Product Description: In 2003 the Human Genome Project announced that it had achieved a stunning scientific breakthrough: the full map of the human genome, and with it our first complete picture of the basic building block of human life. Since then, boasts about the benefits—and warnings of the dangers—of genomics have remained front-page news...read more

Product Description: Since the advent of the Human Genome Project, an increasing number of disease-causing genes have been discovered and, in some cases, genetic tests developed. However, this is only the first step. The second, much larger phase is the analysis of the total sequence...read more

The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and hypotheses on the key aspects of the evolution of life on earth in light of comparative genomics and systems biology. The author presents many specific examples from systems and comparative genomic analysis to begin to build a new, much more detailed, complex, and realistic picture of evolution. The book examines a broad range of topics in evolutionary biology including  the inadequacy of natural selection and adaptation as the only or even the main mode of evolution; the key role of horizontal gene transfer in evolution and the consequent overhaul of the Tree of Life concept;  the central, underappreciated evolutionary importance of viruses; the origin of eukaryotes as a result of endosymbiosis; the concomitant origin of cells and viruses on the primordial earth; universal dependences between genomic and molecular-phenomic variables; and the evolving landscape of constraints that shape the evolution of genomes and molecular phenomes.   "Koonin's account of viral and pre-eukaryotic evolution is undoubtedly up-to-date. His "mega views" of evolution (given what was said above) and his cosmological musings, on the other hand, are interesting reading." Summing Up: Recommended Reprinted with permission from CHOICE, copyright by the American Library Association.  

Product Description: A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle...read more

Product Description: Here is a manual for an environmental scientist who wishes to embrace genomics to answer environmental questions. The volume covers: gene expression profiling, whole genome and chromosome mutation detection, and methods to assay genome diversity and polymorphisms within a particular environment...read more

Product Description: This is the first book to give a full overview on genome integrity in different species. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. Written by an international panel of experts, the book addresses the connection between genome integrity and human disease...read more

Product Description: With examples replete from Africa and especially South Africa, Wilmot James draws on established biological science to tell some compelling stories about the genome, why we have different skin colors, how blood tells a special story of human history, why the brain likes music, how smell works, the nature of rock art, why kids love bugs and the teaching of evolution...read more

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Presents an explanatory framework for how the architectural diversity of eukarotic genomes and genes came to arise. Presented in non-technical fashion, this work is suitable for use in an advanced Genetics course and as a professional reference.

Product Description: Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences...read more

Product Description: The publication of the first draft of the human genome five years ago marked the start of a new era of vertebrate comparative genomics. Genome draft sequences for chimpanzee, mouse, rat, dog, chicken as well as for several fish species are now available for the reconstruction of the evolutionary history of vertebrate genomes over the last 450 million years...read more

Covering molecular genetics from the basics through to genome expression and molecular phylogenetics, this book is useful for undergraduates throughout their studies in molecular genetics. It puts genomes, rather than genes, at the centre of molecular genetics teaching.

Product Description: George Beadle was a towering scientific figure whose work from the 1930s to 1960 marked the transition from classical genetics to the molecular era. Among other distinctions, he made the pivotal, Nobel Prize Swinning discovery with Edward Tatum that the role of genes is to specify proteins...read more

Product Description: Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease...read more

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Draws on the latest genome research to identify the relationships between genes and living cells, arguing that key facts about biological life can only be discovered through an understanding of the relationships between the molecules that make up living cells from generation to generation. (view table of contents)