Product Description: Provides an engaging account of how genetic abnormalities, neurobiology and neuropsychology work in concert to manifest cognitive-behavioral dysfunction. The authors have woven the various molecular genetic, genomic, neurophysiological and neurobehavioral threads together into a cohesive fabric of human genes, brain, and behavior...read more

Product Description: The introduction of high-performance liquid chromatography (HPLC) to the analysis of peptides and proteins some 25 years ago revolutionized the biological sciences by enabling the rapid and sensitive analysis of peptide and protein structure through the exquisite speed, sensitivity, and resolution that can be easily obtained...read more

Product Description: Jump into the HPLC adventure! Three decades on from publication of the 1st German edition of Veronika Meyer's book on HPLC, this classic text remains one of the few titles available on general HPLC aimed at practitioners. New sections on the following topics have been included in this fifth edition: Comparison of HPLC with capillary electrophoresis How to obtain peak capacity van Deemter curves and other coherences Hydrophilic interaction chromatography Method transfer Comprehensive two-dimensional HPLC Fast separations at 1000 bar HPLC with superheated water In addition, two chapters on the instrument test and troubleshooting in the appendix have been updated and expanded by Bruno E...read more

Veronika Meyer’s book on HPLC is a classic text and remains one of the few titles available on general HPLC. Following on from the success of the previous three editions, this new, fourth edition continues to provide users of HPLC in industry, government, and service laboratories, as well as postgraduate students, with a unified approach to HPLC and an equal treatment of the theory and practice of this important technique. The contents of this edition have been revised, expanded and updated. Where available, old literature references have been replaced by recent ones. New sections on the following topics have been included:  Shelf-live of mobile phases The mixing cross Phase systems in ion chromatography Measurement uncertainty

Product Description: Traditionally mycotoxins are mainly determined by immunoassay screening methods or by single compound chromatographic analytical methods, based on immunoaffinity column cleanup followed by a separation step using thin layer chromatography (TLC), gas chromatography (GC) or liquid chromatography (LC), which were coupled to conventional detectors such as electron capture detection (ECD), fluorescence or UV-visible detection...read more

Product Description: Chromatography has many roles in forensic science, ranging from toxicology to environmental analysis. In particular, high-performance liquid chromatography (HPLC) is a primary method of analysis in many types of laboratories. Maintaining a balance between practical solutions and the theoretical considerations involved in HPLC analysis, Forensic Applications of High Performance Liquid Chromatography uses real-life examples likely to be found within a forensic science laboratory to explain HPLC from a forensic perspective...read more

For "baby" analysis with single variable only. Appropriate for one term courses in analysis and advanced calculus. Text starts with a little logic and how to construct a proof. Revision features: material on the topology of the reals has been expanded and divided into two sections. Two optional sections on metric spaces and continuity in metric spaces have been added.

Our path of economic development has generated a growing list of environmental problems including the disposal of nuclear waste, exhaustion of natural resources, loss of biodiversity, climate change, and polluted land, air, and water. All these environmental problems raise the crucial challenge of determining what we should and should not do for future generations. It is also central to other policy debates, including, for example, the appropriate level of public debt, investment in public infrastructure, investment in education, and the level of funding for pension benefits and for research and development. Today, the judge, the citizen, the politician, and the entrepreneur are concerned with the sustainability of our development. The objective of Pricing the Planet's Future is to provide a simple framework to organize the debate on what we should do for the future. A key element of analysis by economists is the discount rate--the minimum rate of return required from an investment project to make it desirable to implement. Christian Gollier outlines the basic theory of the discount rate and the various arguments that favor using a smaller discount rate for more distant cash flows. With principles that can be applied to many policy areas, Pricing the Planet's Future offers an ideal framework for dynamic problems and decision making.

Product Description: Stability-Indicating HPLC Methods for Drug Analysis compiles summaries of stability-indicating HPLC analytical methods that have appeared in the published literature. A first stop for pharmaceutical scientists, analytical chemists, and librarians in the quest for information about the stability of drugs...read more

Product Description: This is one of the first books to focus on the dynamic aspect of proteomes. The book introduces proteomics to the newcomer, reviews the theoretical aspects of proteomics and its state-of-the art technologies, along with a number of biological applications using "classical" proteomic technology...read more

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.

HPLC: A Practical User's Guide is essential for chromatographers needing a proven training manual for setting up and running an HPLC system, for optimizing and cleaning columns and separations, and for obtaining separations and maximizing information from their system. Relying upon 15 years of laboratory and field troubleshooting experience, the author explains the basic techniques and shows how to use them to optimize separations. Proven methods are provided for starting up and maintaining HPLC systems, cleaning and troubleshooting column to the system problems, and systematic column treatment and methods development, both manual and automated. Coverage includes preparative HPLC, Diode Array, UV detectors, recent advances in HPLC/mass spectrometry, and a discussion of hardware configurations and interfacing to computers and data acquisition devices. A guide to separations, a glossary of terms, and a programmed self-learning guide are also included.

Product Description: The different LC-MS techniques available today were developed to suit specific analytical needs and the application range covered by each one is wide, but still limited. GC amenable compounds can be all analyzed with a single GC-MS system whereas HPLC applications call for specific LC-MS instrumental arrangements...read more

Product Description: This latest volume in the series entitled Liquid Chromatography of Natural Pigments and Synthetic Dyes presents an overview of the latest developments in the field while critically evaluating this method of analysis and providing comparisons of the various liquid chromatographic separation techniques that are currently available...read more

The revised edition of this book provides an up-to-date overview of the role of transcription factors in gene regulation, focusing primarily on the role of individual specific factors in biological processes such as the steroid response, and cell-type determination. Transcription factors play a fundamental role in turning genes on and off in particular cell types, during embryonic development, or in response to specific skills and are of interest to scientists from a variety of disciplines. However, the bewildering array of these proteins and the different ways in which they act can prove daunting to scientists and newcomers to molecular genetics. This book aims to provide the reader with a clear understanding of this field. It should be useful reading for those who seriously wish to understand the impact of molecular biology on medicine, whatever their speciality.