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Tables of Contents for Disorders of Synaptic Plasticity and Schizophrenia
Chapter/Section Title
Page #
Page Count
Contributors
xi
Introduction
xv
Loss of Spines and Neuropil
Liesl B. Jones
Introduction
1
1
Dendrites, Spines, and Normal Plasticity
2
1
Effects of Estrogen on Plasticity
3
1
Long-Term Potentiation and Learning
4
2
Alterations in Neuropil Components
6
1
Alzheimer's Disease
6
1
Human Immunodeficiency Virus Encephalitis
7
1
Huntington's Chorea
8
1
Schizophrenia
9
2
Possible Link between Calcium and Dendritic Alterations
11
1
Conclusion
12
7
References
13
6
Schizophrenia as a Disorder of Neuroplasticity
Robert E. McCullumsmith
Sarah M. Clinton
James H. Meador-Woodruff
Introduction
19
1
Clinical Features of Schizophrenia
20
1
Synaptic Plasticity and Schizophrenia
21
2
Substrates of Neuroplasticity
23
2
Glutamatergic Dysfunction in Schizophrenia
25
14
Conclusions
39
9
References
39
9
The Synaptic Pathology of Schizophrenia: Is Aberrant Neurodevelopment and Plasticity to Blame?
Sharon L. Eastwood
Introduction
48
1
Studies of Proteins Associated with Synaptic Plasticity in Schizophrenia
49
8
Can the Synaptic Pathology of Schizophrenia Be Related to Changes in the Expression of Genes Involved in Development and Plasticity?
57
7
Discussion and Future Directions
64
9
References
65
8
Neurochemical Basis for an Epigenetic Vision of Synaptic Organization
E. Costa
D. R. Grayson
M. Veldic
A. Guidotti
Introduction
73
1
Conceptual Background for the Definition of Phenotypes and Genotypes
74
1
Epigenetics and Evolution
75
1
Biochemical Processes Included in Epigenetic Phenomena
75
3
Epigenetics and Synaptic Plasticity
78
7
Epigenetics Today
85
1
The Epigenetic Concept in Psychiatry
86
1
Conclusions
87
6
References
87
6
Muscarinic Receptors in Schizophrenia: Is There a Role for Synaptic Plasticity?
Thomas J. Raedler
Introduction
93
1
Muscarinic Receptors
94
3
Schizophrenia
97
3
Synaptic Plasticity
100
12
References
103
9
Serotonin and Brain Development
Monsheel S. K. Sodhi
Elaine Sanders-Bush
Introduction
112
1
The Discovery of Serotonin and Classification of Serotonin Receptors
113
1
The Role of Serotonin in Developmental Plasticity
114
14
Manipulation of the Serotonergic System Alters Synaptic Plasticity
128
4
Does Dysfunction of Serotonergic Signaling Result in Impaired Brain Development?
132
17
Conclusions
149
26
References
150
25
Presynaptic Proteins and Schizophrenia
William G. Honer
Clint E. Young
Introduction
175
1
Presynaptic Proteins
176
3
Are All Presynaptic Proteins Affected Equally within a Single Brain Region?
179
6
Are Different Brain Regions Affected Equally for a Given Presynaptic Protein?
185
1
What Are the Relationships between mRNA and Protein Findings When Both Are Measured in the Same Study?
