PART I---TRANSPORT AND PHARMACOLOGY

Hormonal Inhibition of the Liver Plasma Membrane (Ca2+-Mg2+)ATPase Is Mediated by a Gs-like Protein

Sophie Lotersztajn

Catherine Pavoine

Ariane Mallat

Dominique Stengel

Paul Insel

Francoise Pecker

The High-Affinity (Ca2+-Mg2+) ATPase of Rat Liver Plasma Membrane Hydrolyzes Extracellular ATP

Sue-Hwa Lin

The Plasma Membrane Calcium Pump: Some Molecular Properties of the Purified Enzyme, with Emphasis on the Calmodulin-Binding Domain

Ernesto Carafoli

The Cardiac Sodium--Calcium Exchange System

John P. Reeves

Joo cheon

Molecular Properties of Dihydropyridine-Sensitive Calcium Channels

William A. Catterall

Michael J. Seagar

Masami Takahashi

Benson M. Curtis

Monoclonal Antibodies That Coimmunoprecipitate the 1,4-Dihydropyridine and Phenylalkylamine Receptors and Reveal the Ca2+ Channel Structure

Michel Fosset

Sylvie Vandaele

Jean-Pierre Galizzi

Jacques Barhanin

Michel Lazdunski

Criteria for Identification of α1 and α2 Subunits in a Purified Skeletal Muscle Calcium Channel Preparation

Pal L. Vaghy

Kunihisa Miwa

Kiyoshi Itagaki

Ferenc Guba Jr.

Edward McKenna

Arnold Schwartz

Phosphorylation of Dihydropyridine-Sensitive Calcium Channels from Cardiac and Skeletal Muscle

Christy L. Cooper

Cliff M. O'Callahan

M. Marlene Hosey

Phorbol Esters Stimulate Calcium Influx via Voltage-Dependent Channels in A7r5 Vascular Smooth-Muscle Cells

Wilson S. Colucci

Giovanni Sperti

Effects of cAMP-Dependent, Calmodulin-Dependent, and C-Type Protein Kinases on Platelet Calcium Transport

William L. Dean

Samuel Evans Adunyah

Molecular Structure of Canine Cardiac Phospholamban, the Regulatory Protein of Ca Pump ATPase of Sarcoplasmic Reticulum

Michihiko Tada

Masaaki Kadoma

Junichi Fujii

Ca2+ Transport by Liver and Plant Mitochondria: Aspects Linked to the Biological Role

Anibal E.Vercesi

Lucia Pereira-da-Silva

Ione S. Martins

Eva G. S. Carnieri

Celene F. Bernardes

Marcia M. Fagian

PART II---PHOSPHOINOSITIDE METABOLISM

Inositol Lipids and Intracellular Communication

Michael John Berridge

Receptor-Mediated Ca2+ Signaling: Role in Inositol-1,3,4,5-Tetrakisphosphate Generation

John R. Williamson

Roy A. Johanson

Carl A. Hansen

Jonathan R. Monck

Metabolism of Ins(1,3,4)P3 by Rat Liver Homogenates

C. J. Kirk

J. B. Parry

R. F. Irvine

R. H. Michell

S. B. Shears

Evidence for the Existence of the Inositol Tris/Tetrakisphosphate Pathway in Rat Heart

D. Renard

J. Poggioli

Mechanisms of Intracellular Calcium Movement Activated by Guanine Nucleotides and Inositol-1,4,5-Trisphosphate

Donald L. Gill

Julienne M. Mullaney

Tarun K. Ghosh

Sheau-Huei Chueh

Activation of the Inositol-1,4,5-Trisphosphate Signaling System by Acute Ethanol Treatment of Rat Hepatocytes

Andrew P. Thomas

Jan B. Hoek

Raphael Rubin

Emanuel Rubin

Regulation of Hepatic Glycogenolysis by Calcium-Mobilizing Hormones

Peter F Blackmore

Christopher J. Lynch

Stephen B. Bocckino

John H. Exton

Receptor Desensitization Is a Major Regulator of Hormone-Induced Ca2+ Mobilization in the Human Platelet

Michael F. Crouch

Eduardo G. Lapetina

Specific Receptors for Inositol-1,4,5-Trisphosphate in Endocrine Target Tissues

Gaetan Guillemette

Tamas Balla

Albert J. Baukal

Kevin J. Catt

Intracellular Calcium Transients Associated with Endothelium-Derived Relaxing Factor Release May Be Mediated by Inositol-1,4,5-Trisphosphate

Alex L. Loeb

Nicholas J. Izzo Jr.

