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Tables of Contents for Genetic Mapping of Disease Genes
Chapter/Section Title
Page #
Page Count
Preface
vii
2
Acknowledgements
ix
5
Contributors
xiv
SECTION I: INTRODUCTION AND HISTORY
3
14
1. Introduction
3
6
J. H. Edwards
2. The early history of the statistical estimation of linkage
9
8
A. W. F. Edwards
SECTION II: LINKAGE IN DOMINANT, RECESSIVE AND OLIGOGENIC DISEASE
17
98
3. Oligogenic linkage and map integration
17
6
Newton E. Morton
Pietro Lio
4. Genetic mapping in complex disorders
23
8
Jurg Ott
5. Recessive disease and allelic association
31
28
J. H. Edwards
6. Mutation-selection-equilibria, genetic models and linkage analysis
59
14
Tiemo Grimm
Bertram Muller-Myhsok
7. Simple likelihood and probability calculations for linkage analysis
73
24
Cedric A. B. Smith
David A. Stephens
8. Tests for detecting linkage and linkage heterogeneity
97
18
Suzanne M. Leal
SECTION III: MODEL-FREE (NONPARAMETRIC) METHODS
115
92
9. Association and haplotype sharing due to identity by descent, with an application to genetic mapping
115
22
Martin A. van der Meulen
Gerard J. te Meerman
10. Conditional gene identity in affected individuals
137
10
Elizabeth A. Thompson
11. The affected sib pair method for linkage analysis
147
12
Michael Knapp
12. Association studies in genetic epidemiology
159
14
Max P. Baur
Michael Knapp
13. A note on the relative power of association studies and linkage analysis in the genetic analysis of disease
173
6
Bertram Muller-Myhsok
14. Use of association and linkage information for the study of multifactorial diseases
179
10
Francoise Clerget-Darpoux
15. SimIBD: a powerful robust nonparametric method for detecting linkage in general pedigrees
189
18
Sean Davis
Lynn R. Goldin
Daniel E. Weeks
SECTION IV: TOOLS
207
32
16. The Human Genome Mapping Project Resource Centre Computing Service
207
14
Frank R. Visser
17. The display of comparative mapping data using ACEDB
221
18
Jo Dicks
SECTION V: APPLICATIONS
239
36
18. From gene mapping to the identification of mutations: The example of the Hirschsprung's disease genes
239
8
Marcella Devoto
19. Retinal dystrophies: a molecular genetic approach
247
8
K. Evans
Shomi S. Bhattacharya
20. Problems in dealing with linkage heterogeneity in autosomal recessive forms of retinitis pigmentosa
255
20
Alan Wright
Peter W. Teague
Elspeth A. Bruford
Andrew D. Carothers
SECTION VI: FINAL COMMENTS
275
8
21. Final Comments
275
8
Elizabeth A. Thompson
List of acronyms
283
4
Index
287