185
10
Microarray Studies
195
1
Summary
195
7
References
196
6
Mitogen-Activated Protein Kinase Signaling
Svetlana V. Kyosseva
Introduction
202
1
Mitogen-Activated Protein (MAP) Kinase Cascades
203
4
Role of MAP Kinases in the Central Nervous System
207
2
MAP Kinases of Schizophrenia
209
2
MAP Kinases in the Phencyclidine Rat Model of Schizophrenia
211
2
MAP Kinases and Psychiatric Disorders
213
1
Conclusions and Future Directions
214
8
References
214
8
Postsynaptic Density Scaffolding Proteins at Excitatory Synapse and Disorders of Synaptic Plasticity: Implications for Human Behavior Pathologies
Andrea De Bartolomeis
Germano Fiore
Introduction
222
1
Structural and Functional Organization of Postsynaptic Density (PSD) Proteins: An Overview
223
4
PSD-95/SAP90
227
5
Shank/ProSAP Proteins
232
2
SAP97
234
3
Homer Proteins
237
7
Conclusive Remarks
244
11
References
244
11
Prostaglandin-Mediated Signaling in Schizophrenia
S. Smesny
Introduction
255
1
Prostaglandin Hypothesis of Schizophrenia
256
1
Membrane Phospholipid Hypothesis of Schizophrenia
257
3
Niacin Tests in the Field of Schizophrenia
260
5
Summary
265
9
References
266
8
Mitochondria, Synaptic Plasticity, and Schizophrenia
Dorit Ben-Shachar
Daphna Laifenfeld
Introduction
274
1
Plasticity in Schizophrenia
275
4
Mitochondrial Dysfunction in Schizophrenia
279
3
Mitochondria and Neuroplasticity
282
5
Conclusion
287
11
References
288
10
Membrane Phospholipids and Cytokine Interaction in Schizophrenia
Jeffrey K. Yao
Daniel P. van Kammen
Abnormal Membrane Phospholipids
298
8
Disturbed Immune Function
306
3
Polyunsaturated Fatty Acids and Cytokines
309
1
Stress and Immune Response
310
1
Conclusion
311
17
References
314
14
Neurotensin, Schizophrenia, and Antipsychotic Drug Action
Becky Kinkead
Charles B. Nemeroff
Introduction
328
5
Preclinical Evidence Supporting the Role of Neurotensin in the Effects of Antipsychotic Drugs
333
5
Clinical Evidence Supporting the Role of Neurotensin Neurotransmission in the Pathophysiology of Schizophrenia
338
1
NTergic Compounds as Novel Antipsychotic Drugs
339
13
References
342
10
Schizophrenia, Vitamin D, and Brain Development
Alan Mackay-Sim
Francois Feron
Darryl Eyles
Thomas Burne
John McGrath
Introduction
352
1
Gene-Environment Interactions
353
2
Schizophrenia Susceptibility Genes
355
5
Gene-Environment Models of Schizophrenia
360
9
Conclusion
369
12
References
370
11
Possible Contributions of Myelin and Oligodendrocyte Dysfunction to Schizophrenia
Daniel G. Stewart
Kenneth L. Davis
Introduction
381
1
The Changing Role of Glia
382
1
Background on Oligodendroglia and Myelin
383
2
Disconnectivity in Schizophrenia
385
3
Imaging Evidence for White Matter Involvement in Schizophrenia
388
4
Demyelinating Diseases and the Symptoms of Schizophrenia
392
3
Age-Related Changes in Normal Aging
395
1
Expression of Myelin-Related Genes in Schizophrenia
396
6
Direct Examinations of Myelin and Oligodendroglia in Schizophrenia
402
2
Mechanistic Considerations
404
3
Summary and Future Directions
407
18
References
408
17
Brain-Derived Neurotrophic Factor and the Plasticity of the Mesolimbic Dopamine Pathway
Oliver Guillin
Nathalie Griffon
Jorge Diaz
Bernard Le Foll
Erwan Bezard
Christian Gross
Chris Lammers
Holger Stark
Patrick Carroll
Jean-Charles Schwartz
Pierre Sokoloff
Introduction
425
2
Brain-Derived Neurotrophic Factor (BDNF) Control D3 Receptor Expression during Development
427
1
BDNF Triggers Ectopic D3 Receptor Expression and Behavioral Sensitization in Denervated Rats
428
3
Normalization of Dopamine D3 Receptor Function Attenuates Dyskinesia Induced by Levodopa
431
3
BDNF and Dopamine D3 Receptor in Reactivity to Drug Cues
434
3
BDNF and Dopamine D3 Receptor in Stress, Depression, and Schizophrenia
437
1
Conclusions
438
7
References
439
6
S100B in Schizophrenic Psychosis
Matthias Rothermundt
Gerald Ponath
Volker Arolt
Background and Hypotheses
445
3
Origin and Molecular Structure of S100B
448
1
In Vitro/Cell Culture Experiments
449
5
Morphology Studies (Animal Experiments)
454
2
Serotonergic Regulation
456
1
Functional Studies
457
1
Clinical Studies in Schizophrenic Patients
458
3
Conclusions
461
10
References
463
8
Oct-6 Transcription Factor
Maria Ilia
Pou Domain Proteins
471
4
Oct-6
475
10
Conclusions
485
6
References
486
5
NMDA Receptor Function, Neuroplasticity, and the Pathophysiology of Schizophrenia
Joseph T. Coyle
Guochuan Tsai
Introduction
491
1
NMDA Receptors
492
2
Effects of Dissociative Anesthetics
494
1
Postmortem Studies of Glutamatergic Markers in Schizophrenia
495
2
Glutamate Receptor-Associated Genes
497
2
Preclinical Studies on NMDA Receptor Hypofunction
499
1
Clinical Trials of NMDAR Modulators in Schizophrenia
500
5
NMDA Receptor and Neuroplasticity
505
1
Conclusion
506
11
References
507
10
Index
517
14
Contents of Recent Volumes
531