Randolph M. Johnson

James C. Garrison

Michael J. Peach

Protein Kinase C in Rat Skeletal Muscle

Perry J. F. Cleland

Erik A. Richter

Stephen Rattigan

Eric Q. Colquhoun

Michael G. Clark

Activation of Phosphoinositide-Specific Phospholipase C by Ligands in the Presence of Guanine Nucleotides

John N. Fain

Michael A. Wallace

Richard J. H. Wojcikiewicz

Dejan Bojanic

Guanine Nucleotide-Dependent Release of Arachidonic Acid in Permeabilized Inflammatory Cells

Yukio Okano

Shigeru Nakashima

Toyohiko Tohmatsu

Kouji Yamada

Koh-ichi Nagata

Yoshinori Nozawa

PART III---CELL PROLIFERATION AND DIFFERENTIATION

Measurement of Free Intracellular Calcium (Cai) in Fibroblasts: Digital Image Analysis of Fura 2 Fluorescence

R. W. Tucker

K. Meade-Cobun

H. Loats

Growth Factors, Oncogenes, and Protein Kinase C

Ian G. Macara

George Gray

James Gaut

Anna Coco

Theresa Wingrove

Donna Faletto

Alan Wolfman

Insulin-like Growth Factor II Stimulates Calcium Influx in Competent Balb/c 3T3 Cells Primed with Epidermal Growth Factor

Ikuo Nishimoto

Etsuro Ogata

Itaru Kojima

Small-Cell Lung Cancer Bombesin Receptors Utilize Calcium as a Second Messenger

Terry W. Moody

Anne N. Murphy

Samira Mahmoud

Gary Fiskum

Extracellular Ca2+ and Cell Cycle Transitions: Effect of Protein Kinase C and InsP3

Alton L. Boynton

Jean Zwiller

Timothy D. Hill

Thomas Nilsson

Per Arkhammer

Per-Olof Berggren

Role and Properties of Ligand-Induced Calcium Fluxes in Lymphocytes

Sergio Grinstein

Stephen MacDougall

Roy K. Cheung

Erwin W. Gelfand

Modulation of c-fos and c-myc Expression by Effectors of Ion Movements

Anthony F. Cutry

Alan J. Kinniburgh

Kirk J. Leister

C. E. Wenner

Regulation of c-fos Expression by Voltage-Dependent Calcium Channels

James I. Morgan

Tom Curran

Calcium Pulses, Waves, and Gradients in Early Development

Lionel F. Jaffe

PART IV---REGULATION OF METABOLISM

Calcium Ions, Hormones, and Mammalian Oxidative Metabolism

James G. McCormack

Richard M. Denton

Regulation of Pyruvate Dehydrogenase in Isolated Cardiac Myocytes and Hepatocytes by Cytosolic Calcium

Richard G. Hansford

Rafael Moreno-Sanchez

James M. Staddon

Calcium as a Hormonal Messenger for Control of Mitochondrial Functions

Robert C. Haynes Jr.

Effect of Mitochondrial Ca2+ on Hepatic Aspartate Formation and Gluconeogenic Flux

Anna Sterniczuk

Stan Hreniuk

Russell Scaduto Jr.

Kathryn F. LaNoue

Regulatory Effects of a Thromboxane A2 Analogue on Hepatic Glycogenolysis and Vasoconstriction

Rory A. Fisher

Mark E. Steinhelper

Merle S. Olson

Metabolic Regulation of Ca2+ Handling in Permeabilized Insulinoma Cells

Barbara E. Corkey

Keith Tornheim

Jude T. Deeney

M. Clay Glennon

Janice C. Parker

Franz M. Matschinsky

Neil B. Ruderman

Marc Prentki

Calcium, Calmodulin, and Insulin Action in the Adipocyte

Jay M. McDonald

Joseph P. Laurino

Jerry Colca

Role of Calcium in the Regulation of Mammalian Lipoxygenases

Becky M. Vonakis

Jack Y. Vanderhoek

Phosphorylation and Modulation of Enzymatic Activity of Hepatic 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase by Multiple Kinases

Zafarul H. Beg

John A. Stonik

H. Bryan Brewer Jr.

Origin and Role of Calcium in Platelet Activation--Contraction--Secretion Coupling

Gundu H. R. Rao

Jonathan M. Gerrard

Isaac Cohen

Carl J. Witkop Jr.

