Problems

Appendix-Resource Center

Technical Glossary

Index