Product Description: Recent advances in the field of recombinant antibodies have permitted the manipulation of genes encoding specific antibodies, thus allowing their ectopic expression in a wide variety of non-lymphoid cells. This volume describes how the ectopic expression of antibodies, as secreted or as intracellularly retargeted molecules, can be exploited to block biological functions or to confer new phenotypic traits (e...read more

Product Description: In the rapidly developing area of neuroimmunology, primary at­ tention has been given thus far to the bidirectional exchange of information between the immune system and the neuroendocrine system. Several recent texts on this subject are based alm ost exclu­ sively on experimental and clinical data obtained in mammalian species...read more

The initial impetus to create a work combining aspects of cel lular immunology with their clinical applications grew from the ed itors' discussions of the area's needs with many of the leaders in the field over a period of time. From the nucleus of ideas that emerged, we have here attempted to create a unified and inte grated coverage of the rapidly growing field of cellular immunology research and to trace out-from what seems at times a genuine plethora of important new findings-the many and often impor tant clinical implications. Because of this approach, the chapters of Clinical Cellular Im munology attempt to be more than critical reviews of research and clinical data, going beyond analysis to synthesize working hypotheses about the functional meaning of cellular immunological phenomena and their likely clinical significance. To accomplish this undertaking, the text begins first with a consid eration of the molecular aspects of antigen recognition (Luderer and Harvey) and of the ensuing regulatory program initiation (Fathman). Then, the functional subsets oflymphocytes as they in teract to produce and control the developing immune response are explored in detail (Sigel et a1.), followed by a unique analytical dis section of the action of immunosuppressive agents on the sundry inductive and regulatory immunologic pathways (Sigel et al.). A majority of the data and conclusions drawn by the authors in the previous chapters arise from work on murine systems, al though wherever appropriate, human data has been introduced.

Product Description: This collection of reviews contains contributions by internationally recognized immunologists and molecular and cellular neurobiologists. Uniquely, it puts side by side cellular communication devices and signaling mechanisms in the immune and nervous systems and discusses mechanisms of interaction between the two systems, the significance of which has only recently been fully appreciated...read more

Product Description: Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology...read more

Product Description: Toll-Like Receptors are invaluable in the fight against infection and can lead to the pathogenesis of disease. This reference details procedures on how to identify, characterize and measure Toll-like receptor expression and downstream signaling.

Product Description: Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc...read more

Product Description: This clear, accessible treatment of mathematics features a building-block approach toward problem solving, realistic and diverse applications, and chapter organizer to help users focus their study and become effective and confident problem solvers...read more (view table of contents, read Amazon.com's description)

Product Description: Providing a thorough overview of the fundamental elements of the human allergic immune response, this up-to-date reference focuses on the unique molecular and cellular features of the IgE-mediated immune response-relating these features to current knowledge of the immune response to protein antigens...read more

Product Description: Within the last 10 years, the immune system of ruminants, especially T cells and their interactions with other cells, has been an important topic of study for veterinary immunologists and an area of interest for medical and fundamental immunologists...read more

Product Description: This textbook provides a thorough introduction to modern cellular and molecular immunology for undergraduate science students and for clinicians. Johnathan Austyn and Kathryn Wood have adopted the novel approach of arranging the book around a map of the immune system, with each chapter focusing on a different aspect...read more

Product Description: Reviewing the role played by the thymus in the regulation of cellular immunity, this text discusses basic anatomy and physiology of the mammalian thymus, including reviews of thymic embryology, gross anatomy, microanatomy, microenvironment, and cytokines and hormones produced by the thymus...read more

Product Description: Presents a comprehensive review of cell-mediated immunity to viral infection, highlighting aspects relevant to HIV research. Opening chapters discuss antigen processing and presentation, and lymphokine function. Subsequent chapters consider immune responses to individual viruses including: HIV, vis...read more

Product Description: This book provides an analysis of the current subdisciplines comprising the study of humoral immune response. The first chapter presents a detailed discussion regarding the experimental and conceptual studies conducted prior to the mid-1970s that have served as a valuable research framework for investigators interested in the process by which B cells are activated following their exposure to antigens...read more

Product Description: Knowledge regarding avian cellular immunity has expanded rapidly within the last few years and new information continues to accumulate. It is now a well-established fact that cell-mediated immunity plays a major role in the defense against neoplastic and non-neoplastic diseases in chickens...read more