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Tables of Contents for Advances in Clinical Chemistry
Chapter/Section Title
Page #
Page Count
Contributors
ix
 
Preface
xi
 
Lipoprotein Oxidation Products and Arteriosclerosis: Theory and Methods with Applicability to the Clinical Chemistry Laboratory
N. Abudu
James J. Miller
Stanley S. Levinson
Introduction
2
4
Radicals, Electrophiles, and Other Reactive Species
6
2
Oxidation Products of Lipids and Proteins and Measurement Methods
8
12
Detailed Procedures for Some Methods that Measure Oxidation Products in Plasma
20
3
Discussion
23
3
Conclusion
26
12
References
27
11
Measurement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMP) in Blood and Urine: Potential Clinical Applications
Stanley Zucker
Kaushik Doshi
Jian Cao
Introduction
38
1
Background
38
1
Biology and Chemistry of MMPs and TIMPs
39
3
Involvement of MMPs and TIMPs in Pathophysiology of Disease
42
3
Assays for Measurement of MMPs and TIMPs in Body Fluids
45
3
Blood Levels of MMPs and TIMPs in Physiologic and Disease States (Table 2)
48
22
Miscellaneous Diseases Associated with Increased Levels of MMPs and TIMPs
70
1
MMPs Identified in Urine of Patients with Cancer
71
2
Conclusions
73
14
References
74
13
Molecular Method to Quantitatively Detect Micrometastases and its Clinical Significance in Gastrointestinal Malignancies
H. Nakanishi
Y. Kodera
M. Tatematsu
Introduction
87
2
Methodology
89
3
Quantitative Detection of Micrometastases and its Prognostic Significance
92
9
General Considerations and Future Directions
101
11
References
103
9
Zymographic Evaluation of Plasminogen Activators and Plasminogen Activator Inhibitors
Melinda L. Ramsby
Introduction
112
1
Monitoring the PA/PAI System
113
3
Materials and Methods for Overlay Zymography
116
3
Results
119
5
Conclusion
124
11
References
124
11
Estrogen Metabolites, Conjugates, and DNA Adducts: Possible Biomarkers for Risk of Breast, Prostate, and Other Human Cancers
Eleanor G. Rogan
Ercole L. Cavalieri
Introduction
135
4
Analysis of Estrogens and their Metabolites, Conjugates, and Depurinating DNA Adducts
139
5
Biomarkers for Increased Risk of Developing Estrogen-Initiated Cancer
144
8
References
146
6
Organophosphates/Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, and Treatment
Jiri Bajgar
Introduction
152
1
Chemistry, Mechanism of Action, and Symptoms
153
14
Cholinesterase Inhibitors and Other Factors Influencing the Activity
167
9
Diagnosis
176
10
Prophylaxis
186
4
Treatment
190
6
Future Trends
196
1
Summary
197
20
References
198
19
The Potential of Protein-Detecting Microarrays for Clinical Diagnostics
Alexandra H. Smith
Jennifer M. Vrtis
Thomas Kodadek
Introduction
217
1
Diagnostic Signatures
218
7
Protein-Detecting Microarrays
225
9
Conclusions
234
6
References
234
6
Clinical Laboratory Implications of Single Living Cell mRNA Analysis
Toshiya Osada
Hironori Uehara
Hyonchol Kim
Atsushi Ikai
Introduction
240
1
AFM
240
2
Manipulations of Biological Material with AFM
242
3
mRNA Extraction from Living Cells
245
7
Modification of AFM Tips
252
7
References
255
4
Letter to the Editor
259
2
Index
261