James G. White

Calmodulin-like Ca2+-Binding Proteins of Smooth Muscle

Gwyneth de Vries

John R. McDonald

Michael P. Walsh

PART V---MECHANISMS OF CELL INJURY

Role of Ion Regulation in Cell Injury, Cell Death, and Carcinogenesis

Benjamin F. Trump

Irene K. Berezesky

Role of Calcium in Oxidative Cell Injury

Sten Orrenius

David J. McConkey

Pierluigi Nicotera

Cytosolic Free Calcium and Cell Injury in Hepatocytes

John J. LeMasters

Anna-Liisa Nieminen

Gregory J. Gores

Barnaby E. Wray

Brian Herman

Mechanisms of Anoxic Injury to Transport and Metabolism of Proximal Renal Tubules

Lazaro J. Mandel

William R. Jacobs

Rick Schnellmann

Maria Sgambati

Ann LeFurgey

Peter Ingram

X-Ray Microprobe Analysis of Subcellular Elemental Distribution in Normal and Injured Peripheral Nerve Axons

Richard M. Lopachin Jr.

Vicki R. Lopachin

Albert J. Saubermann

Prevention of Ischemic Brain Mitochondrial Injury by Lidoflazine

Robert E. Rosenthal

Gary Fiskum

Fozia Hamud

Role of Phosphoinositides in the Response of Mammalian Cells to Heat Shock

Stuart K. Calderwood

Mary Ann Stevenson

Cell Calcium in Malignant Hyperthermia: Skeletal Muscle Contraction and Ca2+ Regulation by Sarcoplasmic Reticulum

T. E. Nelson

Pathogenetic Roles of Intracellular Calcium and Magnesium in Membrane-Mediated Progressive Muscle Degeneration in Duchenne Muscular Dystrophy

Syamal K. Bhattacharya

Alice J. Crawford

Jay H. Thakar

Patti L. Johnson

PART VI---CARDIOVASCULAR PATHOPHYSIOLOGY

Characteristics and Functional Implications of Spontaneous Sarcoplasmic Reticulum-Generated Cytosolic Calcium Oscillations in Myocardial Tissue

Edward G. Lakatta

Maurizio C. Capogrossi

Harold A. Spurgeon

Michael D. Stern

Phospholipid--Calcium Relations at the Sarcolemma of the Cardiac Cell: Their Possible Role in Control of Contractility

G. A. Langer

Role of Membrane Dysfunction and Altered Calcium Homeostasis in the Pathogenesis of Irreversible Myocardial Injury

L. Maximilian Buja

James T. Willerson

Ischemic Alterations in Mitochondrial Calcium Transport Kinetics: An Indicator of Matrix Sulfhydryl Redox State

Jeanie B. McMillin

Daniel F. Pauly

Kiminori Kajiyama

Structural, Biochemical, and elemental Correlates of Injury in Cultured Cardiac Cells

Ann LeFurgey

Elizabeth Murphy

Bernhard Wagenknecht

Peter Ingram

Melvyn Lieberman

Interaction of Volatile Anesthetics with Calcium-Sensitive Sites in the Myocardium

T. J. J. Blanck

E. S. Casella

Cardiac Protection by Halothane Following Ischemia and Calcium Paradox

Zeljko J. Bosnjak

Sumio Hoka

Lawrence Turner

John P. Kampine

Defective Ca2+ Functions in Protein (47-kDa) Phosphorylation and in the Coupling to Physiological Responses in Platelets from Stroke-Prone Spontaneously Hypertensive Rats

Takako Tomita

Masahiko Ikeda

Keizou Umegaki

Nobuaki Takeshita

Kazuki Nakamura

Yasuhide Inoue

Effects of Elastin Peptides on Ion Fluxes

T. Fulop, Jr.

M. P. Jacob

G. Foris

Zs. Varga

L. Robert

Participants

Index